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Ultralow-dose micronized 17beta-estradiol and bone density and bone metabolism in older women: a randomized controlled trial.

Author: KennyAnne M, KleppingerAlison, KulldorffMartin, PrestwoodKaren M

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

A dosage of 0.25 mg/d of 17beta-estradiol increased bone density of the hip, spine, and total body, and reduced bone turnover, with minimal adverse effects in older women.
Paper Details　
Original Abstract of the Article :
CONTEXT: Estrogen therapy is known to prevent osteoporosis, but studies have shown that conventional doses increase adverse events. Whether lower doses, one quarter of standard treatment, prevent bone loss is not known. OBJECTIVE: To examine the effect of 3 years of treatment with 0.25 mg/d of micr...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/12941676

データ提供：米国国立医学図書館（NLM）

Low-Dose Estrogen Therapy for Bone Health in Older Women

Estrogen therapy is well-known for its role in preventing osteoporosis, but concerns about potential side effects have led to investigations into lower-dose alternatives. This randomized controlled trial explores the impact of a low-dose (0.25 mg/d) of micronized 17beta-estradiol on bone mineral density (BMD) and bone turnover in healthy older postmenopausal women.

Low-Dose Estrogen Therapy: A Bone-Building Strategy for Older Women

The study found that low-dose estrogen therapy significantly increased BMD at all sites (hip, spine, wrist, and total body) in older women compared to placebo. This finding suggests that even at lower doses, estrogen can effectively promote bone health in older women, mitigating the risk of osteoporosis. Furthermore, markers of bone turnover, indicating bone resorption and formation, were significantly reduced in the estrogen-treated group, demonstrating a positive impact on bone metabolism.

A Balanced Approach to Estrogen Therapy

This research provides strong evidence for the efficacy of low-dose estrogen therapy in improving bone health in older women. While further research is needed to fully understand its long-term effects and potential risks, this study offers a promising approach to managing bone health in this age group.

Dr.Camel's Conclusion

This study is like a refreshing oasis in the desert, offering a safe and effective alternative to traditional high-dose estrogen therapy. Low-dose estrogen therapy holds the potential to improve bone health in older women while minimizing potential side effects.

Date :
  1. Date Completed 2003-09-02
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

12941676

DOI: Digital Object Identifier

290/8/1042

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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