[Pharmacological profiles of the potent carbonic anhydrase inhibitor dorzolamide hydrochloride, a topical antiglaucoma agent].

Author: KobayashiM, NaitoK

Paper Details 
Original Abstract of the Article :
Carbonic anhydrase (CA) plays an important role in the secretion of aqueous humor. The orally administered CA inhibitor acetazolamide lowers the intraocular pressure (IOP) of patients with glaucoma. However, approximately 50% of patients stop treatment with acetazolamide as a consequence of intolera...See full text at original site
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引用元:
https://doi.org/10.1254/fpj.115.323

データ提供:米国国立医学図書館(NLM)

Dorzolamide Hydrochloride: A Topical Solution for Glaucoma

This study focuses on the pharmacological profile of dorzolamide hydrochloride, a topically active carbonic anhydrase inhibitor, as a potential treatment for glaucoma. The researchers compared the efficacy and safety of dorzolamide with other glaucoma treatments, including oral carbonic anhydrase inhibitors and topical beta-blockers. This study provides a comprehensive overview of the pharmacological properties and clinical efficacy of dorzolamide hydrochloride in treating glaucoma.

Dorzolamide: A Targeted Approach to Lowering Intraocular Pressure

The study demonstrates the effectiveness of dorzolamide in lowering intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension, without inducing the severe systemic adverse events associated with oral carbonic anhydrase inhibitors. This research highlights the potential of dorzolamide as a safe and effective treatment option for glaucoma, offering a targeted approach to IOP reduction.

Glaucoma Management: A Multifaceted Approach

This study underscores the importance of considering a multifaceted approach to glaucoma management, recognizing that different treatment options may be more effective for specific patient needs. It emphasizes the need for ongoing research and development of new therapies to address the diverse challenges associated with this chronic condition. This research encourages a collaborative approach to glaucoma care, involving healthcare professionals, patients, and researchers in finding the most effective solutions.

Dr. Camel's Conclusion

This study is like a refreshing oasis in the desert of glaucoma, offering a new and effective way to manage this challenging condition. It shows that dorzolamide can be a valuable tool in the arsenal of glaucoma treatments, offering a targeted approach to lowering IOP and preserving vision.

Date :
  1. Date Completed 2000-11-24
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

10948564

DOI: Digital Object Identifier

10.1254/fpj.115.323

SNS
PICO Info
in preparation
Languages

Japanese

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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