Side Effects of omeprazole clarithromycin: A Synthesis of Findings from 29 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of omeprazole clarithromycin: A Synthesis of Findings from 29 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Main Research Findings

Multiple studies have shown that treatment with omeprazole, clarithromycin, and amoxicillin for one week is effective in eradicating Helicobacter pylori (HP) in patients with peptic ulcers and symptomatic chronic gastritis. 27 . This treatment regimen has been shown to be more effective and tolerable than traditional bismuth-based triple therapy. 17 . Furthermore, one-week low-dose triple therapy can significantly improve eradication rates by reducing side effects and improving patient compliance. 22 . However, in patients with metronidazole-resistant H. pylori, quadruple therapy may be more effective. 3 .

Reasons for Side Effects

The side effects of omeprazole, clarithromycin, and amoxicillin are due to the effects of these drugs on the gastrointestinal system. Omeprazole inhibits the secretion of gastric acid, increasing the pH of the stomach. This can promote the growth of bacteria in the stomach, increasing the risk of infection. Clarithromycin and amoxicillin are antibiotics that can disrupt the normal bacterial flora in the intestines. This can lead to side effects such as indigestion, diarrhea, and abdominal pain.

Common Side Effects

Gastrointestinal

Taking omeprazole, clarithromycin, and amoxicillin can cause gastrointestinal side effects. The most common side effects are diarrhea, abdominal pain, nausea, vomiting, constipation, bloating, indigestion, and mouth sores. These side effects are usually mild and gradually improve as treatment continues. 29 .

Nervous System

Taking omeprazole, clarithromycin, and amoxicillin can cause nervous system side effects such as headaches, dizziness, drowsiness, and taste disturbances. 29 . These side effects are usually mild and gradually improve as treatment continues.

Skin

Taking omeprazole, clarithromycin, and amoxicillin can cause skin side effects such as rash, itching, and hives. 29 . These side effects are usually mild and gradually improve as treatment continues. If severe, consult a doctor.

Other Side Effects

Taking omeprazole, clarithromycin, and amoxicillin can cause other side effects. These include fever, fatigue, loss of appetite, liver function abnormalities, kidney function abnormalities, and decreased blood cell counts. These side effects are usually mild and gradually improve as treatment continues. If severe, consult a doctor.

Countermeasures for Side Effects

Gastrointestinal

To reduce gastrointestinal side effects, it is important to make dietary and lifestyle changes. Avoid fatty foods and spicy foods in particular. It is also important to drink plenty of fluids. If diarrhea is severe, consult a doctor and get a prescription for appropriate medication.

Nervous System

To reduce nervous system side effects, get enough rest. Also, avoid driving or operating hazardous machinery. If drowsiness or dizziness is severe, consult a doctor.

Skin

To reduce skin side effects, avoid using harsh detergents or cosmetics and keep the skin clean. If rash, itching, or hives are severe, consult a doctor.

Other Side Effects

If you are concerned about other side effects, consult a doctor. You may need to change your treatment or stop taking the medication.

Comparison between Studies

Commonalities between Studies

Many studies have shown that one-week triple therapy with omeprazole, clarithromycin, and amoxicillin is effective in eradicating Helicobacter pylori. These treatments have also been shown to be well-tolerated by patients.

Differences between Studies

There are differences in eradication rates and side effect frequencies between studies. This is likely due to differences in the characteristics of the study participants and the details of the treatment regimen. Some studies have suggested that quadruple therapy may be more effective in patients with metronidazole-resistant H. pylori.

Points to Note about Applying to Real Life

One-week triple therapy with omeprazole, clarithromycin, and amoxicillin is an effective treatment for eradicating Helicobacter pylori. However, side effects may occur. If you are concerned about side effects, consult a doctor. Also, do not take these medications on your own. Always follow your doctor's instructions.

Limitations of Current Research

At present, the long-term efficacy and safety of one-week triple therapy with omeprazole, clarithromycin, and amoxicillin have not been fully elucidated. Further research is also needed on the optimal treatment for patients with metronidazole-resistant H. pylori.

Directions for Future Research

Future research should investigate the long-term efficacy and safety of one-week triple therapy with omeprazole, clarithromycin, and amoxicillin. Additionally, it is necessary to develop optimal treatment regimens for patients with metronidazole-resistant H. pylori.

Conclusion

One-week triple therapy with omeprazole, clarithromycin, and amoxicillin is an effective treatment for eradicating Helicobacter pylori. However, side effects may occur. If you are concerned about side effects, consult a doctor. Also, do not take these medications on your own. Always follow your doctor's instructions.

Literature analysis of 29 papers
Positive Content
29
Neutral Content
0
Negative Content
0
Article Type
16
0
0
2
28
1.

