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The effects of tamoxifen and toremifene on bone cells involve changes in plasma membrane ion conductance.

Author: DahllundJohanna, HärkönenPirkko L, LehenkariPetri, ParikkaVilhelmiina, RautialaTimo J, VäänänenH Kalervo, WeckströmMatti

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tamoxifen and toremifene, selective estrogen receptor modulators (SERMs), were found to cause osteoclast apoptosis in vitro. Both SERMs also had an ionophoric effect on the plasma membranes of bone cells, which may be involved in therapeutic responses and explain some clinical side effects.
Paper Details　
Original Abstract of the Article :
Selective estrogen receptor modulators (SERMs), tamoxifen (Tam) and toremifene (Tor), are widely used in the treatment of breast cancer. In addition, they have been demonstrated to prevent estrogen deficiency-induced bone loss in postmenopausal women. These effects are thought to be caused by the in...See full text at original site
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引用元：
https://doi.org/10.1359/jbmr.2003.18.3.473

データ提供：米国国立医学図書館（NLM）

Tamoxifen and Toremifene: Unraveling Their Effects on Bone Cells

Tamoxifen and toremifene, powerful medications often used to combat breast cancer, have a fascinating relationship with bone cells. Imagine these medications as skilled camel trainers, influencing the behavior of bone cells in unexpected ways. Researchers are keen to understand how these medications affect bone cell viability and function, as their impact on bone health is a critical factor in patient care. This study explores the intricate interplay between these medications and bone cells, revealing their effects on ion conductance and cell survival.

Bone Health: A Delicate Balance in the Desert of Cancer Treatment

The study reveals a complex interplay between tamoxifen, toremifene, and bone cells. These medications can influence bone cell survival, and their effects can be nuanced and dependent on various factors like concentration and the presence of estrogen. It's like navigating a desert landscape where the terrain shifts constantly – careful monitoring and individualization of treatment are paramount.

Navigating the Desert of Bone Health

This research provides valuable insights into the complex interplay between medications and bone health. Understanding the effects of tamoxifen and toremifene on bone cells is crucial for optimizing patient care and minimizing potential side effects. It's like finding a hidden oasis within the vast desert of cancer treatment, where bone health is nurtured and preserved.

Dr. Camel's Conclusion

The study unveils a remarkable aspect of tamoxifen and toremifene's impact on bone cells, reminding us that even seemingly simple medications can have complex interactions with our bodies. It's like navigating a desert with a skilled camel guide – a nuanced understanding of these interactions is crucial for providing optimal care.

Date :
  1. Date Completed 2003-10-14
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

12619932

DOI: Digital Object Identifier

10.1359/jbmr.2003.18.3.473

SNS
PICO Info
in preparation
Languages

English

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