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[Zidovudine plus didanosine in HIV infected asymptomatic patients previously treated with zidovudine].

Author: GuarnerJ, López-MartínezC, Magis-RodríguezC, Uribe-ZúñigaP, del Río-ChiribogaC

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

Adding didanosine (ddl) to patients already taking AZT for at least six months resulted in a significant increase in CD4+ T cell counts at three months. However, this increase gradually declined to below baseline levels at 18 months. While adverse effects were frequent, they did not lead to discontinuation of therapy in most patients.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To evaluate if the combination of AZT/ddl offered any advantages in surrogate markers among HIV infected asymptomatic patients previously treated with AZT for at least six months. METHODS: We used a prospective cohort of 269 asymptomatic HIV patients with CD4+ cell counts between 200 and...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9830323

データ提供：米国国立医学図書館（NLM）

Zidovudine and Didanosine: A Combined Approach for HIV Treatment

This study investigates the [efficacy] of combining [zidovudine] and [didanosine] in the treatment of [asymptomatic HIV patients] who had previously received [zidovudine monotherapy]. The researchers found that adding [didanosine] to [zidovudine] led to a [transient increase] in [CD4+ cell counts] but eventually declined to [baseline levels]. While the [combination therapy] showed some benefits, it also resulted in [frequent adverse effects].

A Shifting Landscape: Combining Zidovudine and Didanosine for HIV Treatment

The study explores the potential of combining two HIV medications, zidovudine and didanosine, in treating asymptomatic patients previously treated with zidovudine alone. The findings suggest that while the combination can lead to temporary improvements in CD4+ cell counts, it also poses potential risks due to adverse effects. This research highlights the need for careful evaluation and personalized treatment approaches for HIV patients.

Navigating the Desert of HIV Treatment

The desert of HIV treatment is a landscape marked by constant change and challenges. This study provides valuable insights into the potential benefits and risks of combining specific medications, zidovudine and didanosine, for treating asymptomatic HIV patients. It reminds us that finding the right path through this desert requires a careful balance of hope and vigilance.

Dr.Camel's Conclusion

This research explores the potential benefits and challenges of combining zidovudine and didanosine for treating asymptomatic HIV patients. It underscores the need for careful evaluation and personalized treatment approaches in the complex desert of HIV treatment.
Date :
  1. Date Completed 1998-12-08
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9830323

DOI: Digital Object Identifier

9830323

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Languages

Spanish

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