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Body weight evolution during dexfenfluramine treatment after initial weight control.

Author: FinerN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A study of 45 patients who successfully completed a very low calorie diet (VLCD) compared the effects of dexfenfluramine (D-F) to placebo in maintaining weight loss. Patients receiving D-F maintained a significant weight loss (5.8 kg) over 26 weeks, while those receiving placebo gained weight (2.9 kg). After 34 weeks, the total weight loss was 21.3 kg in the D-F group compared to 11.3 kg in the placebo group. Switching patients from placebo to D-F after weight regain stabilized their weight for the next 24 weeks. The study concluded that D-F is effective in maintaining weight loss following a VLCD.
Paper Details　
Original Abstract of the Article :
While very low calorie diets (VLCD) can lead to rapid weight loss, even in patients who have often failed with conventional diets, maintaining this loss remains a clinical challenge. Since dietary re-education or more formal behaviour modification techniques are not easily applicable to large number...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1338319

データ提供：米国国立医学図書館（NLM）

Maintaining Weight Loss: The Role of Dexfenfluramine

This research delves into the challenges of weight management, specifically focusing on the role of dexfenfluramine in maintaining weight loss achieved through very low-calorie diets (VLCD). The study investigated the effectiveness of dexfenfluramine in preventing weight regain after successful VLCD completion. The researchers conducted a double-blind trial, comparing the effects of dexfenfluramine to placebo in patients who had achieved significant weight loss through VLCD. The findings revealed that dexfenfluramine was significantly more effective than placebo in maintaining weight loss over a 26-week period. This research provides valuable insights into the potential of dexfenfluramine as an adjunctive therapy for weight management after initial weight loss.

Dexfenfluramine: A Potential Ally in the Battle Against Weight Regain

The study demonstrated the effectiveness of dexfenfluramine in maintaining weight loss achieved through VLCD. Patients receiving dexfenfluramine experienced a significant reduction in weight regain compared to those receiving placebo. This finding suggests that dexfenfluramine could be a valuable tool for individuals striving to maintain long-term weight loss after achieving initial success through VLCD.

A Balanced Approach to Weight Management: Lifestyle and Medications

The study highlights the importance of a balanced approach to weight management, encompassing both lifestyle modifications and potential pharmacological interventions. While dexfenfluramine shows promise as a tool for preventing weight regain, it is essential to prioritize long-term lifestyle changes, including a healthy diet and regular exercise, to achieve sustainable weight management. The desert of weight management can be vast and challenging, but by combining lifestyle modifications and appropriate medication, we can find a path towards a healthier weight and improved well-being.

Dr.Camel's Conclusion

Weight management can feel like a long and arduous journey across a scorching desert. This study provides a refreshing oasis of hope, highlighting the potential of dexfenfluramine as a tool to help individuals maintain weight loss. However, it is important to remember that this is just one piece of the puzzle. A comprehensive approach that includes lifestyle changes, personalized support, and a collaborative partnership with healthcare professionals is essential for achieving lasting success in the desert of weight management.

Date :
  1. Date Completed 1993-04-22
  2. Date Revised 2014-06-03
Further Info :

Pubmed ID

1338319

DOI: Digital Object Identifier

1338319

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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