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Theophylline does not increase ventilatory responses to hypercapnia or hypoxia.

Author: KeensT G, PatonJ Y, SargentC W, SwaminathanS, WardS L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Theophylline, at a dose sufficient to cause side effects, did not affect chemoreceptor responsiveness.
Paper Details　
Original Abstract of the Article :
Theophylline is commonly believed to stimulate central respiratory centers. We studied the effect of oral theophylline therapy on ventilatory responses to hypercapnia and hypoxia during a double-blind placebo-controlled trial with a slow release oral theophylline preparation. We measured hypercapnic...See full text at original site
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引用元：
https://doi.org/10.1164/ajrccm/146.6.1398

データ提供：米国国立医学図書館（NLM）

Theophylline's Impact on Ventilatory Responses

The field of [respiratory medicine] is constantly seeking to understand the mechanisms underlying [respiratory function] and the effects of different medications on [ventilatory responses]. This research examines the impact of [theophylline] on [ventilatory responses] to [hypercapnia] and [hypoxia]. The study utilizes a [double-blind placebo-controlled trial] to compare the effects of [theophylline] with [placebo] in individuals with normal lung function. The findings provide valuable insights into the effects of [theophylline] on [chemoreceptor responsiveness].

Theophylline Does Not Affect Ventilatory Responses

This research demonstrates that [theophylline] does not significantly affect [ventilatory responses] to [hypercapnia] and [hypoxia]. The study found no significant differences in [ventilatory responses] between the [theophylline] and [placebo] groups. This suggests that [theophylline] does not directly stimulate [central respiratory centers] and its effects on [respiratory function] may be mediated through other mechanisms.

Understanding Medication Effects on Respiratory Function

This research highlights the importance of understanding the effects of medications on [respiratory function]. The study demonstrates that [theophylline] does not directly affect [chemoreceptor responsiveness], providing valuable insights into the potential effects of this medication on [respiratory function]. This knowledge can help healthcare providers make informed decisions about medication use, particularly in individuals with [respiratory conditions].

Dr.Camel's Conclusion

This research investigates the impact of [theophylline] on [ventilatory responses] to [hypercapnia] and [hypoxia]. The study found no significant differences in [ventilatory responses] between the [theophylline] and [placebo] groups. This suggests that [theophylline] does not directly stimulate [central respiratory centers] and its effects on [respiratory function] may be mediated through other mechanisms.

Date :
  1. Date Completed 1993-01-07
  2. Date Revised 2016-11-23
Further Info :

Pubmed ID

1456555

DOI: Digital Object Identifier

10.1164/ajrccm/146.6.1398

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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