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The effect of varying molar ratios of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss.

Author: PakC Y, PoindexterJ, RumlL A, WuermserL A

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Three formulations of potassium-magnesium citrate were compared for their effectiveness in correcting thiazide-induced hypokalemia and magnesium loss. All three formulations were effective in correcting hypokalemia, but K3MgHCit2 and K4MgCit2 were more effective in increasing serum magnesium and urinary pH and citrate.
Paper Details　
Original Abstract of the Article :
This study was conducted to compare the value of an older formulation of potassium-magnesium citrate (K4MgCit2) with newer formulations (K3MgHCit2 and K5MgCit2Cl) with respect to the correction of thiazide-induced hypokalemia and magnesium loss, alkalinizing effect, and citraturic action. Sixty-two ...See full text at original site
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引用元：
https://doi.org/10.1177/009127009803801108

データ提供：米国国立医学図書館（NLM）

Navigating the Complexities of Thiazide-Induced Hypokalemia

The management of electrolyte imbalances, particularly hypokalemia, is a critical aspect of medical care, especially when dealing with medications that can affect electrolyte levels. This research investigates the efficacy of various potassium-magnesium citrate formulations in addressing thiazide-induced hypokalemia and magnesium loss. The authors meticulously compare different formulations, analyzing their impact on serum electrolyte levels and urinary excretion patterns. Their findings provide valuable insights into the optimal strategies for managing thiazide-related electrolyte imbalances.

A Comparative Analysis of Potassium-Magnesium Citrate Formulations

The research offers a comparative analysis of different potassium-magnesium citrate formulations, providing valuable insights into their efficacy in addressing thiazide-induced hypokalemia and magnesium loss. The authors demonstrate that all three formulations were effective in correcting hypokalemia, but variations in their efficacy with regard to magnesium levels and urinary excretion patterns suggest the importance of careful selection based on individual patient needs.

Tailored Approaches to Electrolyte Management

This research underscores the importance of tailoring treatment strategies to address individual patient needs, particularly when managing electrolyte imbalances. The authors' comparative analysis highlights the subtle but significant differences in the efficacy of various potassium-magnesium citrate formulations, emphasizing the need for a personalized approach to electrolyte management.

Dr.Camel's Conclusion

Navigating the desert of electrolyte imbalances requires a careful and measured approach. This research sheds light on the intricacies of thiazide-induced hypokalemia and magnesium loss, providing valuable insights into the effectiveness of various potassium-magnesium citrate formulations. The study encourages a personalized approach to electrolyte management, ensuring that patients receive the most effective and appropriate care.

Date :
  1. Date Completed 1999-01-29
  2. Date Revised 2019-08-26
Further Info :

Pubmed ID

9824785

DOI: Digital Object Identifier

10.1177/009127009803801108

SNS
PICO Info
in preparation
Languages

English

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