Effective treatment of bone marrow transplantation: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Key Research Findings

Several studies indicate that bone marrow transplantation is an effective treatment option for blood disorders like leukemia. However, research has unveiled that various factors such as transplantation methods, post-transplant complications, and subsequent treatments significantly influence the success of the therapy. 10 highlights that total body irradiation, especially for adults and patients with advanced disease, is associated with lower transplant-related mortality and improved survival compared to busulfan treatment. A long-term study reported in 17 suggests that busulfan treatment is linked to a higher risk of liver veno-occlusive disease, hemorrhagic cystitis, and chronic graft-versus-host disease (GVHD) compared to total body irradiation. Additionally, busulfan treatment was associated with increased rates of chronic obstructive bronchiolitis and alopecia. 19 provides evidence that initiating Filgrastim (r-metHuG-CSF) treatment after unrelated bone marrow transplantation on day 10, instead of day 0, reduces the cost of treatment without impacting recovery or survival rates. 22 reveals that transplantation using mobilized peripheral blood progenitor cells leads to faster recovery of white blood cells and platelets compared to bone marrow transplantation but also results in a higher incidence of grade II-IV acute GVHD and chronic GVHD. These studies underscore the diverse risks and benefits associated with bone marrow transplantation, highlighting the importance of considering different transplantation methods and post-transplant treatments.

Treatment Summary

10 compared busulfan and total body irradiation as conditioning regimens, finding total body irradiation to be more effective, especially for adults and patients with advanced disease. 20 discusses the monitoring of treatment results and survival in chronic myeloid leukemia after allogeneic bone marrow transplantation (alloBMT) and the introduction of interferon alpha (IFNalpha). 18 investigates the impact of calcium supplementation with or without calcitonin on bone loss after allogeneic bone marrow transplantation. 14 compares autologous bone marrow transplantation with intensive consolidation chemotherapy for childhood acute myeloid leukemia in first remission. 5 examines the prevention of graft-versus-host disease (GVHD) through ex-vivo depletion of T lymphocytes from donor bone marrow using a monoclonal anti-T-cell antibody (CT-2) and complement. 8 explores the optimal timing of granulocyte colony-stimulating factor (G-CSF) administration after bone marrow transplantation. 3 compares chemotherapy alone with allogeneic bone marrow transplantation in children with acute myeloid leukemia in first complete remission. 27 discusses nutrition support for bone marrow transplant patients. 2 investigates the use of granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with highly malignant lymphomas and acute lymphoblastic leukemias after autologous bone marrow transplantation. 15 compares allogeneic vs autologous stem cell transplantation vs chemotherapy in patients with acute myeloid leukemia in first remission. 25 discusses nutrition support for bone marrow transplant patients. 9 compares autologous or allogeneic bone marrow transplantation with intensive chemotherapy in acute myelogenous leukemia. 22 compares the transplantation of mobilized peripheral blood cells to HLA-identical siblings with standard-risk leukemia to bone marrow transplantation. 16 examines the transplantation of bone marrow and peripheral stem cells. 28 discusses nutrition support for bone marrow transplant patients. 6 investigates high-dose bolus methylprednisolone for the treatment of acute graft versus host disease. 4 compares bone marrow transplantation or chemotherapy as post-remission treatment of adult acute myelogenous leukemia. 26 examines the impact of disease risk on the efficacy of matched related bone marrow transplantation for pediatric acute myeloid leukemia. 17 examines the long-term results of a randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow recipients with leukemia. 11 examines the use of GM-CSF as an adjunct to autologous bone marrow transplantation. 19 compares the use of Filgrastim (r-metHuG-CSF) given at different times after unrelated bone marrow transplantation. 1 examines the use of fresh and stored platelets in the treatment of bone marrow transplant recipients. 7 compares autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma. 13 compares total body irradiation-etoposide versus busulfan-cyclophosphamide as preparatory regimens for bone marrow transplantation in patients with leukemia who were not in first remission. 24 compares autologous stem cells derived from the peripheral blood compared to standard bone marrow transplant. 21 discusses nutrition support for bone marrow transplant patients. 12 examines the long-term follow-up of a phase III study of recombinant human granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for lymphoid malignancies. 23 examines consolidation therapy with autologous bone marrow transplantation in adults with acute myeloid leukemia.