One-week therapy with omeprazole, clarithromycin and metronidazole or ornidazole, followed by 3 weeks' treatment with omeprazole, eradicates Helicobacter pylori equally and heals duodenal ulcer.

Author: TzivrasM, ArchimandritisA, BalatsosV, DelisV, SouyioultzisS, SkandalisN, KanellopoulouE, ManikaZ, DavarisP

Duodenal ulcer healing
H. pylori eradication

Triple 1-week regimens of omeprazole, clarithromycin, and a nitroimidazole followed by omeprazole were effective in eradicating H. pylori and healing duodenal ulcers in a country with high metronidazole resistance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Amoxicillin/metronidazole/omeprazole/clarithromycin: a new, short quadruple therapy for Helicobacter pylori eradication.

Author: TreiberG, AmmonS, SchneiderE, KlotzU

H. pylori eradication
Antibiotic resistances

Quadruple therapy regimens for Helicobacter pylori eradication were evaluated, as triple therapy regimens have become the new standard therapy. Triple therapy regimens have success rates of about 90%, but they are still costly, duration is about one week or less, and side-effects are not negligible.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

A randomized controlled comparison of three quadruple therapy regimens in a population with low Helicobacter pylori eradication rates.

Author: SotudehmaneshR, MalekzadehR, FazelA, MassarratS, Ziad-AlizadehB, EshraghianM R

H. pylori eradication

This study compared the efficacy and tolerability of omeprazole/clarithromycin/bismuth/tetracycline-based quadruple therapy to that of ranitidine/metronidazole/bismuth/tetracycline-based quadruple therapy in patients with high prevalence of metronidazole-resistant Helicobacter pylori.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

A prospective randomized trial comparing the use of omeprazole-based dual and triple therapy for eradication of Helicobacter pylori.

Author: ChuK M, ChoiH K, TuenH H, LawS Y, BranickiF J, WongJ

Cost-effective
Effective treatment
Safe
Well tolerated
Side effects

This study found that a one-week course of omeprazole, clarithromycin, and metronidazole was significantly more effective in eradicating Helicobacter pylori than a two-week course of omeprazole and amoxicillin. The study suggests that the triple therapy is a safe, well-tolerated, efficacious, and cost-effective treatment for H. pylori infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Comparison of two 1-week low-dose omeprazole triple therapies--optimal treatment for Helicobacter pylori infection?

Author: GohK L, ParasakthiN, ChuahS Y, CheahP L, LoY L, ChinS C

H. pylori eradication

This study compares the efficacy and tolerability of two 1-week regimens for Helicobacter pylori eradication, one using omeprazole, clarithromycin, and amoxycillin, and the other using omeprazole, clarithromycin, and metronidazole. The influence of bacterial resistance to metronidazole and clarithromycin on treatment outcome was also examined.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Omeprazole once or twice daily with clarithromycin and metronidazole for Helicobacter pylori.

Author: ChibaN, MarshallC P

H. pylori eradication
Mild side effects

Triple therapy with omeprazole, clarithromycin, and metronidazole (OCM) was effective in treating Helicobacter pylori infection, regardless of whether omeprazole was given once or twice daily. The regimens were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Comparison of omeprazole, metronidazole and clarithromycin with omeprazole/amoxicillin dual-therapy for the cure of Helicobacter pylori infection.

Author: MiehlkeS, MeiningA, LehnN, HöchterW, WeingartJ, SimonT, KrämerW, KlannH, BolleK, SommerA, StolteM, BayerdörfferE

H pylori cure
Side effects

A modified omeprazole-based triple therapy was highly effective in curing Helicobacter pylori infection. Combined treatment with omeprazole, clarithromycin and a higher dose of metronidazole was significantly more effective than standard dual therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Omeprazole, clarithromycin and furazolidone for the eradication of Helicobacter pylori in patients with duodenal ulcer.

Author: DaniR, QueirozD M, DiasM G, FrancoJ M, MagalhãesL C, MendesG S, MoreiraL S, De CastroL P, ToppaN H, RochaG A, CabralM M, SallesP G

Eradicates H. pylori
Heals duodenal ulcer
Mild side effects

Clarithromycin and furazolidone in combination with omeprazole are a good alternative for Helicobacter pylori eradication in Brazilian patients with duodenal ulcer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

One week treatment with omeprazole, clarithromycin and tinidazole or lansoprazole, amoxicillin and metronidazole for cure of Helicobacter pylori infection in duodenal ulcer patients.

