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[N-acetylcystein in the therapy of chronic bronchitis].

Author: ReichenbergerF, TammM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study found that adding N-acetylcysteine (NAC) to standard antibiotic treatment for acute exacerbations of chronic bronchitis (CB) significantly increased bacterial eradication rates (70% vs 36%). While NAC has been used as a mucus thinner, its antioxidant effects and impact on bacterial colonization in the lungs suggest that it may be beneficial for treating CB. While further studies are ongoing, NAC may help reduce the frequency and duration of exacerbations, improve lung function, and enhance quality of life for patients with CB.
Paper Details　
Original Abstract of the Article :
Chronic bronchitis (CB) shows an increasing global morbidity and mortality with major impact on socioeconomics. N-Acetylcysteine (NAC), previously used as a mucolytic compound in CB, has also antioxidative effects. Furthermore it influences intrabronchial bacterial colonisation. In a randomised pilo...See full text at original site
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引用元：
https://doi.org/10.1055/s-2002-36122

データ提供：米国国立医学図書館（NLM）

N-acetylcysteine (NAC) for Chronic Bronchitis: A Mucolytic and Antioxidant

Chronic bronchitis (CB) is a common respiratory ailment, causing significant morbidity and mortality worldwide. Traditional treatments have focused on managing symptoms and reducing exacerbations. However, recent research has explored the potential of N-acetylcysteine (NAC) as a promising therapeutic agent for CB.

NAC, previously known for its mucolytic properties, also possesses antioxidant effects and influences bacterial colonization in the airways. A pilot study found that adding NAC to standard antibiotic therapy significantly increased the bacterial eradication rate in patients with acute exacerbations of CB.

NAC's Potential Benefits for CB

Further studies have suggested that NAC may reduce the number and duration of acute exacerbations, potentially improving lung function and quality of life. This is like finding a hidden spring in the desert, providing relief from the harsh conditions.

NAC: A Promising Hope for CB

The potential of NAC as an antioxidant and its positive effects on CB make it a promising therapeutic agent. However, further placebo-controlled studies are underway to definitively establish its role in the treatment of CB and COPD.

Dr.Camel's Conclusion

NAC is like a desert nomad who has discovered a new oasis, bringing relief and hope for those suffering from chronic bronchitis.

Date :
  1. Date Completed 2003-03-26
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

12486618

DOI: Digital Object Identifier

10.1055/s-2002-36122

SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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