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Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermediate, and -resistant pneumococci.

Author: AppelbaumPeter C, DaviesTodd A, JacobsMichael R, NagaiKensuke

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the correlation between amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x of pneumococci and changes in antibiotic susceptibility. Alterations in PBP active binding sites were found to correlate with decreased affinities for penicillin, ampicillin, amoxicillin, cefaclor, cefprozil, and cefuroxime.
Paper Details　
Original Abstract of the Article :
Amino acid alterations in or flanking conserved motifs making up the active binding sites of penicillin-binding proteins (PBPs) 1a, 2b, and 2x of pneumococci were correlated with changes in affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor for these P...See full text at original site
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引用元：
https://doi.org/10.1128/AAC.46.5.1273-1280.2002

データ提供：米国国立医学図書館（NLM）

Penicillin-Binding Proteins: A Journey Through the Sands of Pneumococcal Resistance

Pneumococcal infections are a significant public health concern, and the emergence of antibiotic resistance poses a growing threat. This study delves into the intricate world of penicillin-binding proteins (PBPs), key targets for penicillin-based antibiotics. The authors investigated the impact of amino acid alterations in PBPs on the susceptibility of pneumococci to various penicillin derivatives. Their research provides crucial insights into the mechanisms of resistance and the evolution of antibiotic resistance.

Pneumococcal Resistance: A Shifting Landscape

The study revealed a correlation between specific amino acid alterations in PBPs and reduced susceptibility to penicillin and its derivatives. The presence of specific substitutions in PBP1a, -2x, and -2b was associated with increased resistance levels. These findings underscore the importance of understanding these molecular mechanisms to develop more effective antibiotics and combat drug resistance.

A Desert Oasis of Knowledge: Fighting Antibiotic Resistance

This research highlights the ongoing challenge of antibiotic resistance. By understanding the mechanisms of resistance, scientists can design new drugs that circumvent these resistance pathways and restore the effectiveness of existing antibiotics. This study serves as a reminder of the importance of continued research and development in the fight against antibiotic resistance.

Dr.Camel's Conclusion

Pneumococcal resistance is a formidable sandstorm that threatens our ability to treat these infections. This research offers a detailed map of the molecular pathways involved in resistance, providing valuable insights for developing new strategies to combat this growing challenge.

Date :
  1. Date Completed 2002-08-06
  2. Date Revised 2021-12-09
Further Info :

Pubmed ID

11959556

DOI: Digital Object Identifier

10.1128/AAC.46.5.1273-1280.2002

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Languages

English

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