Effective treatment of c. diff infections: A Synthesis of Findings from 28 Studies

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Original Abstract of the Article

Major Research Findings

Several studies have investigated bone loss and bone turnover after allogeneic bone marrow transplantation (BMT). These studies have shown that significant bone loss occurs after BMT, and that this loss is caused by an imbalance between reduced bone formation and increased bone resorption. 18 Additionally, hypogonadism may be a contributing factor to bone loss in men after BMT. 18 However, calcium supplementation with or without calcitonin did not prevent bone loss or improve bone metabolism. 18

In the treatment of acute myelogenous leukemia (AML), bone marrow transplantation has been shown to be more effective than chemotherapy. Specifically, allogeneic bone marrow transplantation from an HLA-matched donor has been found to result in higher disease-free survival rates than autologous transplantation or chemotherapy. 9 15

In pediatric AML, autologous bone marrow transplantation did not show a clear advantage over intensive consolidation chemotherapy. 14

High-dose bolus methylprednisolone has been shown to be an effective treatment for established acute graft-versus-host disease (GvHD) after BMT. However, its effectiveness in recipients of HLA-mismatched grafts is less clear. 6

Granulocyte colony-stimulating factor (G-CSF) is used to accelerate hematopoietic recovery after BMT. The timing of G-CSF administration (day 0, day +5, or day +10 after BMT) did not significantly affect hematopoietic recovery. 19 Furthermore, starting G-CSF administration on day +7 post-BMT can reduce the consumption of G-CSF. 8

Two conditioning regimens for BMT in patients with leukemia who were not in first remission have been shown to be effective: fractionated total body irradiation (FTBI) and etoposide (FTBI/VP-16), or high-dose busulfan and cyclophosphamide (BU/CY). These regimens did not differ significantly in terms of overall survival or disease-free survival. 13

The combination of cyclosporine and prednisone has been shown to be effective in preventing GvHD after BMT. 13

There was no significant difference in effectiveness between fresh and stored single donor platelet concentrates in BMT recipients. 1

Peripheral blood stem cell transplantation has been shown to be more effective than bone marrow transplantation in terms of neutrophil and platelet recovery in lymphoma patients who require high-dose chemotherapy. 24

Nutrition management after BMT is crucial. Enteral nutrition is recommended over parenteral nutrition due to its lower infection risk. 28 27 21

Treatment Summary

Calcium supplementation with or without calcitonin has been shown to be ineffective in preventing bone loss after BMT. 18 In the treatment of AML, allogeneic bone marrow transplantation is more effective than autologous transplantation or chemotherapy. 9 15 High-dose bolus methylprednisolone is an effective treatment for established acute GvHD. 6 G-CSF is used to accelerate hematopoietic recovery after BMT. 19 Two effective conditioning regimens for BMT include FTBI/VP-16 and BU/CY. 13 The combination of cyclosporine and prednisone is effective in preventing GvHD. 13 Peripheral blood stem cell transplantation is more effective than bone marrow transplantation in terms of neutrophil and platelet recovery in lymphoma patients. 24 After BMT, enteral nutrition is recommended for nutritional management. 28 27 21

Benefits and Risks

Benefit Summary

Bone marrow transplantation is an effective treatment for hematological malignancies such as AML and lymphoma. 9 15 24 Allogeneic bone marrow transplantation from an HLA-matched donor has been found to result in higher disease-free survival rates than autologous transplantation or chemotherapy. 9 15 G-CSF effectively accelerates hematopoietic recovery after BMT. 19 Enteral nutrition is recommended for nutritional management after BMT due to its lower infection risk compared to parenteral nutrition. 28 27 21

Risk Summary

Bone marrow transplantation carries risks, including GvHD, infections, bleeding, and organ damage. 13 Busulfan can increase the risk of hepatic veno-occlusive disease and hemorrhagic cystitis. 10 Total body irradiation can increase the risk of cataracts. 10

Comparison of Studies

Commonalities of Studies

Multiple studies have shown that bone loss after BMT is caused by reduced bone formation and increased bone resorption. 18 Several studies have also indicated that G-CSF is effective in accelerating hematopoietic recovery after BMT. 19 8 The importance of nutritional management after BMT has been emphasized in numerous studies. 28 27 21

Differences in Studies

The effectiveness of autologous bone marrow transplantation in treating AML has shown variability across studies. One study found no significant difference between autologous transplantation and chemotherapy. 14 However, other studies demonstrated that autologous transplantation was more effective than chemotherapy. 9 15 Different conditioning regimens for BMT have also been studied, and effective regimens vary across studies. 13 10

Consistency and Contradictions of Results

While bone marrow transplantation has been shown to be an effective treatment for hematological malignancies, the effectiveness of autologous BMT in treating AML remains inconsistent across studies. Further research is required to clarify this aspect.

