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Side effects and mortality associated with use of phenytoin for early posttraumatic seizure prophylaxis.

Author: DikmenS S, HaltinerA M, NewellD W, TemkinN R, WinnH R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

The use of phenytoin to prevent early posttraumatic seizures following head injury was evaluated for its association with significant adverse side effects and its effect on mortality rates in head-injured patients.
Paper Details　
Original Abstract of the Article :
The goals of this study were to determine if the use of phenytoin to prevent early posttraumatic seizures following head injury was associated with significant adverse side effects and also to determine if the reduction in early posttraumatic seizures after phenytoin administration was associated wi...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.3171/jns.1999.91.4.0588

データ提供：米国国立医学図書館（NLM）

The Use of Phenytoin for Posttraumatic Seizure Prophylaxis

This study explores the role of phenytoin, an anti-seizure medication, in preventing posttraumatic seizures following head injury. It's like a skilled camel caravan, navigating the treacherous path of brain injury and its potential consequences.

Balancing Benefits and Risks

The researchers investigated the effectiveness of phenytoin in reducing early posttraumatic seizures while also assessing its associated side effects and impact on mortality. It's like analyzing the pros and cons of a desert route, carefully weighing the risks and rewards.

Evaluating Treatment Strategies

The study's findings provide valuable information for healthcare providers, guiding them in making informed decisions regarding the use of phenytoin for posttraumatic seizure prophylaxis. It's like a map with detailed landmarks, helping navigate the complex terrain of brain injury management.

Dr. Camel's Conclusion

This study highlights the importance of carefully evaluating the risks and benefits of medical interventions. It's like a desert traveler choosing the most suitable path, considering all factors before embarking on a journey. This research underscores the need for a balanced approach to treatment, ensuring patient safety and maximizing positive outcomes.

Date :
  1. Date Completed 1999-10-14
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

10507379

DOI: Digital Object Identifier

10.3171/jns.1999.91.4.0588

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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