Effective treatment of chronic bronchitis: A Synthesis of Findings from 25 Studies

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Original Abstract of the Article

Main research findings

Several treatments for chronic bronchitis have been studied, including N-acetylcysteine (NAC) 5 , antibiotics 20 , the combination of theophylline and salbutamol 6 , erdosteine 21 , fluoroquinolone antibiotics (prulifloxacin and ciprofloxacin) 15 , cefprozil 12 , oxitropium bromide 9 , clarithromycin 19 , farcosolvin syrup 22 , intermittent positive pressure ventilation (IPPV) 2 , sparfloxacin 10 , levofloxacin 16 , salbutamol and ipratropium bromide 3 , cefaclor 14 , cefdinir and cefuroxime 11 , positive expiratory pressure (PEP) 4 , glycopyrrolate 25 , tetracycline 7 , azidocillin 8 , dirithromycin and azithromycin 18 , ipratropium bromide, salbutamol, and prednisolone 1 , and clarithromycin 13 . These studies show that some treatments are effective in improving symptoms, preventing exacerbations, and maintaining lung function in chronic bronchitis. For example, NAC may help reduce the number of exacerbations 5 , and short-course antibiotic treatment has been shown to be as effective as traditional longer treatment 20 . Erdosteine has been shown to be helpful in improving symptoms and overall treatment effect 21 . Also, PEP may help reduce cough and mucus production, and reduce the frequency of exacerbations 4 . However, the effectiveness of these treatments may vary from person to person, and not everyone will experience the same results. Additionally, some treatments may have side effects, and it is important to use them as directed by your doctor.

Treatment summary

NAC may help reduce the number of exacerbations 5 . Short-course antibiotic treatment has been shown to be as effective as traditional longer treatment 20 . The combination of theophylline and salbutamol has been shown to be more effective than placebo 6 . Erdosteine has been shown to be helpful in improving symptoms and overall treatment effect 21 . Prulifloxacin and ciprofloxacin have been shown to be effective in treating exacerbations 15 . Cefprozil has been shown to be as effective as clarithromycin 12 . Oxitropium bromide may affect airway secretions 9 . Clarithromycin has been shown to be effective in treating acute bacterial exacerbations 19 . Farcosolvin syrup has been shown to be effective in treating exacerbations 22 . Intermittent positive pressure ventilation (IPPV) has not been shown to be effective in treating chronic bronchitis 2 . Sparfloxacin has been shown to be as effective as ofloxacin 10 . Levofloxacin has been shown to be as effective as clarithromycin and cefuroxime 16 . Salbutamol and ipratropium bromide have been shown to be effective in treating chronic bronchitis 3 . Cefaclor has been shown to be as effective as cefuroxime 14 . Cefdinir has been shown to be as effective as cefuroxime 11 . PEP may help reduce cough and mucus production, and reduce the frequency of exacerbations 4 . Glycopyrrolate may affect lung function and health-related QOL 25 . Tetracycline may help reduce the frequency of exacerbations 7 . Azidocillin may be superior to cotrimoxazole 8 . Dirithromycin and azithromycin have been shown to be effective in treating exacerbations 18 . Ipratropium bromide, salbutamol, and prednisolone have been shown to be effective in treating chronic bronchitis 1 . Clarithromycin may help improve symptoms of exacerbations 13 .

Benefits and Risks

Benefit Summary

Potential benefits of treatment for chronic bronchitis include improvement in symptoms, prevention of exacerbations, and maintenance of lung function.

Risk Summary

Treatment for chronic bronchitis may have side effects. Side effects can include digestive problems, nervous system problems, and photosensitivity reactions.

Comparison between studies

Commonalities of studies

Many studies used antibiotics, bronchodilators, and mucolytics as treatments for chronic bronchitis.

Differences in studies

Studies differ in the drugs and treatments used, as well as in the study participants. This can make it difficult to directly compare research results.

Consistency and contradiction of results

The effectiveness of treatments for chronic bronchitis is consistent in some research results, while inconsistencies can be found in others. For example, NAC may help reduce the number of exacerbations 5 , but other studies show that it is ineffective. This is likely due to differences in the study participants, the amount of NAC used, and the study design.

Notes on applying results to real life

There are several things to keep in mind when applying treatments for chronic bronchitis to your daily life. First, it is important to choose the right treatment for your symptoms and medical condition. Second, it is important to consult a doctor before starting any treatment and follow their instructions. Additionally, it is important to see your doctor for regular checkups during treatment.

Limitations of current research

There are several limitations to research on treatments for chronic bronchitis. For example, the number of study participants may be small, the study design may have issues, and the research may focus on specific drugs and treatments.

Future research directions

Research on treatments for chronic bronchitis should be conducted with a larger number of participants, over longer periods, and with more rigorous designs. Additionally, research is needed to clarify how specific drugs and treatments work and which patients benefit from them.