Practical Applications and Considerations

Bone marrow transplantation is a valuable treatment option for hematological malignancies, but it carries risks. Treatment should be carefully tailored to each patient's individual needs. Effective nutritional management after BMT is essential, and patients should follow the guidance of their physicians and nurses regarding their nutritional intake.

Limitations of Current Research

There are several limitations in bone marrow transplantation research. For example, some studies involve small patient populations, and different treatment approaches may be used across studies. It's essential to consider these limitations when interpreting research findings.

Future Research Directions

Future bone marrow transplantation research should include large-scale clinical trials with more patients and standardized treatment methods. Research focusing on the development of new treatments, as well as the prevention and treatment of complications after BMT, is also crucial.

Conclusion

Bone marrow transplantation has been shown to be an effective treatment for hematological malignancies, but it involves risks. Treatment should be personalized and carefully considered for each patient. Future research aims to develop safer and more effective treatments for these diseases.

Treatment List

Calcium, calcitonin, chemotherapy, bone marrow transplantation, allogeneic bone marrow transplantation, autologous bone marrow transplantation, peripheral blood stem cell transplantation, G-CSF, high-dose bolus methylprednisolone, cyclosporine, prednisone, total body irradiation, busulfan, cyclophosphamide, etoposide, enteral nutrition, parenteral nutrition

Keywords
Benefit Keywords
Bone marrow transplant
1
GM-CSF treatment
Neutrophil regeneration
Thrombocyte improvement
2
AML treatment
3
AML treatment
4
Graft-versus-host disease reduction
Leukemia relapse reduction
5
GvHD treatment
6
Increased event-free survival
Increased survival
7
Hastens myeloid recovery
8
Leukemia treatment
9
Leukemia treatment
10
Improved Hodgkin's disease treatment
11
Effective treatment
Long-term safety
12
Improved survival in leukemia patients
13
AML treatment
14
Improved AML treatment
15
Improved bone marrow transplantation treatment
16
Leukemia treatment
17
Effective treatment
Reduced costs
19
Longer survival
20
Prevention of malnutrition
21
Faster neutrophil recovery
Faster platelet recovery
Hematopoiesis restoration
22
Peripheral blood stem cell transplantation
24
Improved bone marrow transplant treatment
25
Improved acute myeloid leukemia treatment
26
Improved bone marrow transplant treatment
27
Bone marrow transplant treatment
28
Risk Keywords
None mentioned
1
Mild side effects
2
Toxicity
3
Graft failure
5
Hyperglycemia
Steroid gastritis
6
Toxic effects
7
Hematopoietic recovery delay
Transplantation mortality
9
Graft-versus-host disease
Hemorrhagic cystitis
Liver toxicity
Seizures
10
Graft-versus-host disease
Leukemic relapse
13
Relapse
Treatment related mortality
14
Cataracts
16
Alopecia
Cataracts
Graft-versus-host disease
Hemorrhagic cystitis
Obstructive bronchiolitis
Veno-occlusive disease
17
Bone loss
Fracture risk
Hypogonadism
18
Increased infection risk
21
Acute graft versus host disease
Chronic graft versus host disease
22
High dose chemotherapy
Lymphoma
24
Bone marrow transplantation
25
Acute myeloid leukemia
26
Bone marrow transplantation
27
Literature analysis of 28 papers
Positive Content
26
Neutral Content
1
Negative Content
1
Article Type
20
6
5
6
28
1.

A randomized trial comparing the use of fresh and stored platelets in the treatment of bone marrow transplant recipients.

