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Immunogenicity and efficacy of Fermi-type nerve tissue rabies vaccine in mice and in humans undergoing post-exposure prophylaxis for rabies in Ethiopia.

Author: AyeleW, BeyeneM, BogaleY, EgziabherF G, FekaduM, MochaK, ZewdieB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the immunogenicity and efficacy of a Fermi-type rabies vaccine in mice and humans. In mice, the vaccine induced protective levels of rabies virus neutralizing antibodies (VNA). Booster doses did not significantly enhance the immune response. In humans, most patients receiving the vaccine had detectable VNA levels by day 14. The study provides the first documentation of the efficacy and immunogenicity of this specific rabies vaccine in both humans and mice.
Paper Details　
Original Abstract of the Article :
Rabies is an acute viral encephalitis that is invariably fatal following the manifestations of clinical signs. To subvert the course of the disease, rabies post-exposure prophylaxis (PEP) is widely utilized. The immunogenicity and efficacy of Fermi-type rabies vaccine produced in Ethiopia was determ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12380231

データ提供：米国国立医学図書館（NLM）

The Power of Vaccination: Ensuring Protection Against Rabies

This research delves into the world of rabies prevention, focusing on the efficacy of a specific type of rabies vaccine. Imagine a camel caravan traveling through a desert, vulnerable to attacks from wild animals. Vaccines serve as a protective shield, preventing the spread of disease. The authors evaluated the immunogenicity and efficacy of a Fermi-type rabies vaccine in mice and humans. They found that the vaccine effectively induced an immune response in both species, demonstrating its potential for protecting against rabies infection. The study highlights the importance of vaccination in preventing rabies, a potentially fatal disease.

The Effectiveness of Rabies Vaccination

This research confirms the effectiveness of rabies vaccination in preventing this potentially fatal disease. The study demonstrates that the Fermi-type rabies vaccine effectively triggers an immune response, providing protection against rabies infection. This underscores the importance of vaccination as a key strategy for public health.

Practical Implications for Public Health

The study's findings emphasize the crucial role of vaccination in public health. By promoting widespread vaccination, we can significantly reduce the incidence of rabies and protect individuals from this potentially deadly disease. This research reinforces the importance of public health initiatives that promote vaccination and ensure access to this vital preventative measure.

Dr. Camel's Conclusion

This research, like a protective oasis shielding travelers from the dangers of the desert, highlights the importance of vaccination in preventing rabies. The study's findings demonstrate the effectiveness of the Fermi-type rabies vaccine, offering a vital tool for safeguarding against this deadly disease. Remember, just as a camel needs protection from the harsh desert environment, we need vaccines to protect ourselves from infectious diseases.

Date :
  1. Date Completed 2002-11-26
  2. Date Revised 2016-11-24
Further Info :

Pubmed ID

12380231

DOI: Digital Object Identifier

12380231

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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