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Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and LogMAR acuity.

Author: CrabbD P, EdgarD F, GuttridgeN M, LawrensonJ G, O'BrienC J, RudnickaA R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Dipivefrin caused mydriasis but did not affect visual fields or acuity. Pilocarpine had negative effects on visual fields and acuity.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A study was carried out to ascertain, in ophthalmologically normal subjects, the short-term effects of dipivefrin hydrochloride 0.1% on visual performance and make comparisons with pilocarpine. METHODS: Twelve normal volunteers aged 20-26 years attended on three occasions. One eye, rand...See full text at original site
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引用元：
https://doi.org/10.1007/s004170050206

データ提供：米国国立医学図書館（NLM）

Dipivefrin and Pilocarpine: Impact on Pupil Diameter, Visual Field, and Acuity

Glaucoma treatment often involves medications that influence pupil size and visual function. This study investigates the effects of two commonly used glaucoma medications, dipivefrin and pilocarpine, on pupil diameter, visual field, and acuity in healthy volunteers. The researchers sought to understand how these medications affect visual performance, providing valuable insights for glaucoma management.

Dipivefrin: A Visual Field-Preserving Option

The study found that dipivefrin caused mydriasis (pupil dilation) but did not significantly affect the central visual field or high- and low-contrast acuity. This suggests that dipivefrin could be a valuable treatment option for glaucoma patients, potentially preserving visual field function while effectively lowering intraocular pressure. In contrast, pilocarpine, another glaucoma medication, caused miosis (pupil constriction) and significantly worsened visual field performance, emphasizing the importance of considering the potential impact of medication on visual function.

Tailoring Glaucoma Treatment to Individual Needs

This study underscores the importance of individualizing glaucoma treatment based on the patient's specific needs and visual function. Understanding the impact of different medications on pupil size, visual field, and acuity can help clinicians select the most appropriate treatment options for each patient, maximizing therapeutic efficacy and minimizing potential adverse effects.

Dr.Camel's Conclusion

Just like different desert plants adapt to varying water levels, different glaucoma medications can impact visual function in distinct ways. This research highlights the importance of choosing the right medication for each patient, ensuring optimal treatment while preserving visual function.

Date :
  1. Date Completed 1999-03-25
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

9987628

DOI: Digital Object Identifier

10.1007/s004170050206

Related Literature

Article Analysis
・Effects of dipivefrin ophthalmic
SNS
PICO Info
in preparation
Languages

English

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