Effects of thiamine (vitamin b1): A Synthesis of Findings from 33 Studies

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Original Abstract of the Article

Major Research Findings

Multiple studies have explored the effects of theophylline, a medication commonly used to treat asthma. Research suggests that theophylline can have both bronchodilating and anti-inflammatory effects. 30 , 18 . Despite its long history, theophylline is now considered a third-line treatment option due to the development of safer alternatives. 25 . Theophylline has been observed to affect the central nervous system, potentially impacting mood and behavior. 4 , 8 , 22 . However, studies show that theophylline might not stimulate respiratory function as initially thought. 2 .

Individual responses to theophylline can vary significantly, with some individuals being more susceptible to side effects. 4 , 8 . Theophylline’s effects can be influenced by food, with higher blood levels observed after a meal, particularly when taken in the evening. 7 . Theophylline can interact with other medications, especially calcium channel blockers, requiring careful monitoring. 6 . It's also important to be aware that theophylline can increase heart rate, which is a concern for individuals with asthma. 14 .

Benefits and Risks

Benefit Summary

Theophylline may help improve asthma symptoms by widening the airways. 15 . Additionally, theophylline may have anti-inflammatory effects, potentially reducing inflammation in the airways associated with asthma. 30 . While it has been used for many years, theophylline’s use has declined due to the development of safer alternatives. 25 .

Risk Summary

Theophylline can affect the central nervous system, potentially influencing mood and behavior. 4 , 8 , 22 . Side effects of theophylline may include gastrointestinal problems, insomnia, tremors, and an increased heart rate. 4 , 2 , 8 , 14 . Theophylline can also interact with other medications, especially calcium channel blockers, necessitating careful monitoring. 6 .

Comparing Research

Similarities in Research

A significant number of studies highlight that theophylline can widen the airways, offering a potential benefit for asthma management. 15 , 25 . Research also suggests that theophylline has anti-inflammatory properties, potentially contributing to managing asthma-related inflammation. 30 , 18 . However, a common finding across multiple studies is that theophylline can affect the central nervous system, potentially impacting mood and behavior. 4 , 8 , 22 .

Differences in Research

Individuals respond to theophylline differently, with some experiencing more side effects. 4 , 8 . Food can influence theophylline’s absorption, leading to higher blood levels, particularly when taken in the evening after a meal. 7 . Interactions with other medications, especially calcium channel blockers, can occur with theophylline. 6 . Additionally, theophylline has the potential to increase heart rate, especially for individuals with asthma. 14 .

Consistency and Contradictions in Results

While theophylline has been shown to be effective in widening the airways and potentially reducing asthma-related inflammation, 15 , 25 , 30 , 18 , its potential impact on the central nervous system and the possibility of side effects, including gastrointestinal problems, insomnia, tremors, and increased heart rate, should be acknowledged. 4 , 2 , 8 , 22 , 14 . Theophylline’s potential for drug interactions, particularly with calcium channel blockers, warrants careful monitoring. 6 .

Implications for Everyday Life

Theophylline is a medication that can be effective for managing asthma symptoms by widening the airways. 15 , 25 . However, it’s important to remember that everyone responds to medication differently, and some individuals might experience side effects. 4 , 8 . Theophylline can interact with other medications, so it’s essential to inform your doctor about all medications you are taking. 6 . It’s also crucial to follow your doctor's instructions carefully, including dosage recommendations and any food-related precautions. 7 .

Limitations of Current Research

Individual responses to theophylline can vary, and some individuals may experience more side effects. 4 , 8 . Additionally, theophylline can interact with other medications, making it important to inform your doctor about all medications you are taking. 6 .

Future Research Directions

Further research is needed to better understand individual variations in response to theophylline and to identify potential risk factors for adverse effects. 4 , 8 . Continued investigation into theophylline’s interactions with other medications is also crucial, particularly for those with other health conditions. 6 .

Conclusion

Theophylline can be a valuable option for managing asthma symptoms. 15 , 25 . However, it’s essential to be aware of the potential for side effects and interactions with other medications. 4 , 2 , 8 , 22 , 14 , 6 . Consult with your doctor to discuss the potential benefits and risks of theophylline for your specific health situation and any potential interactions with other medications you are taking.