Benefits and Risks

Benefits Summary

Bone marrow transplantation offers the potential to prevent disease recurrence and enhance survival rates for individuals with blood disorders like leukemia. 10 , 17 , 15 . Additionally, it can accelerate the recovery of white blood cells and platelets following transplantation. 22 , 24 .

Risks Summary

Bone marrow transplantation carries risks of complications such as GVHD, infections, liver veno-occlusive disease, hemorrhagic cystitis, and others. 10 , 17 , 22 . Furthermore, the financial burden of bone marrow transplantation can be substantial.

Comparison Across Studies

Similarities

Many studies consistently demonstrate the efficacy of bone marrow transplantation in treating blood disorders. Additionally, they consistently address the complications and risks associated with this procedure.

Differences

Variations in transplantation methods, post-transplant treatments, and patient populations across studies contribute to the differences in their findings. For instance, 10 and 17 compare busulfan and total body irradiation as pre-transplant conditioning regimens, but a definitive conclusion on which is superior remains elusive. 22 investigates both peripheral blood stem cell transplantation and bone marrow transplantation, highlighting their efficacy while noting differences in GVHD risk and recovery rates.

Consistency and Discrepancies in Findings

While bone marrow transplantation is an effective treatment option, its potential for complications is well-documented. Additionally, variations in transplantation methods and subsequent treatments influence outcomes. Therefore, it's essential to customize treatment plans based on individual patient characteristics.

Considerations for Real-Life Applications

The substantial financial cost of bone marrow transplantation can pose a significant burden. Moreover, post-transplant complications may disrupt daily life. Therefore, it's crucial for patients to engage in thorough discussions with their doctors before proceeding with bone marrow transplantation to fully comprehend the risks and benefits associated with this treatment approach.

Current Research Limitations

Many studies are limited by small sample sizes, potentially hindering the attainment of statistically significant findings. Additionally, inconsistencies in transplantation methods, post-transplant treatments, and patient populations across studies make it challenging to directly compare results.

Future Research Directions

Large-scale clinical trials are needed to further investigate the safety and efficacy of bone marrow transplantation. Optimizing transplantation methods and post-transplant treatments holds the potential to mitigate complications and enhance treatment success rates.

Conclusion

Bone marrow transplantation presents a viable treatment option for blood disorders like leukemia, but it's important to acknowledge the associated risks of complications. Individualized treatment plans are crucial, carefully considering the specific needs and characteristics of each patient. This information empowers patients to make informed decisions about their health and treatment options.

Treatment List

Busulfan, Total Body Irradiation, Interferon Alpha, Calcium, Calcitonin, Autologous Bone Marrow Transplantation, Intensive Consolidation Chemotherapy, Monoclonal Anti-T-cell Antibody, Complement, G-CSF, Filgrastim (r-metHuG-CSF), Peripheral Blood Stem Cell Transplantation, High-Dose Methylprednisolone, Salvage Chemotherapy, rhGM-CSF

Keywords
Benefit Keywords
Bone marrow transplant
1
GM-CSF treatment
Neutrophil regeneration
Thrombocyte improvement
2
AML treatment
3
AML treatment
4
Graft-versus-host disease reduction
Leukemia relapse reduction
5
GvHD treatment
6
Increased event-free survival
Increased survival
7
Hastens myeloid recovery
8
Leukemia treatment
9
Leukemia treatment
10
Improved Hodgkin's disease treatment
11
Effective treatment
Long-term safety
12
Improved survival in leukemia patients
13
AML treatment
14
Improved AML treatment
15
Improved bone marrow transplantation treatment
16
Leukemia treatment
17
Effective treatment
Reduced costs
19
Longer survival
20
Prevention of malnutrition
21
Faster neutrophil recovery
Faster platelet recovery
Hematopoiesis restoration
22
Peripheral blood stem cell transplantation
24
Improved bone marrow transplant treatment
25
Improved acute myeloid leukemia treatment
26
Improved bone marrow transplant treatment
27
Bone marrow transplant treatment
28
Risk Keywords
None mentioned
1
Mild side effects
2
Toxicity
3
Graft failure
5
Hyperglycemia
Steroid gastritis
6
Toxic effects
7
Hematopoietic recovery delay
Transplantation mortality
9
Graft-versus-host disease
Hemorrhagic cystitis
Liver toxicity
Seizures
10
Graft-versus-host disease
Leukemic relapse
13
Relapse
Treatment related mortality
14
Cataracts
16
Alopecia
Cataracts
Graft-versus-host disease
Hemorrhagic cystitis
Obstructive bronchiolitis
Veno-occlusive disease
17
Bone loss
Fracture risk
Hypogonadism
18
Increased infection risk
21
Acute graft versus host disease
Chronic graft versus host disease
22
High dose chemotherapy
Lymphoma
24
Bone marrow transplantation
25
Acute myeloid leukemia
26
Bone marrow transplantation
27
Literature analysis of 28 papers
Positive Content
26
Neutral Content
1
Negative Content
1
Article Type
20
6
5
6
28
1.

