Effects of propranolol (infantile hemangioma): A Synthesis of Findings from 13 Studies

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Original Abstract of the Article

Major Research Findings

Research on the effects of propranolol for infantile hemangioma has revealed several important findings about its mechanism and safety. 12 suggested the potential of Osmundacetone (OSC) as a new treatment for infantile hemangiomas (IH), the most common benign tumors in infancy. The study found that OSC inhibits angiogenesis of IH by inducing caspases and reducing VEGFR2/MMP2. This finding suggests that OSC could be a promising alternative treatment for IH. Another study, 13 , investigated the effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells (HemECs). The study found that propranolol inhibited glucose metabolism in HemECs by suppressing glucose metabolic pathways, particularly glycolysis. This finding provides further evidence for the mechanism by which propranolol works to inhibit hemangioma growth. 10 compared the efficacy and safety of oral atenolol and propranolol for infantile hemangioma. The study concluded that atenolol may be a valid treatment alternative to propranolol, although further research is needed to confirm this finding. These studies provide valuable information about the therapeutic effects of propranolol on infantile hemangioma, its mechanism of action, and the potential for alternative treatments.

Benefits and Risks

Benefit Summary

Propranolol is widely used as an effective treatment for infantile hemangioma. Research shows that propranolol can inhibit hemangioma growth and reduce hemangioma size. Additionally, propranolol is expected to have the effect of preventing complications of hemangiomas. 12 , 13

Risk Summary

Propranolol can cause side effects. The most common side effects are hypoglycemia, decreased heart rate, and difficulty breathing. 11 reported a case of severe side effects due to propranolol overdose. Propranolol may not be used for patients with pre-existing conditions such as heart disease or asthma. The use of propranolol should be done cautiously and under the guidance of a physician.

Comparison Between Studies

Commonalities Between Studies

These studies all investigated the effects of propranolol on infantile hemangioma. They all suggest that propranolol is an effective treatment for infantile hemangioma.

Differences Between Studies

These studies differ in the type of propranolol used, the age of patients studied, and the study design. 12 suggested the potential of Osmundacetone as a new treatment, but this treatment was not investigated in other studies. Also, 10 compared propranolol and atenolol, but this comparison was not performed in other studies.

Consistency and Contradictions in Results

While these studies indicate the effectiveness of propranolol for infantile hemangioma, its mechanism of action and safety are not fully understood. Further research is needed to understand the long-term effects of propranolol. These studies suggest that more research is needed to better understand the safety and efficacy of propranolol.

Considerations for Applying the Results in Real Life

Treatment with propranolol for infantile hemangioma should be done carefully under the guidance of a physician. Propranolol can cause side effects. Propranolol may not be used in patients with pre-existing conditions such as heart disease or asthma. Propranolol should be used cautiously and under the guidance of a physician.

Limitations of Current Research

These studies were conducted with relatively small sample sizes. Therefore, it is unclear whether these findings apply to all people. Additionally, these studies did not examine the long-term effects of propranolol. Further research on the long-term effects of propranolol is necessary.

Future Research Directions

Larger-scale studies are needed to better understand the effects of propranolol on infantile hemangioma. Research is also needed to examine the long-term effects of propranolol. Further research is needed to develop strategies to reduce the side effects of propranolol.

Conclusion

Research on the effects of propranolol for infantile hemangioma suggests that propranolol can inhibit hemangioma growth and reduce hemangioma size. However, propranolol can also cause side effects, so its use requires caution. Propranolol should be used cautiously and under the guidance of a physician. Further research on the treatment of infantile hemangioma is needed, and the development of safer and more effective treatments is anticipated.

Literature analysis of 13 papers
Positive Content
11
Neutral Content
2
Negative Content
0
Article Type
8
1
1
0
13
1.

[Comparison of PVRV and HDCV rabies vaccines as to immunity, reliability and protective value].

Author: HacibektaşoğluA, InalA, EyigünC, BarutA, TürkayF A

Rabies prophylaxis
Fever
Local pain
Lymphadenopathy

PVRV and HDCV vaccines for rabies were equally effective in inducing neutralizing antibodies in healthy male volunteers. Both vaccines provided a year-long protection until the first booster dose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Turkish

2.

Immunoenhancement with combined rabies and aluminium-adjuvanted tetanus vaccines.

Author: PhanuphakP, KhaoplodP, SriwanthanaB, PhanpanichT, WonguraiS, RoumiantzeffM

immunoenhancement
vaccine efficacy increase

Combining tetanus toxoid with purified Vero cell rabies vaccine (PVRV) in the 2-1-1 regimen significantly increased anti-rabies antibody levels, but only when aluminum hydroxide-adsorbed tetanus toxoid was used. This combination did not affect anti-tetanus antibody levels or increase side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Anti-rabies treatment of dog-bite victims in Lagos, Nigeria: trial of suckling mouse brain and fetal bovine kidney cell rabies vaccines.

