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Studies on a Hib-tetanus toxoid conjugate vaccine: effects of co-administered tetanus toxoid vaccine, of administration route and of combined administration with an inactivated polio vaccine.

Author: CarlssonR M, ClaessonB A, IwarsonS, KäyhtyH, SelstamU

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A freeze-dried tetanus toxoid (T) conjugated Haemophilus influenzae type b (Hib) vaccine was administered to Swedish infants at three, five and 12 months of age. Antibody responses to Hib, D, T or polio were not negatively influenced by the administration route or by mixing with IPV, except that the mixed vaccine DT-IPV induced lower anti-polio titers after primary vaccination than did separate IPV. More local reactions were induced by the s.c. than by the i.m. route.
Paper Details　
Original Abstract of the Article :
A freeze-dried tetanus toxoid (T) conjugated Haemophilus influenzae type b (Hib) vaccine, was reconstituted in either diphtheria toxoid (D), DT or a combined DT and inactivated polio vaccine (IPV), and administered in an open randomized trial either intramuscularly (i.m. ) or subcutaneously (s.c.) t...See full text at original site
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引用元：
https://doi.org/10.1016/s0264-410x(99)00238-8

データ提供：米国国立医学図書館（NLM）

Hib-Tetanus Toxoid Conjugate Vaccine: Investigating Administration Strategies

The development of effective vaccines is crucial for protecting children from preventable diseases. This study investigates the effectiveness of a Hib-tetanus toxoid conjugate vaccine, exploring the impact of co-administered tetanus toxoid vaccine, different administration routes, and the combined administration with an inactivated polio vaccine. Researchers conducted an open randomized trial on Swedish infants, evaluating antibody responses and local reactions. The study provides valuable insights into the administration protocols and the potential impact of mixing vaccines.

Optimizing Vaccine Administration for Maximum Protection

The study's findings suggest that the Hib-tetanus toxoid conjugate vaccine is effective in inducing antibody responses, regardless of the administration route or the presence of co-administered tetanus toxoid vaccine. The study also highlights the importance of careful consideration when mixing vaccines, as the combination of DT-IPV induced lower anti-polio titers after primary vaccination. This research contributes to the ongoing efforts to optimize vaccine administration strategies to maximize protection and minimize adverse reactions.

Protecting Infants from Preventable Diseases

The development of effective vaccines has significantly reduced the incidence of serious infectious diseases in children. This study emphasizes the importance of ongoing research to refine vaccine administration protocols, ensuring optimal protection for infants and maximizing their chances of a healthy future.

Dr. Camel's Conclusion

Like a camel navigating a vast desert, researchers are carefully navigating the intricate pathways of vaccine development. This study provides valuable insights into optimizing vaccine administration, contributing to the ongoing quest to protect children from preventable diseases.

Date :
  1. Date Completed 2000-01-13
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

10519936

DOI: Digital Object Identifier

10.1016/s0264-410x(99)00238-8

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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