Paper Details

  1. Home
  2. Paper Details

A comparison of topical application of penciclovir 1% cream with acyclovir 3% cream for treatment of genital herpes: a randomized, double-blind, multicentre trial.

Author: , ChenJ, ChenX S, GuoZ P, HanG Z, LuN Z, WangJ B

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This randomized, double-blind, multicentre trial compared the efficacy of penciclovir 1% cream to acyclovir in treating genital herpes simplex virus (HSV) infection. The study found that penciclovir showed encouraging results, with a shorter time to crusting in patients with primary infections, but no significant differences in overall efficacy.
Paper Details　
Original Abstract of the Article :
Genital herpes simplex virus (HSV) infection, a sexually transmitted disease (STD), is the commonest cause of ulcerative genital infections among the young and adult population. The significant association of genital ulceration and transmission of human immunodeficiency virus (HIV) has been shown in...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1258/0956462001916533

データ提供：米国国立医学図書館（NLM）

Penciclovir vs. Acyclovir: Topical Treatments for Genital Herpes

Genital herpes, a common sexually transmitted infection, can be a challenging desert landscape, often marked by painful outbreaks. This research compares the effectiveness of topical penciclovir cream with topical acyclovir cream in treating genital herpes. The study aims to identify potential differences in their clinical efficacy and safety profiles.

Penciclovir: A Potential Oasis in the Desert of Genital Herpes

The study found that both penciclovir and acyclovir showed encouraging improvements in clinical outcomes, with comparable rates of healing and symptom resolution. It's like finding two reliable oases in the desert, offering potential relief and recovery from the symptoms of genital herpes. While no significant differences in efficacy were observed between the two treatments, penciclovir showed a faster time to crusting in the primary infection group.

Navigating Treatment Options for Genital Herpes

This research provides valuable insights into the potential of topical penciclovir cream as a treatment option for genital herpes. It's like finding a new path through the desert, offering an alternative route to managing this challenging condition. However, further research is needed to fully evaluate the long-term effectiveness and safety of penciclovir in treating genital herpes. As always, consulting a healthcare professional is crucial for making informed treatment decisions.

Dr.Camel's Conclusion

The desert of genital herpes can be a painful and challenging terrain. This research suggests that topical penciclovir cream could offer a potential oasis of relief, providing a comparable level of effectiveness to acyclovir. However, further research is needed to solidify its position as a reliable treatment option. As always, seeking advice from a healthcare professional is essential for making informed treatment choices.

Date :
  1. Date Completed 2001-08-30
  2. Date Revised 2020-12-08
Further Info :

Pubmed ID

10997497

DOI: Digital Object Identifier

10.1258/0956462001916533

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.