Author: SitoE, KonturekP C, BielańskiW, KwiecieńN, KonturekS J, BaniukiewiczA, JedynakM, GabryelewiczA, HahnE G

Duodenal ulcer healing
Helicobacter pylori treatment
Taste disturbance

Two different one-week regimens, omeprazole, clarithromycin, and tinidazole or lansoprazole, amoxicillin, and metronidazole, were equally effective in healing duodenal ulcers and eradicating Helicobacter pylori. Both treatments were well tolerated, with only a few patients experiencing taste disturbances.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Efficacy of clarithromycin in eradicating Helicobacter pylori.

Author: SatohK, KimuraK, TakimotoT, KihiraK, TaniguchiY, SaifukuK

H. pylori eradication
Side effects

Clarithromycin is effective in eradicating Helicobacter pylori. Dual therapy with clarithromycin and a proton pump inhibitor achieved eradication rates of 38%-83%, while 1-week triple therapy with omeprazole, clarithromycin, and other antibiotics achieved eradication rates of 80%-96%.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Two-week dual vs. one-week triple therapy for cure of Helicobacter pylori infection in primary care: a multicentre, randomized trial.

Author: CalvetX, López-LorenteM, CubellsM, BarèM, GálvezE, MolinaE

H. pylori eradication

One-week triple therapy (omeprazole, clarithromycin, and amoxycillin) was superior to two-week dual therapy (omeprazole and clarithromycin) for Helicobacter pylori eradication in patients with duodenal ulcer. However, the cure rate in primary care was far below 90%.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Omeprazole-based antimicrobial therapies: results in 198 Helicobacter pylori-positive patients.

Author: DeltenreM, JonasC, van GossumM, BusetM, OteroJ, De KosterE

H. pylori eradication
Side effects

Clarithromycin-based therapies were significantly more effective at eradicating Helicobacter pylori infection than amoxycillin-based therapies.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Sequential therapy versus standard triple drug therapy for eradication of Helicobacter pylori in patients with perforated duodenal ulcer following simple closure.

Author: ValooranGeorge J, KateVikram, JagdishSadasivan, BasuDebdatta

H. pylori eradication

Sequential therapy may be more effective than standard triple therapy in eradicating Helicobacter pylori infection in patients with clarithromycin resistance.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

One-week low-dose triple therapy for the eradication of Helicobacter pylori infection.

Author: LabenzJ, StolteM, RühlG H, BeckerT, TillenburgB, SollböhmerM, BörschG

OCM H. pylori efficacy
OCM H. pylori safety

A 1-week low-dose triple therapy regimen of omeprazole, clarithromycin, and metronidazole was highly effective in eradicating H. pylori and was well tolerated. Replacing metronidazole with tetracycline significantly decreased the eradication rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Levofloxacin- vs. ranitidine bismuth citrate-containing therapy after H. pylori treatment failure.

Author: GisbertJavier P, GisbertJose Luis, MarcosSantiago, Moreno-OteroRicardo, PajaresJose Maria

Alternative to quadruple therapy
Side effects

Both ranitidine bismuth citrate and levofloxacin-containing second-line regimens were effective in treating Helicobacter pylori infection after first-line eradication failure. Both regimens represent alternatives to quadruple therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Helicobacter pylori eradication in clinical practice: one-week low-dose triple therapy is preferable to classical bismuth based triple therapy.

Author: GoddardA F, SpillerR C

High eradication rates

The efficacy and acceptability of both bismuth-based and omeprazole-based triple therapies for Helicobacter pylori eradication in routine clinical practice need further investigation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Furazolidone-based triple therapy for H pylori gastritis in children.

Author: KawakamiElisabete, MachadoRodrigo Strehl, OgataSilvio Kazuo, LangnerMarini, FukushimaErika, CarelliAnna Paula, BonucciVania Cláudia Guimarães, PatricioFrancy Reis Silva

H. pylori eradication
Side effects

Triple therapy with furazolidone achieved moderate efficacy in treating H pylori in children, with a higher eradication rate in patients with duodenal ulcer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Eradication of Helicobacter pylori with lansoprazole, roxithromycin and metronidazole--an open pilot study.

Author: PohleT, StollR, KirchnerT, HeepM, LehnN, BockH, DomschkeW

H. pylori eradication
Safe treatment
Diarrhea
Liver function changes
Metronidazole resistance

The combination of lansoprazole, roxithromycin and metronidazole proved to be as safe as other current triple therapy regimens. In a study of 163 patients with duodenal ulcer and proven H. pylori infection, H. pylori was successfully eradicated in 84.7% of cases as determined by urease quick test, 78.0% by histology, 81.3% by 13C-urea breath test; and in 75.3%, at least two tests were negative.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

[Seven-day omeprazole, clarithromycin, and amoxicillin for the therapy of Helicobacter pylori infection].

