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Randomized controlled comparison of nitroimidazoles for the eradication of Helicobacter pylori and relief of ulcer-associated and non-ulcer dyspepsia.

Author: GoddardA F, LawesS, LoganR P, SpillerR C

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Treatment with omeprazole, clarithromycin, and metronidazole (OCM) is as effective as the more expensive tinidazole regimen (OCT) at eradicating Helicobacter pylori. H. pylori eradication results in long-term relief of dyspeptic symptoms and reduced antisecretory consumption only in patients with duodenal ulcer, and not in those with non-ulcer dyspepsia.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A combination of omeprazole, clarithromycin and either metronidazole or tinidazole is commonly used for Helicobacter pylori eradication. Metronidazole is considerably cheaper than tinidazole but the two have not previously been compared in a randomized trial. METHODS: One hundred and tw...See full text at original site
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引用元：
https://doi.org/10.1046/j.1365-2036.1999.00513.x

データ提供：米国国立医学図書館（NLM）

Eradicating Helicobacter pylori: A Head-to-Head Comparison of Nitroimidazoles

This study compares the efficacy of two nitroimidazole antibiotics, metronidazole and tinidazole, in eradicating Helicobacter pylori infection and relieving dyspepsia. The researchers conducted a randomized controlled trial to evaluate the effectiveness of these antibiotics when used in combination with omeprazole and clarithromycin. The study aims to determine the optimal treatment strategy for H. pylori eradication and assess the impact on dyspeptic symptoms.

Metronidazole and Tinidazole: A Tale of Two Nitroimidazoles

The study reveals that both metronidazole and tinidazole, when used in combination with omeprazole and clarithromycin, are highly effective in eradicating H. pylori infection. The researchers found similar eradication rates for both regimens, with both successfully achieving eradication in approximately 95% of patients. These findings suggest that both antibiotics are equally effective in treating H. pylori infection, offering clinicians flexibility in selecting the most appropriate option based on patient factors.

Addressing Dyspepsia: The Importance of H. pylori Eradication

The study underscores the importance of H. pylori eradication for long-term relief of dyspeptic symptoms. The researchers observed significant symptom improvement and reduced antisecretory drug use only in patients with peptic ulcers. This finding highlights the crucial role of H. pylori eradication in managing dyspepsia and emphasizes the importance of addressing this infection for optimal patient outcomes.

Dr.Camel's Conclusion

Just like a desert oasis offering a vital source of water, H. pylori eradication can bring relief to those suffering from dyspepsia. This study provides valuable insights into the effectiveness of different treatment strategies, empowering clinicians to choose the best approach for their patients.

Date :
  1. Date Completed 1999-06-10
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

10233187

DOI: Digital Object Identifier

10.1046/j.1365-2036.1999.00513.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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