Conclusion

Treatments for chronic bronchitis vary depending on symptoms, medical condition, and the patient. Therefore, it is important to consult your doctor when choosing a treatment. By following your doctor's instructions, you can expect to see improvements in your symptoms, prevention of exacerbations, and maintenance of lung function.

List of treatments

N-acetylcysteine, antibiotics, theophylline, salbutamol, erdosteine, fluoroquinolone antibiotics, cefprozil, oxitropium bromide, clarithromycin, farcosolvin syrup, intermittent positive pressure ventilation, sparfloxacin, levofloxacin, salbutamol, ipratropium bromide, cefaclor, cefdinir, positive expiratory pressure, glycopyrrolate, tetracycline, azidocillin, dirithromycin, azithromycin, ipratropium bromide, salbutamol, prednisolone, and clarithromycin.

Literature analysis of 25 papers
Positive Content
23
Neutral Content
2
Negative Content
0
Article Type
21
3
1
2
25
1.

Ipratropium bromide, salbutamol and prednisolone in bronchial asthma and chronic bronchitis.

Author: LightbodyI M, IngramC G, LeggeJ S, JohnstonR N

Asthma treatment
Bronchitis treatment

Ipratropium bromide and salbutamol showed similar improvements in patients with bronchial asthma and chronic bronchitis. Combining both drugs doubled the FEV1 change.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Physiotherapy and intermittent positive-pressure ventilation of chronic bronchitis.

Author: NewtonD A, BevansH G

A study of patients with chronic bronchitis found that intermittent positive-pressure ventilation (IPPV) did not provide any additional benefit over standard drug treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Bronchodilator treatment in moderate asthma or chronic bronchitis: continuous or on demand? A randomised controlled study.

Author: van SchayckC P, DompelingE, van HerwaardenC L, FolgeringH, VerbeekA L, van der HoogenH J, van WeelC

Improved quality of life
Accelerated decline in FEV1

Continuous bronchodilator treatment without anti-inflammatory treatment accelerated decline in ventilatory function in patients with asthma and chronic bronchitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Long-term treatment of chronic bronchitis with positive expiratory pressure mask and chest physiotherapy.

Author: ChristensenE F, NedergaardT, DahlR

Preserved lung function
Reduced antibiotic use
Reduced cough
Reduced exacerbations
Reduced mucus production

This study compared the effectiveness of chest physiotherapy with positive expiratory pressure (PEP) to chest physiotherapy alone in 43 patients with chronic bronchitis. The PEP group experienced significantly fewer exacerbations (85% vs. 48%), reduced coughing and mucus production, and used less medication. The PEP group also showed a small increase in lung function compared to a slight decrease in the control group. The study suggests that PEP can reduce the severity and frequency of symptoms in patients with chronic bronchitis and potentially slow the decline in lung function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Oral Fabrol (oral N-acetyl-cysteine) in chronic bronchitis.

Author: ParrG D, HuitsonA

Incapacitation reduction
NAC tolerability

This study investigated the effectiveness of N-acetylcysteine (NAC) in reducing exacerbations (worsening of symptoms) in 526 patients with chronic bronchitis. Patients were randomly assigned to receive either NAC or placebo for six months. The study found no significant difference in the number of exacerbations between the two groups. However, patients taking NAC had fewer days of incapacitation due to their symptoms. The study concludes that while NAC may not reduce the number of exacerbations, it can improve the overall experience for patients with chronic bronchitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

The efficacy of orally administered theophylline, inhaled salbutamol, and a combination of the two as chronic therapy in the management of chronic bronchitis with reversible air-flow obstruction.

Author: TaylorD R, BuickB, KinneyC, LowryR C, McDevittD G

Bronchodilator therapy
Combined therapy effective

A study of 25 patients with chronic bronchitis and varying degrees of airway obstruction compared the effectiveness of theophylline, inhaled salbutamol, a combination of both, and placebo. The combination therapy was most effective, with only 1 patient requiring additional treatment compared to 9 with placebo, 8 with salbutamol, and 6 with theophylline. The combination therapy also showed significant improvements in lung function, while theophylline was slightly better than placebo, but salbutamol was not. Patients who tolerated placebo did not report subjective benefits from any of the active treatments. These findings suggest that combining theophylline and inhaled salbutamol is a more effective treatment option for chronic bronchitis with airway obstruction compared to individual medications.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Five-year winter chemoprophylaxis for chronic bronchitis.