Keywords
Benefit Keywords
Bronchodilation
1
Enhanced performance
Improved information processing
3
Improve sleep latency
Increase sleep efficiency
4
Improved memory
8
Behavior improvement
Concentration improvement
Memory improvement
9
Improved verbal learning
11
Reduced peak to trough differences
Reduced serum levels
12
Theophylline treatment
13
Bronchodilation
15
Effective bronchodilation
16
Airway function
17
Asthma treatment
18
Controls asthma symptoms
Low plasma concentration
19
Asthma treatment
22
Improved lung function
Respiratory disease treatment
23
Asthma treatment
24
Better asthma control
25
Airway function stabilisation
Bronchial responsiveness reduction
27
Anti-inflammatory
Immunomodulatory
29
COPD treatment
Reduced inflammation
30
COPD treatment
31
Asthma treatment
32
Enhanced exercise performance
33
Risk Keywords
Side effects
2
Adverse side effects
CNS stimulation
3
Individual differences
4
Side-effect awareness
5
Increased serum theophylline
6
Food effects on pharmacokinetics
7
Shaking hands
Stomach ache
8
Anxiety
Depression
9
Adenosine side effects
10
Caffeine-like symptoms
Decreased motor steadiness
Depressive symptoms
Nausea
11
Wide variations in blood levels
12
Reduced therapeutic function
Tachycardia
14
Skeletal muscle tremor
15
Side effects
17
Fall in blood monocytes
Fall in lung function
Increased asthma symptoms
19
Decreased magnesium
Decreased potassium
Increased blood pressure
Increased cholesterol
20
Affected pulmonary function
21
Behavioral problems
22
Behavioral effects
24
Gastrointestinal side effects
25
Psychological side effects
26
Tolerance
28
Adverse effects
33
Literature analysis of 33 papers
Positive Content
24
Neutral Content
1
Negative Content
8
Article Type
29
3
2
1
33
1.

[Bronchodilator effect of methylxanthine derivatives (author's transl)].

Author: WerdermannK, JordeW

Bronchodilation

Theophylline ethylenediamine and a combined methylxanthine preparation had similar bronchodilator effects at a high initial dose. At a lower long-term dose, the combined methylxanthine preparation was more effective.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

2.

Theophylline does not increase ventilatory responses to hypercapnia or hypoxia.

Author: SwaminathanS, PatonJ Y, WardS L, SargentC W, KeensT G

Side effects

Theophylline, at a dose sufficient to cause side effects, did not affect chemoreceptor responsiveness.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Effects of single and repeated doses of theophylline on aspects of performance, electrophysiology and subjective assessments in healthy human subjects.

Author: BartelP, DelportR, LotzB, UbbinkJ, BeckerP

Enhanced performance
Improved information processing
Adverse side effects
CNS stimulation

Theophylline, when taken in both single and repeated doses, was found to stimulate the central nervous system (CNS) in healthy adults. While single doses did not significantly affect mood, repeated doses led to unpleasant side effects. The study also found that tolerance to theophylline developed over four weeks of therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Effect of therapeutic plasma concentrations of theophylline on behavior, cognitive processing, and affect in children with asthma.

Author: SchlieperA, AlcockD, BeaudryP, FeldmanW, LeikinL

Improve sleep latency
Increase sleep efficiency
Individual differences

Theophylline did not significantly affect behavior, mood, or cognitive processing in children with moderate asthma, but individual differences in sensitivity were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Manufacturer's information insert and subjective theophylline side-effects.

Author: VescoD, ToumiM, FarajF, RazzoukH, OrehekJ

Side-effect awareness

The presence of a manufacturer's insert detailing side effects in theophylline packages may lead to increased reporting of side effects and decreased compliance to therapy in asthmatic patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

The influence of nifedipine and diltiazem on serum theophylline concentration-time profiles.

Author: SmithS R, HaffnerC A, KendallM J

Increased serum theophylline

Nifedipine and diltiazem have a small effect on theophylline levels in the blood. Theophylline levels may be slightly higher during nifedipine therapy, but the difference is not significant. However, this may be clinically relevant as high theophylline levels can cause side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Food effects on the nighttime pharmacokinetics of Theo-Dur tablets.

Author: KannJ, LevittM J, HorodniakJ W, PavJ W

Food effects on pharmacokinetics

Theo-Dur sustained-release theophylline tablets showed significant food effects, with higher peak serum levels and delayed absorption.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Effects of theophylline on behavior and learning in children with asthma.

Author: RappaportL, CoffmanH, GuareR, FentonT, DeGrawC, TwarogF

Improved memory
Shaking hands
Stomach ache

Theophylline had no significant effects on behavior, attention, memory, or fine motor function in children with asthma. However, parents and children reported more stomachaches and shaking hands when taking theophylline.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Cognitive and behavioral findings in children taking theophylline.

Author: FurukawaC T, DuHamelT R, WeimerL, ShapiroG G, PiersonW E, BiermanC W

Behavior improvement
Concentration improvement
Memory improvement
Anxiety
Depression

This study compared the effects of theophylline and cromolyn sodium on memory, concentration, and behavior in 29 children with asthma. The group receiving placebo theophylline/active cromolyn sodium showed greater improvement in all tests of memory and concentration. The study also raised concerns about depression and anxiety as potential long-term side effects of theophylline.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Contrasting effects of two xanthines, theophylline and enprofylline, on the cardio-respiratory stimulation of infused adenosine in man.