Author: ShanwellA, LarssonS, AschanJ, RingdénO

Bone marrow transplant
None mentioned

A study of 39 patients undergoing bone marrow transplantation compared the effectiveness of using fresh versus stored single-donor platelet concentrates (PC). The study found no significant difference in the total platelet requirement, platelet count increase at 1 hour, or platelet count increase at 18 hours between the groups. The study concluded that there is no major difference in effectiveness between fresh and stored single-donor platelets.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

[Granulocyte-macrophage colony-stimulating factor. Treatment of patients with highly malignant lymphomas and acute lymphoblastic leukemias after autologous bone marrow transplantation].

Author: JessenP, NielsenB, JensenI M, EllegaardJ, HoklandP

GM-CSF treatment
Neutrophil regeneration
Thrombocyte improvement
Mild side effects

A study of 10 patients who received a bone marrow transplant after high-dose radiation and chemotherapy found that treatment with granulocyte-macrophage colony-stimulating factor (GM-CSF) led to faster recovery of white blood cells and a lower need for blood transfusions compared to a historical control group. GM-CSF treatment also significantly improved platelet levels. While GM-CSF treatment was associated with mild side effects in some patients, there was no significant difference in the incidence of severe complications, infections, or hospital stays between the groups. The study concludes that GM-CSF treatment is beneficial for patients undergoing bone marrow transplantation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Danish

3.

[Comparison of chemotherapy alone with allogeneic bone marrow transplantation in first full remission in children with acute myeloid leukemia in the AML-BFM-83 and AML-BFM-87 studies--matched pair analysis].

Author: CreutzigU, Bender-GötzeC, KlingebielT, EbellW, FriedrichW, Stollmann-GibbelsB, SchmidtH, SuttorpM, GratwohlA, HeyenP

AML treatment
Toxicity

A study of 16 patients with acute myeloid leukemia (AML) compared the outcomes of allogeneic bone marrow transplantation (BMT) to standard chemotherapy (CT-MC). Both treatments resulted in similar outcomes, with comparable rates of relapse and treatment-related deaths. The 9-year event-free survival rate was similar for both groups (73% for BMT and 67% for CT-MC). However, BMT was associated with more side effects, including long-term complications. The study concluded that there was no significant advantage to BMT for patients in their first complete remission. The study recommends that only high-risk patients receive BMT as soon as possible after achieving remission.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

4.

Bone marrow transplantation or chemotherapy as post-remission treatment of adult acute myelogenous leukemia.

Author: WillemzeR, FibbeW E, Kluin-NelemansJ C, FalkenburgJ H, RichelD J, PetersW G, den OttolanderG J, BrandA, ZwaanF E

AML treatment

This study compared three treatment approaches for patients with acute myeloid leukemia (AML) in remission: intensive consolidation chemotherapy (SIC), autologous bone marrow transplant (auto-BMT), and allogeneic bone marrow transplant (allo-BMT). While the study found that allo-BMT had the lowest relapse rate (35%) compared to SIC (80%) and auto-BMT (50%), there was no significant difference in overall disease-free survival between the groups. The study suggests that while bone marrow transplants may offer potential benefits, more extensive research is needed to definitively assess the effectiveness of these treatments.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Treatment of donor bone marrow with monoclonal anti-T-cell antibody and complement for the prevention of graft-versus-host disease. A prospective, randomized, double-blind trial.

Author: MitsuyasuR T, ChamplinR E, GaleR P, HoW G, LenarskyC, WinstonD, SelchM, ElashoffR, GiorgiJ V, WellsJ

Graft-versus-host disease reduction
Leukemia relapse reduction
Graft failure

This study investigated the effects of removing T cells from donor bone marrow before transplantation in 40 patients with leukemia. The study found that removing T cells significantly reduced the incidence of graft-versus-host disease (GVHD), a serious complication of bone marrow transplantation. However, it also increased the risk of graft failure. While relapse rates were similar, the study found evidence of leukemia in those who experienced graft failure. The study concludes that removing T cells from donor bone marrow may reduce GVHD, but further research is needed to determine the long-term effects on graft success and cancer recurrence.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

6.

High dose bolus methylprednisolone for the treatment of acute graft versus host disease.