A randomized trial comparing the use of fresh and stored platelets in the treatment of bone marrow transplant recipients.

Author: ShanwellA, LarssonS, AschanJ, RingdénO

Bone marrow transplant
None mentioned

A study of 39 patients undergoing bone marrow transplantation compared the effectiveness of using fresh versus stored single-donor platelet concentrates (PC). The study found no significant difference in the total platelet requirement, platelet count increase at 1 hour, or platelet count increase at 18 hours between the groups. The study concluded that there is no major difference in effectiveness between fresh and stored single-donor platelets.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Granulocyte-macrophage colony-stimulating factor. Treatment of patients with highly malignant lymphomas and acute lymphoblastic leukemias after autologous bone marrow transplantation].

Author: JessenP, NielsenB, JensenI M, EllegaardJ, HoklandP

GM-CSF treatment
Neutrophil regeneration
Thrombocyte improvement
Mild side effects

A study of 10 patients who received a bone marrow transplant after high-dose radiation and chemotherapy found that treatment with granulocyte-macrophage colony-stimulating factor (GM-CSF) led to faster recovery of white blood cells and a lower need for blood transfusions compared to a historical control group. GM-CSF treatment also significantly improved platelet levels. While GM-CSF treatment was associated with mild side effects in some patients, there was no significant difference in the incidence of severe complications, infections, or hospital stays between the groups. The study concludes that GM-CSF treatment is beneficial for patients undergoing bone marrow transplantation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Danish

3.

[Comparison of chemotherapy alone with allogeneic bone marrow transplantation in first full remission in children with acute myeloid leukemia in the AML-BFM-83 and AML-BFM-87 studies--matched pair analysis].

Author: CreutzigU, Bender-GötzeC, KlingebielT, EbellW, FriedrichW, Stollmann-GibbelsB, SchmidtH, SuttorpM, GratwohlA, HeyenP

AML treatment
Toxicity

A study of 16 patients with acute myeloid leukemia (AML) compared the outcomes of allogeneic bone marrow transplantation (BMT) to standard chemotherapy (CT-MC). Both treatments resulted in similar outcomes, with comparable rates of relapse and treatment-related deaths. The 9-year event-free survival rate was similar for both groups (73% for BMT and 67% for CT-MC). However, BMT was associated with more side effects, including long-term complications. The study concluded that there was no significant advantage to BMT for patients in their first complete remission. The study recommends that only high-risk patients receive BMT as soon as possible after achieving remission.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

4.

Bone marrow transplantation or chemotherapy as post-remission treatment of adult acute myelogenous leukemia.

Author: WillemzeR, FibbeW E, Kluin-NelemansJ C, FalkenburgJ H, RichelD J, PetersW G, den OttolanderG J, BrandA, ZwaanF E

AML treatment

This study compared three treatment approaches for patients with acute myeloid leukemia (AML) in remission: intensive consolidation chemotherapy (SIC), autologous bone marrow transplant (auto-BMT), and allogeneic bone marrow transplant (allo-BMT). While the study found that allo-BMT had the lowest relapse rate (35%) compared to SIC (80%) and auto-BMT (50%), there was no significant difference in overall disease-free survival between the groups. The study suggests that while bone marrow transplants may offer potential benefits, more extensive research is needed to definitively assess the effectiveness of these treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of graft-versus-host disease. A prospective, randomized, double-blind trial.

Author: MitsuyasuR T, ChamplinR E, GaleR P, HoW G, LenarskyC, WinstonD, SelchM, ElashoffR, GiorgiJ V, WellsJ

Graft-versus-host disease reduction
Leukemia relapse reduction
Graft failure

This study investigated the effects of removing T cells from donor bone marrow before transplantation in 40 patients with leukemia. The study found that removing T cells significantly reduced the incidence of graft-versus-host disease (GVHD), a serious complication of bone marrow transplantation. However, it also increased the risk of graft failure. While relapse rates were similar, the study found evidence of leukemia in those who experienced graft failure. The study concludes that removing T cells from donor bone marrow may reduce GVHD, but further research is needed to determine the long-term effects on graft success and cancer recurrence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

High dose bolus methylprednisolone for the treatment of acute graft versus host disease.

