Electron and video-light microscopy analysis of the in vitro effects of pyrantel pamoate on Giardia lamblia.

Author: CampanatiL, GadelhaA P, Monteiro-LealL H

Paper Details 
Original Abstract of the Article :
Electron and video-light microscopy analysis of the in vitro effects of pyrantel pamoate on Giardia lamblia. Experimental Parasitology 97, 9-14. Giardia infection is predominant in the small intestine of vertebrates, where the trophozoites attach to epithelial cells and adversely affect the microvil...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/11207109

データ提供:米国国立医学図書館(NLM)

Pyrantel Pamoate's Effects on Giardia Lamblia

This study delves into the intricate world of parasitic infections, specifically focusing on the effects of pyrantel pamoate, a drug commonly used to treat helminthic infections in animals, on Giardia lamblia, a protozoan parasite that can cause gastrointestinal illness in humans. The researchers employed a multifaceted approach, using both electron and video-light microscopy to meticulously examine the effects of pyrantel pamoate on Giardia trophozoites, the active form of the parasite, at various concentrations. Their findings revealed significant changes in Giardia morphology and motility, indicating a potential therapeutic effect of pyrantel pamoate against this parasite.

Pyrantel Pamoate: A Potential Therapeutic Option for Giardiasis

The study's findings suggest that pyrantel pamoate may have therapeutic potential for treating Giardiasis, a common parasitic infection, particularly in developing countries. The observed changes in Giardia morphology and motility, particularly the decrease in flagella beating frequency and alterations in the lateral flange, suggest that pyrantel pamoate may disrupt the parasite's ability to attach to and infect the intestinal lining. This research opens up a new avenue for exploring alternative therapies for Giardiasis, potentially offering a more effective and safer option for patients.

Exploring New Therapies for Parasitic Infections

This research underscores the importance of continued investigation into the potential therapeutic applications of existing medications, particularly those used for treating animal infections. The study's findings offer a glimpse into the vast desert of parasitic infections, revealing that a drug commonly used for animals may hold potential for treating human infections. This research inspires us to continue exploring new frontiers in medicine, seeking innovative solutions for the challenges posed by parasitic diseases.

Dr.Camel's Conclusion

This study reveals the potential of pyrantel pamoate for treating Giardia infections. The observed effects on Giardia morphology and motility suggest that this drug may offer a promising therapeutic option, particularly in regions where Giardiasis is prevalent. As we continue to explore the vast desert of parasitic infections, this research serves as a guiding star, illuminating new pathways for developing more effective and safe treatments.
Date :
  1. Date Completed 2001-03-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

11207109

DOI: Digital Object Identifier

S0014-4894(00)94578-8

Related Literature

SNS
PICO Info
in preparation
Languages

English

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