Author: JohnstonR N, McNeillR S, SmithD H, DempsterM B, NairnJ R, PurvisM S, WatsonJ M, WardF G

Reduced exacerbations

A study of 79 patients with chronic bronchitis compared the effects of long-term tetracycline treatment to placebo. The study found that tetracycline significantly reduced the number of exacerbations in patients who experienced more than one exacerbation per winter. While tetracycline showed a trend towards less decline in lung function over five years, this difference was not statistically significant. There were no significant differences between groups in lung volumes, diffusing capacity, or blood gases. The study concludes that long-term tetracycline treatment may reduce exacerbations in patients with chronic bronchitis who are more prone to flare-ups.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

[Treatment of chronic bronchitis with azidocillin and co-trimoxazole].

Author: GonschewskiH H, StempelG

In a study of 84 people with chronic bronchitis, azidocillin was more effective than co-trimoxazole in treating the condition, although the difference was not statistically significant. Azidocillin was particularly superior in overall physician assessment, which included clinical progress and sputum characteristics. While it is generally safe to start treatment without examining the sputum, in severe cases with life-threatening complications, examining the sputum and starting treatment with a bactericide like azidocillin immediately is recommended, pending the results of the culture.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

9.

Effect of long term treatment with oxitropium bromide on airway secretion in chronic bronchitis and diffuse panbronchiolitis.

Author: TamaokiJ, ChiyotaniA, TagayaE, SakaiN, KonnoK

Improved lung function

The effects of oxitropium bromide on sputum volume and physical properties in patients with chronic bronchitis were investigated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Sparfloxacin vs ofloxacin in the treatment of acute bacterial exacerbations of chronic bronchitis: a multicenter, double-blind, randomized, comparative study. Sparfloxacin Multicenter ABECB Study Group.

Author: DeAbateC A, HenryD, BenschG, JubranA, ChodoshS, HarperL, TippingD, TalbotG H

ABECB treatment
Digestive side effects
Nervous system side effects
Photosensitivity

Once-daily oral sparfloxacin is as effective as twice-daily ofloxacin for treating acute bacterial exacerbations of chronic bronchitis (ABECB). Both drugs are well-tolerated with similar adverse event profiles.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

International study comparing cefdinir and cefuroxime axetil in the treatment of patients with acute exacerbation of chronic bronchitis.

Author: Van HerwaardenC L, LanganC E, SiemonG, RudolphC, KeyserlingC H, NemethM A, TackK J

Antibiotic efficacy
Chronic bronchitis treatment
Antibiotic tolerability
Side effects

The efficacy and tolerability of cefdinir, once or twice daily, and cefuroxime were comparable with no significant differences between the regimens used.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Five days of cefprozil versus 10 days of clarithromycin in the treatment of an acute exacerbation of chronic bronchitis.

Author: McCartyJ M, PierceP F

Cure rate
Diarrhea
Nausea

Cefprozil given for 5 days was as effective as clarithromycin given for 10 days in the treatment of acute exacerbation of chronic bronchitis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Symptom resolution assessed using a patient directed diary card during treatment of acute exacerbations of chronic bronchitis.

Author: WoolhouseI S, HillS L, StockleyR A

Improved understanding of chronic bronchitis

Acute flare-ups of chronic bronchitis are common, with varying symptoms. It is unclear how these symptom differences should affect treatment. Understanding how quickly symptoms improve is important for assessing treatment success and determining when a change in treatment is needed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Comparative study of cefaclor AF vs. cefuroxime axetil in acute exacerbations of chronic bronchitis.

Author: HaczyńskiJózef, ChyczewskaElzbieta, Grzelewska-RzymowskaIwona, MalolepszyJózef, Marcinkowska-SuchowierskaEwa, MilanowskiJanusz, OklekKazimierz, PłusaTadeusz, SłominskiJan, SzmyginKatarzyna, RekMiroslaw

AECB treatment
Difficult choice of therapy

Acute exacerbations of chronic bronchitis are common and often caused by infection. Choosing the right antibiotic treatment for these exacerbations is becoming more challenging and is often done without specific testing. Cefaclor and cefuroxime are commonly used antibiotics for treating these exacerbations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Randomized, double-blind study of prulifloxacin versus ciprofloxacin in patients with acute exacerbations of chronic bronchitis.

Author: GrassiCarlo, SalvatoriEnrica, RosignoliMaria Teresa, DionisioPaolo,

Eradicated strains
Improved clinical success

This randomized, multicenter, double-blind, double-dummy trial assessed the efficacy and safety of prulifloxacin in comparison with ciprofloxacin in 235 patients with acute exacerbations of chronic bronchitis (AECB). Patients received either 600 mg prulifloxacin once daily or 500 mg ciprofloxacin twice a day for 10 days. Clinical success was observed in 84.7% and 85% of patients in the prulifloxacin and ciprofloxacin groups, respectively. The study showed that a 10-day course of prulifloxacin is as effective and safe as ciprofloxacin in the treatment of patients with AECB.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Open-label, randomized comparison of the efficacy and tolerability of clarithromycin, levofloxacin, and cefuroxime axetil in the treatment of adults with acute bacterial exacerbations of chronic bronchitis.