Author: BacigalupoA, van LintM T, FrassoniF, Podesta'M, VenezianoG, AvanziG, VitaleV, MarmontA M

GvHD treatment
Hyperglycemia
Steroid gastritis

High-dose methylprednisolone (BMPr) was effective in treating acute graft-versus-host disease (GvHD) in HLA-matched bone marrow transplant recipients, with a 43% complete response rate and an additional 50% partial response. However, BMPr was ineffective in HLA-mismatched recipients. Common side effects included hyperglycemia and steroid-associated gastritis, which responded well to conventional treatment. BMPr appears to be a safe and effective treatment for acute GvHD in HLA-matched recipients, but further research is needed to explore its efficacy in HLA-mismatched recipients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma.

Author: PhilipT, GuglielmiC, HagenbeekA, SomersR, Van der LelieH, BronD, SonneveldP, GisselbrechtC, CahnJ Y, HarousseauJ L

Increased event-free survival
Increased survival
Toxic effects

High-dose chemotherapy and autologous bone marrow transplantation increased event-free and overall survival in patients with chemotherapy-sensitive non-Hodgkin's lymphoma in relapse.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Optimal timing of granulocyte colony-stimulating factor (G-CSF) administration after bone marrow transplantation. A prospective randomized study.

Author: Torres GómezA, JimenezM A, AlvarezM A, RodriguezA, MartinC, GarciaM J, FloresR, SanchezJ, de la TorreM J, HerreraC

Hastens myeloid recovery

This study of 75 patients undergoing allogeneic or autologous bone marrow transplantation found that there was no significant difference in the time to reach neutrophil and platelet recovery between patients who started G-CSF on day 0 and those who started on day +7. However, starting G-CSF on day +7 was associated with significant cost savings.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) Leukemia Cooperative Groups.

Author: ZittounR A, MandelliF, WillemzeR, de WitteT, LabarB, ResegottiL, LeoniF, DamasioE, VisaniG, PapaG

Leukemia treatment
Hematopoietic recovery delay
Transplantation mortality

Autologous and allogeneic bone marrow transplantation resulted in better disease-free survival than intensive consolidation chemotherapy for acute myelogenous leukemia in first complete remission.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

A randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia: a report from the Nordic Bone Marrow Transplantation Group.

Author: RingdénO, RuutuT, RembergerM, NikoskelainenJ, VolinL, VindeløvL, ParkkaliT, LenhoffS, SallerforsB, LjungmanP

Leukemia treatment
Graft-versus-host disease
Hemorrhagic cystitis
Liver toxicity
Seizures

This study of 167 patients with leukemia receiving marrow transplants found that patients treated with busulfan had a higher incidence of veno-occlusive disease of the liver, hemorrhagic cystitis, and transplant-related mortality compared to those treated with total body irradiation (TBI).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

GM-CSF as an adjunct to autologous bone marrow transplantation.

Author: GulatiS, BennettC, PhillipsJ, Van-PoznakC

Improved Hodgkin's disease treatment

The study found that using GM-CSF after autologous bone marrow transplantation (AuBMT) for Hodgkin's disease speeds up recovery of blood cells and is cost-effective. The study highlights the benefits of using growth factors like GM-CSF in intensive cancer treatment, particularly for patients with relapsed Hodgkin's disease undergoing chemotherapy and AuBMT. Further research is needed to optimize the use of growth factors in cancer treatment, including the timing and duration of administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Long-term follow-up of a phase III study of recombinant human granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for lymphoid malignancies.

Author: RabinoweS N, NeubergD, BiermanP J, VoseJ M, NemunaitisJ, SingerJ W, FreedmanA S, MauchP, DemetriG, OnettoN

Effective treatment
Long-term safety

rhGM-CSF showed no apparent long-term adverse effects on bone marrow function after autologous bone marrow transplantation (ABMT) for non-Hodgkin's lymphoma, Hodgkin's disease, and acute lymphoblastic leukemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

13.

