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Effects of sucralfate on the oral bioavailability of moxifloxacin, a novel 8-methoxyfluoroquinolone, in healthy volunteers.

Author: DelesenH, MöllerJ G, SchühlyU, StassH

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Concomitant administration of sucralfate and moxifloxacin significantly reduced the bioavailability of moxifloxacin. This reduction in bioavailability is likely due to a chelation reaction with polyvalent cations, which is a common finding for quinolones. Therefore, staggered administration of moxifloxacin and Al3+-containing interactants should be considered to avoid subtherapeutic plasma concentrations of the quinolone.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To investigate the effect of concomitant Al3+ (sucralfate) administration on the pharmacokinetics and tolerability of moxifloxacin. DESIGN: This was a single-centre, randomised, nonblinded, 2-way crossover study in healthy volunteers. PARTICIPANTS: 12 healthy men (age 21 to 41 years) we...See full text at original site
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引用元：
https://doi.org/10.2165/00003088-200140001-00007

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Drug Interactions: Moxifloxacin and Sucralfate

In the vast desert of pharmacology, navigating the complex landscape of drug interactions is a crucial endeavor. This study, published in the journal European Journal of Clinical Pharmacology, explores the potential interaction between moxifloxacin, a fluoroquinolone antibiotic, and sucralfate, an antacid.

The researchers investigated the pharmacokinetic effects of co-administering moxifloxacin and sucralfate in healthy volunteers. They examined the impact of sucralfate on the bioavailability, absorption rate, and maximum plasma concentration of moxifloxacin.

A Shifting Landscape: The Impact of Sucralfate on Moxifloxacin

The results of this study revealed that co-administration of sucralfate significantly reduced the bioavailability of moxifloxacin. This finding suggests that sucralfate, due to its interaction with polyvalent cations, may interfere with the absorption of moxifloxacin. This emphasizes the importance of carefully considering drug interactions, especially when prescribing antibiotics, to ensure optimal therapeutic efficacy.

A Desert Oasis of Caution: Avoiding Drug Interactions

This research underscores the importance of understanding potential drug interactions, especially when prescribing medications that are commonly used. Patients and healthcare professionals should be aware of the potential for sucralfate to reduce the bioavailability of moxifloxacin, ensuring that medications are prescribed and administered in a manner that maximizes their therapeutic efficacy.

Dr.Camel's Conclusion

This study highlights the importance of considering potential drug interactions when prescribing medications. The findings demonstrate that sucralfate can significantly reduce the bioavailability of moxifloxacin, emphasizing the need for careful monitoring and consideration of alternative treatment options when necessary.

Date :
  1. Date Completed 2001-09-20
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

11352442

DOI: Digital Object Identifier

10.2165/00003088-200140001-00007

SNS
PICO Info
in preparation
Languages

English

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