Paper Details

  1. Home
  2. Paper Details

Combination therapy versus monotherapy for the treatment of patients with rheumatoid arthritis.

Author: ApraşS, CalgüneriM, CalişkanerZ, CobankaraV, ErtenliI, KirazS, PayS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Combination therapy with disease-modifying antirheumatic drugs (DMARDs) was found to be more effective than monotherapy in treating rheumatoid arthritis (RA). The combination of methotrexate (MTX), sulfasalazine (SSZ), and hydroxychloroquine (HCQ) was the most effective treatment.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: The response to single disease modifying antirheumatic drug (DMARD) is often suboptimal in patients with rheumatoid arthritis (RA). Thus, despite the limited data on the therapeutic efficacy of combination therapies, many patients are currently treated with a combination of DMARDs. METHO...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/10609068

データ提供：米国国立医学図書館（NLM）

Combination Therapy for Rheumatoid Arthritis: A Journey Through the Desert of Joint Pain

The desert of joint pain can be a desolate place. Rheumatoid arthritis (RA), a chronic autoimmune disease, can cause significant pain, inflammation, and disability. This research explores the effectiveness of combination therapy, using multiple disease-modifying antirheumatic drugs (DMARDs), in treating RA. The researchers conducted a randomized trial comparing monotherapy to combination therapy, hoping to identify a more effective treatment approach for RA patients.

Combination Therapy Shows Promise for Rheumatoid Arthritis

This research demonstrates the superiority of combination therapy over monotherapy in treating rheumatoid arthritis. The study found significant improvements in clinical and laboratory parameters in all three groups. However, the combination of MTX + SSZ + HCQ was significantly more effective than both monotherapy and two-drug combinations.

Navigating the Desert of Joint Pain

The desert of joint pain can be a challenging landscape to navigate. If you are experiencing joint pain, it is essential to consult with your healthcare provider for proper diagnosis and treatment. This research highlights the potential benefits of combination therapy for RA patients, offering hope for those seeking relief in the desert of joint pain.

Dr.Camel's Conclusion

This research, like a guiding star in the desert of joint pain, illuminates the potential of combination therapy for RA patients. It reminds us that in the pursuit of effective treatments, collaboration and innovation are essential.

Date :
  1. Date Completed 2000-01-12
  2. Date Revised 2017-01-12
Further Info :

Pubmed ID

10609068

DOI: Digital Object Identifier

10609068

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.