Author: CometR, CalvetX, NavarroM, GarcíaN, SanfeliuI

H. pylori eradication
Mild side effects

Seven-day therapy with omeprazole, amoxicillin and clarithromycin achieved an 85% cure rate of H. pylori infection in patients with peptic ulcer disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

21.

Randomized controlled comparison of nitroimidazoles for the eradication of Helicobacter pylori and relief of ulcer-associated and non-ulcer dyspepsia.

Author: GoddardA F, LoganR P, LawesS, SpillerR C

H. pylori eradication

Treatment with omeprazole, clarithromycin, and metronidazole (OCM) is as effective as the more expensive tinidazole regimen (OCT) at eradicating Helicobacter pylori. H. pylori eradication results in long-term relief of dyspeptic symptoms and reduced antisecretory consumption only in patients with duodenal ulcer, and not in those with non-ulcer dyspepsia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Therapy of H. pylori infection.

Author: BazzoliF, PozzatoP

H. pylori eradication
Improved compliance
Reduced side effects

This study evaluated the effectiveness of a 1-week low-dose triple therapy for eradicating H. pylori infection. The regimen consisting of omeprazole, clarithromycin, and tinidazole was highly effective in eradicating H. pylori infection in patients with gastritis, duodenal ulcer, and gastric ulcer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

New one-week, low-dose triple therapy for the treatment of duodenal ulcer with Helicobacter pylori infection.

Author: HuangW H, HoA S, ShyuR Y, LeeS C, LeeM M, HsuC T

Higher eradication rate
Drug resistance
Low compliance
Side-effects

This study compared the efficacy, patient compliance, and cost of short-term PPI-based triple therapy with those of bismuth-based triple therapy for Helicobacter pylori infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

One-week triple therapy with omeprazole, clarithromycin, and nitroimidazole for Helicobacter pylori infection in children and adolescents.

Author: MoshkowitzM, ReifS, BrillS, RingelY, ArberN, HalpernZ, BujanoverY

Peptic ulcer management
Peptic ulcer reduction

A combination of omeprazole, clarithromycin, and tinidazole is highly tolerable and effective in eradicating Helicobacter pylori infection in adults, achieving a success rate of over 90%.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

25.

[Methods to optimize the management of Helicobacter pylori infection. The comparative efficacy of the triple and quadruple therapy used as a first line therapy].

Author: Grigor'evP Ia, IakovenkoA V, IakovenkoE P, Vasil'evI V, KomlevaIu V, OprishchenkoI V, AldiiarovaM A

Hp infection eradication

This study compared the efficacy of triple and quadruple therapies for eradication of Helicobacter pylori infection over a 5-year period. The study found that the quadruple therapy was more effective than the triple therapy.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

26.

Beta-lactamase inhibitor enhances Helicobacter pylori eradication rate.

Author: OjettiV, MignecoA, ZoccoM A, NistaE C, GasbarriniG, GasbarriniA

Effective H. pylori treatment
Antibiotic resistance

One-week triple therapy, the standard treatment for Helicobacter pylori infection, often faces challenges due to increasing resistance. This study highlights the potential advantages of amoxicillin-clavulanate combination over amoxicillin alone and explores the 'in-vitro' antibacterial activity of beta-lactamase inhibitors against H. pylori.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

[Treatment with omeprazole, clarithromycin and amoxicillin for one week. Their efficacy and tolerance in eradicating Helicobacter pylori in primary care].

Author: Baena DíezJ M, Sancho PerpiñánA, López MompóC, Rams RamsF, Jiménez NavarreteS, Comet JaumetD

Easy to apply
H. pylori eradication
Diarrhea
Dysgeusia
Nausea

The triple therapy of omeprazole, amoxycillin and clarithromycin for a week is efficacious in eradicating HP. In a study of 121 patients with peptic ulcer and symptomatic chronic gastritis, eradication was confirmed in 80.2% of cases. Side-effects were light or moderate in all cases: the most common were dysgeusia, nausea and diarrhoea.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Spanish

28.

Efficacy and safety of rifabutin-containing 'rescue therapy' for resistant Helicobacter pylori infection.

Author: BorodyT J, PangG, WettsteinA R, ClancyR, HerdmanK, SuraceR, LlorenteR, NgC

Effective against H. pylori
Well tolerated

A 12-day course of rifabutin with an increased dose of amoxicillin and pantoprazole is well-tolerated and highly effective against dual-resistant H. pylori infection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

29.

[Omeprazole, clarithromycin and amoxicillin therapy for Helicobacter pylori infection].

Author: ChenS, ChenZ, BeiL

Helicobacter pylori eradication
Metallic taste

Triple therapy with omeprazole, clarithromycin, and amoxicillin is an effective and well-tolerated treatment for Helicobacter pylori (Hp) infection.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

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