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Consolidation therapy with autologous bone marrow transplantation in adults with acute myeloid leukemia: a meta-analysis.

Author: BeyeneJoseph, CrumpMichael, NathanPaul C, SungLillian

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the best way to continue treatment for adults who have achieved initial remission from acute myeloid leukemia after chemotherapy, but who do not have a matching donor for a bone marrow transplant. The study compared the effectiveness of a transplant using the patient's own bone marrow (autologous transplant) to the effectiveness of non-intense chemotherapy or no further treatment.
Paper Details　
Original Abstract of the Article :
The optimal consolidation therapy for adults who are in first remission of acute myeloid leukemia after induction chemotherapy and who do not have a histocompatible donor is poorly established. We conducted a meta-analysis to compare the efficacy of autologous bone marrow transplantation with that o...See full text at original site
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引用元：
https://doi.org/10.1093/jnci/djh003

データ提供：米国国立医学図書館（NLM）

Exploring the Effectiveness of Autologous Bone Marrow Transplantation in Acute Myeloid Leukemia

The study examines the efficacy of autologous bone marrow transplantation (ABMT) as a consolidation therapy for adults in first remission of acute myeloid leukemia (AML) after induction chemotherapy. The authors conducted a meta-analysis of clinical trials comparing ABMT to non-myeloablative chemotherapy or no further treatment. Their analysis suggests that ABMT may offer a superior survival benefit compared to non-myeloablative chemotherapy alone in patients without a histocompatible donor.

The Promise of Autologous Bone Marrow Transplantation for AML

The research highlights the potential benefits of ABMT as a consolidation therapy for AML patients in first remission. The study's findings suggest that ABMT may improve survival rates compared to non-myeloablative chemotherapy alone. This information can be valuable for patients and their healthcare providers in making informed treatment decisions.

Navigating the Complexities of AML Treatment

AML is a complex and challenging cancer, requiring individualized treatment strategies. This study underscores the importance of careful consideration of different treatment options, including ABMT, to maximize outcomes. It also emphasizes the need for ongoing research to refine treatment strategies and develop new therapies for AML.

Dr. Camel's Conclusion

This research is like a camel caravan navigating the rugged terrain of AML treatment. It highlights the potential of ABMT as a valuable tool in combating this challenging disease. The journey to find effective therapies for AML is as arduous as a desert trek, requiring dedication and innovation to improve the lives of those affected by this devastating cancer.

Date :
  1. Date Completed 2004-01-27
  2. Date Revised 2019-05-13
Further Info :

Pubmed ID

14709737

DOI: Digital Object Identifier

10.1093/jnci/djh003

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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