Side Effects of terazosin: A Synthesis of Findings from 27 Studies

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Original Abstract of the Article

Major Research Findings

Terazosin is an alpha-blocker used to treat benign prostatic hyperplasia (BPH). Many studies have shown that terazosin is effective in improving symptoms of BPH. However, terazosin can cause some side effects. 9 showed that side effects of terazosin were mild and improved after discontinuation of treatment. It also suggests that terazosin may reduce the risk of urinary tract infection and myocardial infarction. 1

Terazosin improves the symptoms of BPH by relaxing the urethral sphincter and making urination easier. 8 However, terazosin also has a vasodilating effect, which can lower blood pressure. 10 Terazosin can also affect sexual function and cause erectile dysfunction and ejaculatory disorders. 11 However, the impact of terazosin on sexual function is mild compared to other alpha-blockers. 12

Reasons for Side Effects

The side effects of terazosin are caused by its pharmacological effects. Terazosin is an alpha-1 adrenergic receptor antagonist, which has vasodilating and urethral sphincter relaxing effects. These effects can lower blood pressure and make urination easier. However, these effects can also cause side effects.

Common Side Effects

Dizziness

Terazosin can cause dizziness by lowering blood pressure. 1

Asthenia

Terazosin can cause asthenia by lowering blood pressure. 1

Peripheral edema

Terazosin can cause peripheral edema due to its vasodilating effect. 1

Erectile dysfunction

Terazosin can cause erectile dysfunction by affecting sexual function. 11 However, the impact of terazosin on erectile dysfunction is mild compared to other alpha-blockers. 12

Ejaculatory disorders

Terazosin can cause ejaculatory disorders by affecting sexual function. 11

Side Effect Management

Dizziness

When taking terazosin, be sure to get up slowly when standing up. 1

Asthenia

When taking terazosin, get enough rest. 1

Peripheral edema

When taking terazosin, rest with your feet raised. 1

Erectile dysfunction

If you experience erectile dysfunction while taking terazosin, consult your doctor. 11

Ejaculatory disorders

If you experience ejaculatory disorders while taking terazosin, consult your doctor. 11

Comparison between Studies

Commonalities of Studies

Many studies have shown that terazosin is effective in improving symptoms of BPH. 9 It also suggests that terazosin has a mild impact on sexual function compared to other alpha-blockers. 12

Differences between Studies

The incidence and severity of side effects of terazosin vary from study to study. 1 This is likely due to differences in the age and health of the subjects, and the dosage of terazosin.

Real-Life Application Precautions

While terazosin has been shown to be effective in improving BPH symptoms, it also carries the risk of side effects. When taking terazosin, be sure to follow your doctor's instructions carefully and consult your doctor immediately if you experience any side effects. 9

Current Research Limitations

Research on the side effects of terazosin is still insufficient. 10 In particular, further research is needed on the long-term side effects of terazosin.

Future Research Directions

Studies are needed to evaluate the long-term side effects of terazosin. 10 It is also necessary to compare the side effects of terazosin with other alpha-blockers. 12

Conclusion

Terazosin has been shown to be effective in improving symptoms of BPH. 9 However, terazosin can cause some side effects. 1 When taking terazosin, be sure to follow your doctor's instructions carefully and consult your doctor immediately if you experience any side effects.

Literature analysis of 27 papers
Positive Content
22
Neutral Content
1
Negative Content
4
Article Type
2
2
4
16
27
1.

Side effects of terazosin in the treatment of symptomatic benign prostatic hyperplasia.

Author: McKiernanJ M, LoweF C

Reduced risk of MI
Reduced risk of UTI
Asthenia
Dizziness
Peripheral edema

Terazosin is a safe and effective treatment for symptomatic benign prostatic hyperplasia with minimal clinically significant side effects. The most common side effects were dizziness (10.7%), asthenia (7.5%), and peripheral edema (4.0%).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

2.

Adverse events related to alpha-blockers: analysis of real-life data from Eudra-Vigilance.