Author: MaxwellD L, FullerR W, ConradsonT B, DixonC M, AberV, HughesJ M, BarnesP J

Adenosine side effects

Theophylline was found to inhibit some cardio-respiratory stimulant effects of infused adenosine in humans, while enprofylline augmented these effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Extrapulmonary effects of maintenance therapy with theophylline and inhaled albuterol in patients with chronic asthma.

Author: JoadJ P, AhrensR C, LindgrenS D, WeinbergerM M

Improved verbal learning
Caffeine-like symptoms
Decreased motor steadiness
Depressive symptoms
Nausea

Theophylline was associated with a small increase in nausea and caffeine-like symptoms, while albuterol was associated with lower serum theophylline concentrations and lower neutrophil counts.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

12.

Slow release theophylline in patients with airways obstruction with particular reference to the effects of food upon serum levels.

Author: ThompsonP J, KempM W, McAllisterW A, Turner-WarwickM

Reduced peak to trough differences
Reduced serum levels
Wide variations in blood levels

Theophylline is a medication used for airways obstruction. In this study, slow-release theophylline was found to be safe and effective at a dose of 10 mg/kg/day for adults with uncomplicated airflow limitation. However, individual variability in serum levels was observed, necessitating serum monitoring for optimal use.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

[Comparison of 2 theophylline delayed-action preparations of different galenic forms].

Author: HirschH

Theophylline treatment

Two sustained-release preparations of aminophylline, Euphyllin retard and Mundiphyllin retard, are equally effective.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

14.

Effects of oral theophylline and oral salbutamol in the treatment of asthma.

Author: DawsonK P, FergussonD M

Reduced therapeutic function
Tachycardia

Theophylline and salbutamol combination at maximum oral dosage showed negative interaction, resulting in tachycardia and reduced therapeutic function in asthmatic children.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Bioavailability of theophylline from three different tablets in asthmatic patients and their bronchodilating effects in combination with terbutaline inhalation.

Author: SvedmyrK, MellstrandT, SvedmyrN

Bronchodilation
Skeletal muscle tremor

Different theophylline formulations have similar bioavailability and therapeutic effects. Theophylline alone has a moderate bronchodilating effect, but its effect is enhanced when combined with inhaled beta 2-adrenostimulants.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Bronchodilator effects of low doses of oral theophylline and terbutaline in asthmatic subjects.

Author: DeutschR I, TashkinD P, SimmonsM, CalvareseB, WangerJ, LeeY E

Effective bronchodilation

Terbutaline produced significant bronchodilatation in asthmatic subjects, while theophylline did not produce greater bronchodilatation than placebo. Theophylline did not provide additional bronchodilatation when combined with terbutaline.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

17.

Biopharmaceutic characteristics of a new extended-release theophylline formulation (Uni-Dur).

Author: OosterhuisB, BrannanM D, GroenH, PeetersP A, HempeniusJ, RadwanskiE, NomeirA A, AffrimeM B, JonkmanJ H

Airway function
Side effects

Maintaining stable plasma concentrations of theophylline is crucial for optimal airway function and minimizing adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

The effects of theophylline on mucosal inflammation in asthmatic airways: biopsy results.

Author: DjukanovićR, FinnertyJ P, LeeC, WilsonS, MaddenJ, HolgateS T

Asthma treatment

Theophylline, at doses lower than those required for bronchodilation, may contribute to asthma control by reducing suppressor/cytotoxic T-cells and cytokines involved in allergic mucosal responses.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Immunomodulation by theophylline in asthma. Demonstration by withdrawal of therapy.

Author: KidneyJ, DominguezM, TaylorP M, RoseM, ChungK F, BarnesP J

Controls asthma symptoms
Low plasma concentration
Fall in blood monocytes
Fall in lung function
Increased asthma symptoms

Theophylline withdrawal can lead to increased asthma symptoms and decreased lung function. It is associated with changes in peripheral leukocyte populations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Relationships between pharmacokinetics and nonpulmonary pharmacodynamic effects of theophylline.

Author: MintonN A, HuseyinT S, HenryJ A

Decreased magnesium
Decreased potassium
Increased blood pressure
Increased cholesterol

This study examined the relationship between theophylline concentration and its effects on various bodily functions. The results indicate that theophylline's effects on electrolyte balance and blood pressure are delayed, likely due to intracellular mechanisms.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

Decrease of histamine induced bronchoconstriction by caffeine in mild asthma.

Author: HendersonJ C, O'ConnellF, FullerR W

Affected pulmonary function

This abstract does not contain any results.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Behavioral and cognitive effect of theophylline: a dose-response study.