Author: BacigalupoA, van LintM T, FrassoniF, Podesta'M, VenezianoG, AvanziG, VitaleV, MarmontA M

GvHD treatment
Hyperglycemia
Steroid gastritis

High-dose methylprednisolone (BMPr) was effective in treating acute graft-versus-host disease (GvHD) in HLA-matched bone marrow transplant recipients, with a 43% complete response rate and an additional 50% partial response. However, BMPr was ineffective in HLA-mismatched recipients. Common side effects included hyperglycemia and steroid-associated gastritis, which responded well to conventional treatment. BMPr appears to be a safe and effective treatment for acute GvHD in HLA-matched recipients, but further research is needed to explore its efficacy in HLA-mismatched recipients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin's lymphoma.

Author: PhilipT, GuglielmiC, HagenbeekA, SomersR, Van der LelieH, BronD, SonneveldP, GisselbrechtC, CahnJ Y, HarousseauJ L

Increased event-free survival
Increased survival
Toxic effects

High-dose chemotherapy and autologous bone marrow transplantation increased event-free and overall survival in patients with chemotherapy-sensitive non-Hodgkin's lymphoma in relapse.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Optimal timing of granulocyte colony-stimulating factor (G-CSF) administration after bone marrow transplantation. A prospective randomized study.

Author: Torres GómezA, JimenezM A, AlvarezM A, RodriguezA, MartinC, GarciaM J, FloresR, SanchezJ, de la TorreM J, HerreraC

Hastens myeloid recovery

This study of 75 patients undergoing allogeneic or autologous bone marrow transplantation found that there was no significant difference in the time to reach neutrophil and platelet recovery between patients who started G-CSF on day 0 and those who started on day +7. However, starting G-CSF on day +7 was associated with significant cost savings.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) Leukemia Cooperative Groups.

Author: ZittounR A, MandelliF, WillemzeR, de WitteT, LabarB, ResegottiL, LeoniF, DamasioE, VisaniG, PapaG

Leukemia treatment
Hematopoietic recovery delay
Transplantation mortality

Autologous and allogeneic bone marrow transplantation resulted in better disease-free survival than intensive consolidation chemotherapy for acute myelogenous leukemia in first complete remission.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

A randomized trial comparing busulfan with total body irradiation as conditioning in allogeneic marrow transplant recipients with leukemia: a report from the Nordic Bone Marrow Transplantation Group.

Author: RingdénO, RuutuT, RembergerM, NikoskelainenJ, VolinL, VindeløvL, ParkkaliT, LenhoffS, SallerforsB, LjungmanP

Leukemia treatment
Graft-versus-host disease
Hemorrhagic cystitis
Liver toxicity
Seizures

This study of 167 patients with leukemia receiving marrow transplants found that patients treated with busulfan had a higher incidence of veno-occlusive disease of the liver, hemorrhagic cystitis, and transplant-related mortality compared to those treated with total body irradiation (TBI).

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

GM-CSF as an adjunct to autologous bone marrow transplantation.

Author: GulatiS, BennettC, PhillipsJ, Van-PoznakC

Improved Hodgkin's disease treatment

The study found that using GM-CSF after autologous bone marrow transplantation (AuBMT) for Hodgkin's disease speeds up recovery of blood cells and is cost-effective. The study highlights the benefits of using growth factors like GM-CSF in intensive cancer treatment, particularly for patients with relapsed Hodgkin's disease undergoing chemotherapy and AuBMT. Further research is needed to optimize the use of growth factors in cancer treatment, including the timing and duration of administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

12.

Long-term follow-up of a phase III study of recombinant human granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for lymphoid malignancies.

Author: RabinoweS N, NeubergD, BiermanP J, VoseJ M, NemunaitisJ, SingerJ W, FreedmanA S, MauchP, DemetriG, OnettoN

Effective treatment
Long-term safety

rhGM-CSF showed no apparent long-term adverse effects on bone marrow function after autologous bone marrow transplantation (ABMT) for non-Hodgkin's lymphoma, Hodgkin's disease, and acute lymphoblastic leukemia.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

13.

A prospective randomized comparison of total body irradiation-etoposide versus busulfan-cyclophosphamide as preparatory regimens for bone marrow transplantation in patients with leukemia who were not in first remission: a Southwest Oncology Group study.

Author: BlumeK G, KopeckyK J, Henslee-DowneyJ P, FormanS J, StiffP J, LeMaistreC F, AppelbaumF R

Improved survival in leukemia patients
Graft-versus-host disease
Leukemic relapse

This phase III trial of 122 patients with leukemia undergoing allogeneic bone marrow transplantation found that fractionated total body irradiation and etoposide (FTBI/VP-16) and high-dose busulfan with cyclophosphamide (BU/CY) regimens were associated with similar overall survival and disease-free survival rates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

14.

Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. Pediatric Oncology Group.

Author: RavindranathY, YeagerA M, ChangM N, SteuberC P, KrischerJ, Graham-PoleJ, CarrollA, InoueS, CamittaB, WeinsteinH J

AML treatment
Relapse
Treatment related mortality

Treatment of children with AML in first remission with either autologous bone marrow transplantation or intensive chemotherapy prolongs event-free survival equally.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

15.

Allogeneic vs autologous stem cell transplantation vs chemotherapy in patients with acute myeloid leukemia in first remission: the BGMT 87 study.

Author: ReiffersJ, StoppaA M, AttalM, MichalletM, MaritG, BlaiseD, HuguetF, CorrontB, Cony-MakhoulP, GastautJ A, LaurentG, MolinaL, BroustetA, MaraninchiD, PrisJ, HollardD, FaberesC

Improved AML treatment

In a study of 204 people with acute myeloid leukemia (AML), 79.4% achieved complete remission. For those under 46 with a suitable donor, allogeneic bone marrow transplant (alloBMT) resulted in a higher 3-year disease-free survival rate (66.5%) compared to those who did not have a suitable donor and received either autologous stem cell transplant (ASCT) or chemotherapy (42.4%). AlloBMT was also associated with a lower relapse rate. For patients without a suitable donor, there was no significant difference in outcomes between ASCT and chemotherapy. These findings suggest that alloBMT may be the most effective treatment option for eligible patients with AML.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Increased risk of chronic graft-versus-host disease, obstructive bronchiolitis, and alopecia with busulfan versus total body irradiation: long-term results of a randomized trial in allogeneic marrow recipients with leukemia. Nordic Bone Marrow Transplantation Group.

Author: RingdénO, RembergerM, RuutuT, NikoskelainenJ, VolinL, VindeløvL, ParkkaliT, LenhoffS, SallerforsB, MellanderL, LjungmanP, JacobsenN

Leukemia treatment
Alopecia
Cataracts
Graft-versus-host disease
Hemorrhagic cystitis
Obstructive bronchiolitis
Veno-occlusive disease

This study compared the effects of busulfan and total body irradiation (TBI) as conditioning regimens for bone marrow transplantation in leukemic patients. Busulfan was associated with a higher risk of veno-occlusive disease of the liver, hemorrhagic cystitis, and chronic graft-versus-host disease, while TBI was associated with a higher risk of obstructive bronchiolitis and cataracts.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

A prospective study of bone loss and turnover after allogeneic bone marrow transplantation: effect of calcium supplementation with or without calcitonin.

Author: VälimäkiM J, KinnunenK, VolinL, TähteläR, LöyttyniemiE, LaitinenK, MäkeläP, KetoP, RuutuT

Bone loss
Fracture risk
Hypogonadism

This study investigated bone loss after allogeneic bone marrow transplantation (BMT) and the potential benefits of calcium and calcitonin in preventing bone loss. The study found that significant bone loss occurs after BMT and that calcium with or without calcitonin does not prevent it.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

A prospective randomized trial of Filgrastim (r-metHuG-CSF) given at different times after unrelated bone marrow transplantation.

Author: HägglundH, RingdénO, OmanS, RembergerM, CarlensS, MattssonJ

Effective treatment
Reduced costs

A study comparing three different timing regimens for Filgrastim (r-metHuG-CSF) after unrelated bone marrow transplantation (BMT) found no significant differences in hematological recovery, complications, or survival. Starting Filgrastim treatment later (day +10) reduced costs without affecting recovery time.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

Monitoring treatment and survival in chronic myeloid leukemia. Italian Cooperative Study Group on Chronic Myeloid Leukemia and Italian Group for Bone Marrow Transplantation.

Author:

Longer survival

Allogeneic bone marrow transplantation (alloBMT) was associated with significantly longer survival compared to conventional chemotherapy in patients with chronic myeloid leukemia, regardless of age or risk.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

Nutrition support for bone marrow transplant patients.