Author: CicioneAntonio, NacchiaAntonio, BaldassarriValeria, TemaGiorgia, RovestiLorenzo M, ManciniElisa, GuarnottaGiorgio, VoglinoOlivia A, FrancoAntonio, D'AnnunzioSimone, LombardoRiccardo, TubaroAndrea, DE NunzioCosimo

Alfuzosin safety
Ejaculatory disorders
Orthostatic hypotension

This study analyzed real-life data on neuro-vascular and sexual adverse events (AEs) associated with alpha-blockers (ABs) reported to the Eudra-Vigilance database. The study found that silodosin had a significantly higher risk of ejaculatory disorders, while tamsulosin and silodosin had a lower risk of orthostatic hypotension compared to other ABs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Beneficial Extracardiac Effects of Cardiovascular Medications.

Author: ButtAsra K, PatelJay, ShirwanyHamid, MirzaQasim, HooverJonathan, KhouzamRami N

Non-cardiovascular treatment

This review article discusses how the various extracardiovascular effects of commonly used cardiovascular medications are put to use in managing non-cardiovascular conditions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

Impact of medical treatments for male lower urinary tract symptoms due to benign prostatic hyperplasia on ejaculatory function: a systematic review and meta-analysis.

Author: GacciMauro, FicarraVincenzo, SebastianelliArcangelo, CoronaGiovanni, SerniSergio, ShariatShahrokh F, MaggiMario, ZattoniFiliberto, CariniMarco, NovaraGiacomo

Ejaculatory dysfunction

Alpha-blockers and 5ARIs are associated with a higher risk of ejaculatory dysfunction (EjD) than placebo. Combination therapy with both drug classes results in a 3-fold increased risk of EjD.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

6.

Comparison of terazosin and prazosin for treatment of vesico-urethral reflex dyssynergia in dogs.

Author: HaagsmanA N, KummelingA, MoesM E, MesuS J, KirpensteijnJ

Prazosin for VURD
Terazosin for VURD
Side effects of terazosin

This study compared the efficacy and side effects of prazosin and terazosin in treating dogs with vesico-urethral reflex dyssynergia (VURD). Significantly more side effects were seen in dogs treated with terazosin.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

WITHDRAWN: Terazosin for benign prostatic hyperplasia.

Author: WiltTimothy J, HoweR William, RutksIndy, MacdonaldRoderick

Terazosin BPO
Terazosin adverse effects

This systematic review of 17 studies found that terazosin improved urinary symptoms and flow measures associated with benign prostatic obstruction (BPO) more than placebo or finasteride, but less than microwave therapy. Adverse effects, including dizziness, asthenia, headache, and postural hypotension, were more frequent than with other alpha-blockers and associated with increased treatment discontinuation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

9.

[Using setegis (terasosine) in early postoperative period after transurethral prostate resection].

Author: TeodorovichO V, ZabrodinaN B, BochkarevA B

Prostatic adenoma treatment

This study evaluated the effectiveness and safety of terasosine in the early postoperative period after TURP (transurethral resection of the prostate) for prostatic adenoma. Terasosine significantly improved clinical parameters, shortened hospital stay, and reduced residual urine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

10.

[The risk of fracture with taking alpha blockers for treating benign prostatic hyperplasia].

Author: LeeJoongyub, ChoiNam Kyoung, JungSun Young, KimYe Jee, SeongJong Mi, OhSeung June, ParkByung Joo

Fracture risk
Hypotension

Alpha blockers for benign prostatic hyperplasia may increase the risk of fracture in elderly patients with comorbidities.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Korean

11.

Association of sexual dysfunction with lower urinary tract symptoms of BPH and BPH medical therapies: results from the BPH Registry.

Author: RosenRaymond C, WeiJohn T, AlthofStanley E, SeftelAllen D, MinerMartin, PerelmanMichael A,

Ejaculatory dysfunction
Erectile dysfunction

Lower urinary tract symptoms (LUTS) have been associated with erectile dysfunction (ED) and ejaculatory dysfunction (EjD) in epidemiological studies. This study examined these relationships in a physician office-based population of men with LUTS suggestive of benign prostatic hyperplasia (LUTS/BPH).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

[Alpha blockers in use for symptomatic benign prostatic hyperplasia--are all drugs born equal?].