Author: SteinM A, LernerC A

Asthma treatment
Behavioral problems

Theophylline is a drug that is used to treat asthma. This study found that theophylline can improve behavior in children with asthma, but that these effects are short-lived and that most children experience no long-term effects on their behavior or cognitive function.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

23.

[Tolerance and effect of short-term theophylline infusions].

Author: SchmidtM

Improved lung function
Respiratory disease treatment

Theophylline and aminophylline are drugs that are used to treat respiratory problems. This study found that both drugs were effective at improving lung function, but that theophylline was more effective than aminophylline. Both drugs were well-tolerated, even when infused quickly.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

24.

Behavioral and cognitive effects of methylxanthines. A meta-analysis of theophylline and caffeine.

Author: SteinM A, KrasowskiM, LeventhalB L, PhillipsW, BenderB G

Asthma treatment
Behavioral effects

Theophylline, a treatment for asthma, has been linked to adverse behavioral and cognitive effects in children in some studies. Caffeine, another methylxanthine, has been evaluated as a potential treatment for attention-deficit hyperactivity disorder.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Salmeterol versus theophylline in the treatment of asthma.

Author: PollardS J, SpectorS L, YanceyS W, CoxF M, EmmettA

Better asthma control
Gastrointestinal side effects

Salmeterol, 42 mg twice daily, was better tolerated and significantly more effective than extended-release theophylline twice daily in the maintenance treatment of asthma. Salmeterol was more effective in improving mean morning PEF, mean predose FEV1, asthma symptoms, nighttime awakenings, and reducing the daily use of albuterol.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

26.

Neuropsychological and behavioral changes in asthmatic children treated with beclomethasone dipropionate versus theophylline.

Author: BenderB G, IkléD N, DuHamelT, TinkelmanD

Psychological side effects

The relative psychological side effects of theophylline and beclomethasone in asthmatic children need further investigation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

27.

Effect of once daily and twice daily sustained release theophylline formulations on daytime variation of bronchial hyperresponsiveness in asthmatic patients.

Author: FerrariM, OlivieriM, LamprontiG, BonazzaL, BiasinC, NacciP, TalaminiG, Lo CascioV

Airway function stabilisation
Bronchial responsiveness reduction

An ultrasustained release theophylline formulation administered once a day was more effective than a sustained release theophylline formulation administered twice a day in reducing bronchial responsiveness to methacholine in asthmatic patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

The airway effects of stopping regular oral theophylline in patients with asthma.

Author: BennettJ A, Thompson CoonJ, PavordI D, WildingP J, TattersfieldA E

Tolerance

Cessation of theophylline therapy can lead to a small rebound deterioration in lung function, consistent with the development of tolerance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

29.

Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice.

Author: LimS, JatakanonA, GordonD, MacdonaldC, ChungK F, BarnesP J

Anti-inflammatory
Immunomodulatory

Theophylline, a bronchodilator, was investigated for its effectiveness in treating asthma when added to low-dose inhaled steroids. The study found that theophylline was not as efficacious as high-dose inhaled steroids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Effect of low-dose theophylline on airway inflammation in COPD.

Author: KobayashiMotoko, NasuharaYasuyuki, BetsuyakuTomoko, ShibuyaEiji, TaninoYoshinori, TaninoMishie, TakamuraKei, NagaiKatsura, HosokawaTakeshi, NishimuraMasaharu

COPD treatment
Reduced inflammation

Theophylline treatment can attenuate neutrophil-associated inflammation in the airways of mild to moderate COPD patients. However, further studies are needed to determine the clinical benefits.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

31.

A meta-analysis on the efficacy of oral theophylline in patients with stable COPD.

Author: MolfinoNéstor A, ZhangPeter

COPD treatment

This study evaluates the efficacy of oral theophylline, a nonspecific phosphodiesterase inhibitor, in patients with clinically stable COPD. The study aimed to measure improvements in FEV1 and FVC, two indicators of lung function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

32.

Efficacy and side effects of intravenous theophylline in acute asthma: a systematic review and meta-analysis.

Author: MahemutiGulixian, ZhangHui, LiJing, TieliwaerdiNueramina, RenLili

Asthma treatment

Theophylline is a long-standing asthma treatment, but its effectiveness and side effects in different patient groups need further investigation. This meta-analysis assesses theophylline's usefulness and side effects in acute asthma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Effects of theophylline and theobromine on exercise performance and implications for competition sport: A systematic review.

Author: KennedyMichael

Enhanced exercise performance
Adverse effects

Both theophylline and theobromine, methylxanthine derivatives, have shown potential to enhance exercise performance in healthy subjects. However, more research is needed to confirm their efficacy and safety, as well as their potential to influence athletic performance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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