A prospective randomized comparison of total body irradiation-etoposide versus busulfan-cyclophosphamide as preparatory regimens for bone marrow transplantation in patients with leukemia who were not in first remission: a Southwest Oncology Group study.

Author: BlumeK G, KopeckyK J, Henslee-DowneyJ P, FormanS J, StiffP J, LeMaistreC F, AppelbaumF R

Improved survival in leukemia patients
Graft-versus-host disease
Leukemic relapse

This phase III trial of 122 patients with leukemia undergoing allogeneic bone marrow transplantation found that fractionated total body irradiation and etoposide (FTBI/VP-16) and high-dose busulfan with cyclophosphamide (BU/CY) regimens were associated with similar overall survival and disease-free survival rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. Pediatric Oncology Group.

Author: RavindranathY, YeagerA M, ChangM N, SteuberC P, KrischerJ, Graham-PoleJ, CarrollA, InoueS, CamittaB, WeinsteinH J

AML treatment
Relapse
Treatment related mortality

Treatment of children with AML in first remission with either autologous bone marrow transplantation or intensive chemotherapy prolongs event-free survival equally.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

15.

Allogeneic vs autologous stem cell transplantation vs chemotherapy in patients with acute myeloid leukemia in first remission: the BGMT 87 study.

Author: ReiffersJ, StoppaA M, AttalM, MichalletM, MaritG, BlaiseD, HuguetF, CorrontB, Cony-MakhoulP, GastautJ A, LaurentG, MolinaL, BroustetA, MaraninchiD, PrisJ, HollardD, FaberesC

Improved AML treatment

In a study of 204 people with acute myeloid leukemia (AML), 79.4% achieved complete remission. For those under 46 with a suitable donor, allogeneic bone marrow transplant (alloBMT) resulted in a higher 3-year disease-free survival rate (66.5%) compared to those who did not have a suitable donor and received either autologous stem cell transplant (ASCT) or chemotherapy (42.4%). AlloBMT was also associated with a lower relapse rate. For patients without a suitable donor, there was no significant difference in outcomes between ASCT and chemotherapy. These findings suggest that alloBMT may be the most effective treatment option for eligible patients with AML.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group.

Author: RingdénO, RembergerM, RuutuT, NikoskelainenJ, VolinL, VindeløvL, ParkkaliT, LenhoffS, SallerforsB, MellanderL, LjungmanP, JacobsenN

Leukemia treatment
Alopecia
Cataracts
Graft-versus-host disease
Hemorrhagic cystitis
Obstructive bronchiolitis
Veno-occlusive disease

This study compared the effects of busulfan and total body irradiation (TBI) as conditioning regimens for bone marrow transplantation in leukemic patients. Busulfan was associated with a higher risk of veno-occlusive disease of the liver, hemorrhagic cystitis, and chronic graft-versus-host disease, while TBI was associated with a higher risk of obstructive bronchiolitis and cataracts.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

A prospective study of bone loss and turnover after allogeneic bone marrow transplantation: effect of calcium supplementation with or without calcitonin.

Author: VälimäkiM J, KinnunenK, VolinL, TähteläR, LöyttyniemiE, LaitinenK, MäkeläP, KetoP, RuutuT

Bone loss
Fracture risk
Hypogonadism

This study investigated bone loss after allogeneic bone marrow transplantation (BMT) and the potential benefits of calcium and calcitonin in preventing bone loss. The study found that significant bone loss occurs after BMT and that calcium with or without calcitonin does not prevent it.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

A prospective randomized trial of Filgrastim (r-metHuG-CSF) given at different times after unrelated bone marrow transplantation.

Author: HägglundH, RingdénO, OmanS, RembergerM, CarlensS, MattssonJ

Effective treatment
Reduced costs

A study comparing three different timing regimens for Filgrastim (r-metHuG-CSF) after unrelated bone marrow transplantation (BMT) found no significant differences in hematological recovery, complications, or survival. Starting Filgrastim treatment later (day +10) reduced costs without affecting recovery time.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Monitoring treatment and survival in chronic myeloid leukemia. Italian Cooperative Study Group on Chronic Myeloid Leukemia and Italian Group for Bone Marrow Transplantation.

Author:

Longer survival

Allogeneic bone marrow transplantation (alloBMT) was associated with significantly longer survival compared to conventional chemotherapy in patients with chronic myeloid leukemia, regardless of age or risk.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Nutrition support for bone marrow transplant patients.