Author: HarryT O, AdeigaA, AnyiwoC E, NasidiA

Prevents rabies
Generalized reactions
Local reactions

Suckling mouse brain (SMBV) and fetal bovine kidney (FBKV) rabies vaccines were equally efficacious and well tolerated in dog-bite victims.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

Immunogenicity and safety in adults of a new chromatographically purified Vero-cell rabies vaccine (CPRV): a randomized, double-blind trial with purified Vero-cell rabies vaccine (PVRV).

Author: LangJ, CetreJ C, PicotN, LantaM, BriantaisP, VitalS, Le MenerV, LutschC, RotivelY

Rabies vaccination
Asthenia

A new chromatographically purified rabies vaccine (CPRV) was found to be as immunogenic as purified Vero cell vaccine (PVRV) and associated with fewer systemic reactions in a randomized, double-blind study.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Immunogenicity and efficacy of Fermi-type nerve tissue rabies vaccine in mice and in humans undergoing post-exposure prophylaxis for rabies in Ethiopia.

Author: AyeleW, FekaduM, ZewdieB, BeyeneM, BogaleY, MochaK, EgziabherF G

Rabies prophylaxis

This study assessed the immunogenicity and efficacy of a Fermi-type rabies vaccine in mice and humans. In mice, the vaccine induced protective levels of rabies virus neutralizing antibodies (VNA). Booster doses did not significantly enhance the immune response. In humans, most patients receiving the vaccine had detectable VNA levels by day 14. The study provides the first documentation of the efficacy and immunogenicity of this specific rabies vaccine in both humans and mice.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Sex-differential non-specific effects of rabies vaccine in dogs: An extended analysis of a randomized controlled trial in a high-mortality population.

Author: KnobelDarryn L, AregaSintayehu M, ConanAnne

All-cause mortality

This study found a significant sex-specific effect of non-live rabies vaccination on all-cause mortality in a high-mortality dog population. Primary vaccination increased the hazard of death among females, while a second dose decreased the hazard among males. These findings highlight the importance of considering sex-specific effects when evaluating vaccine efficacy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Non-specific effects of maternal and offspring rabies vaccination on mortality and antibiotic use in a Danish pig herd: A randomized trial.

Author: JensenKristoffer Jarlov, TolstrupLola Kathe, KnobelDarryn L, AabyPeter, JungersenGregers, LarsenLars Erik, KristensenCharlotte Sonne, BennChristine Stabell

Rabies vaccination
Non-specific effects

This study investigated the non-specific effects (NSE) of rabies vaccine in piglets, particularly the potential modifying effect of maternal priming with the vaccine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Non-specific effects of rabies vaccine on the incidence of self-reported common infectious disease episodes: A randomized controlled trial.

Author: OditaChristianah I, ConanAnne, Smith-AntonyMarshalette, BatticeJuliet, EnglandShianne, BarryDonna, GessnerBradford D, KnobelDarryn L

This randomized controlled trial investigated whether a rabies vaccine could protect against other common infections. The results showed no significant difference in the incidence of common infections between vaccinated and unvaccinated participants. This suggests that the rabies vaccine does not offer broad protection against other infections.

Clinical Trial, Phase IVPost-marketing surveillance. Monitors long-term safety/efficacy after approval.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Immunogenicity and safety of human diploid cell vaccine (HDCV) vs. purified Vero cell vaccine (PVRV) vs. purified chick embryo cell vaccine (PCECV) used in post-exposure prophylaxis: a systematic review and meta-analysis.

Author: WangShi-Yuan, SunJin-Fang, LiuPei, LuoLi, LiJing-Xin, ZhuFeng-Cai, ShenXu-Xiang, MengFan-Yue

Rabies prevention
Adverse reactions

Human diploid cell vaccine (HDCV) was found to be safer than purified vero cell vaccine and PCECV in terms of adverse reactions. However, no significant difference was observed in terms of immunogenicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Excessively High Chronic Propranolol Overdose in Infantile Hemangioma: A Case Report.

Author: AlshammariHeba, AlessaAlhanouf, ElsharawyYasmin, AlghanemAshjan, AlhammadAbdullah M

Hemangioma treatment
Propranolol overdose

This case report describes a 7-month-old girl who received a chronic propranolol overdose, approximately 8 times the recommended dose, for 2 months. The patient remained asymptomatic, and the overdose was successfully managed with gradual tapering over several weeks.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Osmundacetone Inhibits Angiogenesis of Infantile Hemangiomas through Inducing Caspases and Reducing VEGFR2/MMP2.

Author: KeChen, ChenChanghan, YangMing, ChenHao, LiLiqun, KeYouhui

IH treatment
Drug resistance
Side effects

This study explores the potential of Osmundacetone (OSC) as a new treatment for infantile hemangiomas (IH).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Effects of propranolol on glucose metabolism in hemangioma-derived endothelial cells.

Author: YangKaiying, LiXin, QiuTong, ZhouJiangyuan, GongXue, LanYuru, JiYi

IH treatment

This study investigates the metabolic changes in hemangioma-derived endothelial cells (HemECs) after propranolol treatment, revealing that propranolol inhibits glucose metabolism by suppressing glycolysis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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