Author: WeissLee R

ABECB treatment effective
Adverse events

Clarithromycin, levofloxacin, and cefuroxime axetil are all effective and well-tolerated treatments for acute bacterial exacerbations of chronic bronchitis (ABECB). While clarithromycin appears to be slightly more effective and better tolerated, the differences between the three treatments are not significant.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

[N-acetylcystein in the therapy of chronic bronchitis].

Author: ReichenbergerF, TammM

CB treatment

This study found that adding N-acetylcysteine (NAC) to standard antibiotic treatment for acute exacerbations of chronic bronchitis (CB) significantly increased bacterial eradication rates (70% vs 36%). While NAC has been used as a mucus thinner, its antioxidant effects and impact on bacterial colonization in the lungs suggest that it may be beneficial for treating CB. While further studies are ongoing, NAC may help reduce the frequency and duration of exacerbations, improve lung function, and enhance quality of life for patients with CB.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

18.

A comparison of 5-day courses of dirithromycin and azithromycin in the treatment of acute exacerbations of chronic obstructive pulmonary disease.

Author: CastaldoRichard S, CelliBartolome R, GomezFernando, LaValleeNicole, SouhradaJoseph, HanrahanJohn P

AECB treatment

The study discussed the use of macrolide antibiotics, particularly dirithromycin and azithromycin, in treating acute exacerbations of chronic bronchitis (AECB).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Role for 5-day, once-daily extended-release clarithromycin in acute bacterial exacerbation of chronic bronchitis.

Author: GotfriedMark, BusmanTodd A, NorrisSandra, NotarioGerard F

Improved ABECB treatment
Reduced treatment costs
Acute bacterial exacerbation of chronic bronchitis

Clarithromycin is typically prescribed for a week or longer to treat acute bacterial exacerbations of chronic bronchitis (ABECB). However, studies on other antibiotics suggest that shorter treatment courses may be just as effective, with fewer side effects, better adherence, greater patient satisfaction, and lower costs.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

20.

Short-course antibiotic treatment in acute exacerbations of chronic bronchitis and COPD: a meta-analysis of double-blind studies.

Author: El MoussaouiR, RoedeB M, SpeelmanP, BresserP, PrinsJ M, BossuytP M M

Effective treatment

A short course of antibiotic treatment was as effective as the traditional longer treatment in patients with mild to moderate exacerbations of chronic bronchitis and COPD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

21.

The therapeutic efficacy of erdosteine in the treatment of chronic obstructive bronchitis: a meta-analysis of individual patient data.

Author: CazzolaM, FlorianiI, PageC P

Improved Respiratory Function
Improved Sputum Viscosity
Reduced Cough Symptoms
Gastrointestinal Side Effects

Erdosteine, a drug used to treat chronic bronchitis or COPD (CB/COPD), significantly improved symptoms compared to placebo or mucolytics. The treatment was well tolerated.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

22.

Clinical efficacy of farcosolvin syrup (ambroxol-theophylline-guaiphenesin mixture) in the treatment of acute exacerbation of chronic bronchitis.

Author: YakootMostafa, SalemAmel, OmarAbdel-Mohsen

AECB treatment

This article discusses Farcosolvin, a mixture of ambroxol, theophylline, and guaiphenesin, for the treatment of acute exacerbations of chronic bronchitis (AECB).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Prulifloxacin versus levofloxacin in the treatment of severe COPD patients with acute exacerbations of chronic bronchitis.

Author: BlasiF, SchabergT, CentanniS, Del VecchioA, RosignoliM T, DionisioP

COPD treatment
Low relapse

Both prulifloxacin and levofloxacin showed efficacy rates higher than 90% in the treatment of severe COPD patients with exacerbations of chronic bronchitis, with no statistically significant differences between the two antibiotics. The long-term follow-up confirmed a very low incidence of relapse.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

24.

Chronic Cough Due to Stable Chronic Bronchitis: CHEST Expert Panel Report.

Author: MaleskerMark A, Callahan-LyonPriscilla, MadisonJ Mark, IrelandBelinda, IrwinRichard S,

CB treatment

This study reviewed research on treatments for chronic cough caused by chronic bronchitis (CB) to update previous guidelines. The goal is to provide new recommendations for managing this condition, which can significantly impact quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Effect of SGRQ-Defined Chronic Bronchitis at Baseline on Treatment Outcomes in Patients with COPD Receiving Nebulized Glycopyrrolate.

Author: TashkinDonald P, Ozol-GodfreyAyca, SharmaSanjay, SanjarShahin

Improved lung function
Improved quality of life

Chronic bronchitis, a condition that contributes to chronic obstructive pulmonary disease (COPD), can impact the effectiveness of bronchodilator medications. This study investigated the effect of nebulized glycopyrrolate, a type of bronchodilator, in patients with chronic bronchitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

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