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Cognitive and motor function after administration of hydrocodone bitartrate plus ibuprofen, ibuprofen alone, or placebo in healthy subjects with exercise-induced muscle damage: a randomized, repeated-dose, placebo-controlled study.

Author: AllenGeorge J, AndersonJeffrey M, DuffanyShannon, HartlTamara L, HoffmanJay R, KraemerWilliam J, MareshCarl M, SmithStefanie F, VanHeestJaci L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Medications combining hydrocodone bitartrate and non-steroidal anti-inflammatory agents may provide greater benefit than anti-inflammatory agents alone in treating pain and inflammation from acute soft tissue trauma, but opiate side effects such as sedation and impaired cognitive and motor performance must be considered.
Paper Details　
Original Abstract of the Article :
Medications combining hydrocodone bitartrate and non-steroidal anti-inflammatory agents appear more beneficial than anti-inflammatory medications alone in treating pain and inflammation from acute soft tissue trauma, but opiate side effects may include sedation and impaired cognitive and motor perfo...See full text at original site
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引用元：
https://doi.org/10.1007/s00213-002-1358-x

データ提供：米国国立医学図書館（NLM）

Cognitive and Motor Function After Hydrocodone Bitartrate and Ibuprofen

This study focuses on the effects of medications combining hydrocodone bitartrate (an opioid pain reliever) and ibuprofen (a nonsteroidal anti-inflammatory drug) on cognitive and motor function in healthy individuals. The researchers compared the effects of this combination, ibuprofen alone, and a placebo on individuals with exercise-induced muscle damage. The findings suggest that while this medication combination may offer pain relief, it can also have negative effects on cognitive and motor performance.

Hydrocodone Bitartrate and Ibuprofen - Potential Side Effects

The study revealed that the combination of hydrocodone bitartrate and ibuprofen was associated with sedation and impaired cognitive and motor performance. This finding emphasizes the importance of carefully weighing the potential risks and benefits of using this medication combination.

Pain Relief and Its Potential Impact

While this medication combination may provide pain relief, it's essential to be aware of the potential for sedation and impaired cognitive and motor function. Individuals using this medication should be cautious when engaging in activities that require alertness, such as driving or operating machinery. It's always important to consult with a healthcare professional to determine the most appropriate treatment plan for your individual needs.

Dr.Camel's Conclusion

Imagine a camel caravan traveling through a desert landscape. Hydrocodone bitartrate and ibuprofen can be like a powerful painkiller that helps the caravan navigate rough terrain. However, this powerful medication can also cause drowsiness and reduce alertness, potentially hindering the caravan's progress. This research highlights the delicate balance between pain relief and potential side effects, emphasizing the importance of careful consideration and monitoring when using this medication combination.
Date :
  1. Date Completed 2003-05-07
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

12552363

DOI: Digital Object Identifier

10.1007/s00213-002-1358-x

SNS
PICO Info
in preparation
Languages

English

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