Author: MurrayS M, PindoriaS

Prevention of malnutrition
Increased infection risk

Bone marrow transplant involves strong medications and the infusion of bone marrow cells. These treatments can cause problems like loss of appetite, mouth sores, and digestive problems, leading to malnutrition. While feeding through a vein (parenteral nutrition) is commonly used, it can increase the risk of infection. Feeding through a tube into the stomach (enteral nutrition) is an alternative, and adding substances like glutamine to feeding solutions is also being studied. However, more research is needed to determine the best way to provide nutrition after bone marrow transplantation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Transplantation of mobilized peripheral blood cells to HLA-identical siblings with standard-risk leukemia.

Author: SchmitzNorbert, BeksacMeral, HasencleverDirk, BacigalupoAndrea, RuutuTapani, NaglerArnon, GluckmanEliane, RussellNigel, ApperleyJane F, GorinNorbert C, SzerJeff, BradstockKen, BuzynAgnes, ClarkPeter, BorkettKeith, GratwohlAlois,

Faster neutrophil recovery
Faster platelet recovery
Hematopoiesis restoration
Acute graft versus host disease
Chronic graft versus host disease

The study compares the use of allogeneic mobilized peripheral blood progenitor cells to bone marrow transplantation for restoring hematopoiesis after myeloablative therapy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

Consolidation therapy with autologous bone marrow transplantation in adults with acute myeloid leukemia: a meta-analysis.

Author: NathanPaul C, SungLillian, CrumpMichael, BeyeneJoseph

This study investigated the best way to continue treatment for adults who have achieved initial remission from acute myeloid leukemia after chemotherapy, but who do not have a matching donor for a bone marrow transplant. The study compared the effectiveness of a transplant using the patient's own bone marrow (autologous transplant) to the effectiveness of non-intense chemotherapy or no further treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Autologous stem cells derived from the peripheral blood compared to standard bone marrow transplant; time to engraftment: a systematic review.

Author: LewisAlly

Peripheral blood stem cell transplantation
High dose chemotherapy
Lymphoma

This review evaluates the evidence for using peripheral blood stem cell transplantation compared to standard bone marrow transplantation in lymphoma patients undergoing high-dose chemotherapy, highlighting the potential benefits of peripheral blood stem cells.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

Nutrition support for bone marrow transplant patients.

Author: MurraySusan M, PindoriaSima

Improved bone marrow transplant treatment
Bone marrow transplantation

Bone marrow transplantation involves strong chemotherapy and the infusion of bone marrow cells. After treatment, many patients experience poor appetite, mouth sores, and digestive problems, leading to malnutrition. While intravenous feeding is often used, it increases the risk of infection. Feeding through a tube into the stomach (enteral nutrition) is an alternative, as is adding specific nutrients to the feeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Impact of disease risk on efficacy of matched related bone marrow transplantation for pediatric acute myeloid leukemia: the Children's Oncology Group.

Author: HoranJohn T, AlonzoTodd A, LymanGary H, GerbingRobert B, LangeBeverly J, RavindranathYaddanapudi, BectonDavid, SmithFranklin O, WoodsWilliam G,

Improved acute myeloid leukemia treatment
Acute myeloid leukemia

There is variation in the use of bone marrow transplantation from a matching relative for children newly diagnosed with acute myeloid leukemia (AML). Some doctors believe it should be offered to most children who achieve remission, while others think it should be reserved for high-risk cases. This study examines how the risk of the disease affects the effectiveness of bone marrow transplantation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

27.

Nutrition support for bone marrow transplant patients.

Author: MurraySusan M, PindoriaSima

Improved bone marrow transplant treatment
Bone marrow transplantation

Bone marrow transplantation involves strong chemotherapy and the infusion of bone marrow cells. After treatment, many patients experience poor appetite, mouth sores, and digestive problems, leading to malnutrition. While intravenous feeding is often used, it increases the risk of infection. Feeding through a tube into the stomach (enteral nutrition) is an alternative, as is adding specific nutrients to the feeding.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

28.

WITHDRAWN: Nutrition support for bone marrow transplant patients.

Author: MurraySusan M, PindoriaSima

Bone marrow transplant treatment

Bone marrow transplantation involves strong chemotherapy and the infusion of new bone marrow cells. After treatment, patients often have problems eating, leading to malnutrition. While intravenous nutrition (PN) is often used, it increases infection risk. Enteral nutrition (EN) and nutritional supplements are potential alternatives. This review updates previous research on this topic.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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