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Effects of risedronate treatment on vertebral and nonvertebral fractures in women with postmenopausal osteoporosis: a randomized controlled trial. Vertebral Efficacy With Risedronate Therapy (VERT) Study Group.

Author: AxelrodD W, BrownJ, ChesnutC H, EriksenE F, GenantH K, HangartnerT, HarrisS T, HoseyniM S, KellerM, McKeeverC D, MillerP D, WattsN B

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Risedronate therapy was effective and well-tolerated in treating postmenopausal women with established osteoporosis.
Paper Details　
Original Abstract of the Article :
CONTEXT: Risedronate, a potent bisphosphonate, has been shown to be effective in the treatment of Paget disease of bone and other metabolic bone diseases but, to our knowledge, it has not been evaluated in the treatment of established postmenopausal osteoporosis. OBJECTIVE: To test the efficacy and...See full text at original site
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引用元：
https://doi.org/10.1001/jama.282.14.1344

データ提供：米国国立医学図書館（NLM）

Risedronate: A New Tool for Fighting Osteoporosis

The field of [bone health] is a complex landscape, with osteoporosis posing a significant challenge for many. This study focuses on risedronate, a [bisphosphonate] medication, and its potential to reduce the risk of fractures in postmenopausal women with osteoporosis. The researchers conducted a [randomized controlled trial] involving a large group of women, comparing the effects of risedronate to placebo. The results demonstrate the effectiveness of risedronate in reducing both vertebral and nonvertebral fractures, showcasing its potential as a powerful tool in the fight against osteoporosis.

Strengthening Bones and Reducing Fractures

The study revealed a significant reduction in the cumulative incidence of new vertebral fractures in the risedronate group compared to placebo, a decrease of 41% over three years. The effect was even more pronounced in the first year, with a 65% reduction in fracture risk. These findings are significant, highlighting the potential of risedronate to reduce the risk of debilitating fractures in women with established osteoporosis.

Healthy Bones, Happy Travels

This study emphasizes the importance of proactive measures to maintain bone health, especially for women after menopause. Risedronate, in conjunction with calcium and vitamin D, offers a promising strategy for reducing the risk of fractures and improving overall bone health. While this study is encouraging, it's essential to consult with a physician to determine the appropriate treatment for each individual.

Dr.Camel's Conclusion

This study, like a sturdy camel navigating the rugged terrain of bone health, showcases the potential of risedronate to combat osteoporosis. The findings are promising, suggesting that risedronate can help strengthen bones and reduce the risk of fractures. As a wise camel knows, maintaining bone health is essential for a strong and healthy journey through life.

Date :
  1. Date Completed 1999-10-27
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

10527181

DOI: Digital Object Identifier

10.1001/jama.282.14.1344

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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