Author: MurrayS M, PindoriaS

Prevention of malnutrition
Increased infection risk

Bone marrow transplant involves strong medications and the infusion of bone marrow cells. These treatments can cause problems like loss of appetite, mouth sores, and digestive problems, leading to malnutrition. While feeding through a vein (parenteral nutrition) is commonly used, it can increase the risk of infection. Feeding through a tube into the stomach (enteral nutrition) is an alternative, and adding substances like glutamine to feeding solutions is also being studied. However, more research is needed to determine the best way to provide nutrition after bone marrow transplantation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Transplantation of mobilized peripheral blood cells to HLA-identical siblings with standard-risk leukemia.

Author: SchmitzNorbert, BeksacMeral, HasencleverDirk, BacigalupoAndrea, RuutuTapani, NaglerArnon, GluckmanEliane, RussellNigel, ApperleyJane F, GorinNorbert C, SzerJeff, BradstockKen, BuzynAgnes, ClarkPeter, BorkettKeith, GratwohlAlois,

Faster neutrophil recovery
Faster platelet recovery
Hematopoiesis restoration
Acute graft versus host disease
Chronic graft versus host disease

The study compares the use of allogeneic mobilized peripheral blood progenitor cells to bone marrow transplantation for restoring hematopoiesis after myeloablative therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Consolidation therapy with autologous bone marrow transplantation in adults with acute myeloid leukemia: a meta-analysis.

Author: NathanPaul C, SungLillian, CrumpMichael, BeyeneJoseph

This study investigated the best way to continue treatment for adults who have achieved initial remission from acute myeloid leukemia after chemotherapy, but who do not have a matching donor for a bone marrow transplant. The study compared the effectiveness of a transplant using the patient's own bone marrow (autologous transplant) to the effectiveness of non-intense chemotherapy or no further treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Autologous stem cells derived from the peripheral blood compared to standard bone marrow transplant; time to engraftment: a systematic review.

Author: LewisAlly

Peripheral blood stem cell transplantation
High dose chemotherapy
Lymphoma

This review evaluates the evidence for using peripheral blood stem cell transplantation compared to standard bone marrow transplantation in lymphoma patients undergoing high-dose chemotherapy, highlighting the potential benefits of peripheral blood stem cells.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Nutrition support for bone marrow transplant patients.

Author: MurraySusan M, PindoriaSima

Improved bone marrow transplant treatment
Bone marrow transplantation

Bone marrow transplantation involves strong chemotherapy and the infusion of bone marrow cells. After treatment, many patients experience poor appetite, mouth sores, and digestive problems, leading to malnutrition. While intravenous feeding is often used, it increases the risk of infection. Feeding through a tube into the stomach (enteral nutrition) is an alternative, as is adding specific nutrients to the feeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Impact of disease risk on efficacy of matched related bone marrow transplantation for pediatric acute myeloid leukemia: the Children's Oncology Group.

Author: HoranJohn T, AlonzoTodd A, LymanGary H, GerbingRobert B, LangeBeverly J, RavindranathYaddanapudi, BectonDavid, SmithFranklin O, WoodsWilliam G,

Improved acute myeloid leukemia treatment
Acute myeloid leukemia

There is variation in the use of bone marrow transplantation from a matching relative for children newly diagnosed with acute myeloid leukemia (AML). Some doctors believe it should be offered to most children who achieve remission, while others think it should be reserved for high-risk cases. This study examines how the risk of the disease affects the effectiveness of bone marrow transplantation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

27.

Nutrition support for bone marrow transplant patients.

Author: MurraySusan M, PindoriaSima

Improved bone marrow transplant treatment
Bone marrow transplantation

Bone marrow transplantation involves strong chemotherapy and the infusion of bone marrow cells. After treatment, many patients experience poor appetite, mouth sores, and digestive problems, leading to malnutrition. While intravenous feeding is often used, it increases the risk of infection. Feeding through a tube into the stomach (enteral nutrition) is an alternative, as is adding specific nutrients to the feeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

WITHDRAWN: Nutrition support for bone marrow transplant patients.

Author: MurraySusan M, PindoriaSima

Bone marrow transplant treatment

Bone marrow transplantation involves strong chemotherapy and the infusion of new bone marrow cells. After treatment, patients often have problems eating, leading to malnutrition. While intravenous nutrition (PN) is often used, it increases infection risk. Enteral nutrition (EN) and nutritional supplements are potential alternatives. This review updates previous research on this topic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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