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Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia.

Author: RoehrbornClaus G, SchwinnDebra A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Alpha1-adrenergic receptors (alpha1ARs) are critical mediators of lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Drugs that block these receptors are effective treatments for BPH. Tamsulosin and alfuzosin are two effective drugs that have fewer side effects than nonselective alpha1AR antagonists.
Paper Details　
Original Abstract of the Article :
PURPOSE: We provide a comprehensive overview of the role of alpha1-adrenergic receptors (alpha1ARs) as critical mediators of lower urinary tract symptoms (LUTS) and pathophysiology in benign prostatic hyperplasia (BPH), and we review the pharmacological antagonists of alpha1ARs. MATERIALS AND METHO...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/14767264

データ提供：米国国立医学図書館（NLM）

Alpha1-Adrenergic Receptors: The Key to Unlocking Lower Urinary Tract Symptoms

In the vast landscape of men's health, lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH) present significant challenges. This research dives into the role of alpha1-adrenergic receptors (alpha1ARs), key players in the urinary tract, and their intricate connection to LUTS and BPH. The study delves into the specific subtypes of alpha1ARs, revealing how their distinct distribution within the urinary tract and cardiovascular system influences the development of therapeutic agents. The research underscores the importance of targeting specific alpha1AR subtypes for effective treatment of LUTS and BPH, highlighting the potential for improved drug development.

Unlocking the Potential of Alpha1ARs

The research reveals that targeting specific alpha1AR subtypes, particularly alpha1aAR and alpha1dAR, may hold the key to more effective treatment of LUTS and BPH. The findings suggest that drugs with high selectivity for these subtypes could be more effective in addressing symptoms while minimizing cardiovascular side effects. The study also notes that further investigation into super-selective agents targeting alpha1aAR is warranted.

Navigating the Desert of Urinary Tract Issues

This research offers a promising avenue for addressing LUTS and BPH. Imagine a thirsty camel finding an oasis amidst the vast desert, that's the feeling many men experience when finding relief from urinary symptoms. The study's focus on specific alpha1AR subtypes points to a future where more personalized and effective treatments for these conditions are within reach.

Dr.Camel's Conclusion

In the realm of men's health, understanding the role of alpha1ARs is akin to navigating a treacherous desert with a map. This study provides valuable insights into the complex interplay of these receptors in the urinary tract, paving the way for more targeted and effective treatments for LUTS and BPH. The quest for better therapies for these conditions continues, and this research serves as a vital compass guiding us towards a future where men can navigate the challenges of urinary health with greater ease.

Date :
  1. Date Completed 2004-03-30
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

14767264

DOI: Digital Object Identifier

S0022-5347(05)62407-X

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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