Author: Bar-YosefYuval, MabjeeshNicola J, LauferMenachem, NeulanderEndre Z, KaverIsaac, MatzkinHaim

BPH treatment
Ejaculatory dysfunction
Hypotension

This paper compares the efficacy and adverse events profile of four alpha-adrenergic blockers used for the treatment of symptomatic benign prostatic hyperplasia (BPH): terazosin, doxazosin, alfuzosin, and tamsulosin. Alfuzosin and tamsulosin are preferred due to their better tolerability and ease of use.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Hebrew

13.

Sexual function in hypertensive patients receiving treatment.

Author: ReffelmannThorsten, KlonerRobert A

ED tx
ED drug risks

Erectile dysfunction (ED) is often associated with cardiovascular risk factors, particularly arterial hypertension. This abstract discusses the relationship between ED and cardiovascular disease and the management of ED in hypertensive patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Comorbid LUTS and erectile dysfunction: optimizing their management.

Author: KaminetskyJed

Reduced quality of life

This article discusses the relationship between lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH) and erectile dysfunction (ED). It explores the diagnostic workup, treatment options, and potential effects of treatments on this population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Treatment and pharmacologic management of BPH in the context of common comorbidities.

Author: O'LearyMichael P

BPH treatment
Sexual side effects

Benign prostatic hyperplasia (BPH) is common in older men and can cause lower urinary tract symptoms (LUTS). Drug treatment for BPH aims to relax prostatic smooth muscle and reduce prostate size. Alpha1-adrenergic receptor antagonists and 5-alpha-reductase inhibitors are commonly used. While transurethral resection of the prostate (TURP) is effective for LUTS, it carries a higher risk of complications and sexual side effects than medical therapy or minimally invasive techniques.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

17.

BPH: epidemiology and comorbidities.

Author: McVaryKevin T

LUTS/BPH treatment
Side effects

Benign prostatic hyperplasia (BPH) is common in older men. Alpha1-selective adrenergic receptor (a1-AR) antagonists and 5-alpha-reductase inhibitors are effective treatments for BPH. It is important to consider side effects and their potential impact on existing comorbidities when selecting a treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

19.

Sexual dysfunction and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH).

Author: RosenRaymond C, GiulianoFrancois, CarsonCulley C

Improved LUTS
Improved sexual function
Sexual dysfunction

Benign prostatic hyperplasia (BPH) is a common condition that can affect sexual function in older men. This article discusses the relationship between BPH and sexual dysfunction, including erectile dysfunction and ejaculatory dysfunction. It also explores the impact of various treatments for BPH on sexual function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

20.

The use and rationale of selective alpha blockade in children with non-neurogenic neurogenic bladder dysfunction.

Author: BogaertGuy, BeckersGoedele, LombaertsRita

Improved bladder function
Safe long-term use

This study evaluated the safety and efficacy of long-term terazosine in association with prophylactic antibiotics, timed voiding, and a bowel regimen in two children with Hinman's syndrome.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Multicenter drug use evaluation of tamsulosin and availability of guidance criteria for nonformulary use in the veterans affairs health system.

Author: BurkMuriel, FurmagaElaine, DongDiane, CunninghamFrancesca

Cost avoidance

This study examined the use of tamsulosin, a drug used to treat enlarged prostate, in the U.S. Department of Veterans Affairs (VA). The study found that many VA patients were prescribed tamsulosin for uses that were not consistent with national guidelines.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
CommentA short article/note that provides an opinion/perspective/interpretation on a published paper/topic.

Language : English

22.

Therapy of ED: PDE-5 Inhibitors.

Author: ShabsighRidwan

Erectile dysfunction treatment
Reduced side effects
Drug interactions

This study reviews the use of phosphodiesterase inhibitors for the treatment of erectile dysfunction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

23.

Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia.

Author: RoehrbornClaus G, SchwinnDebra A

Reduced LUTS
Possible ejaculatory side effects

Alpha1-adrenergic receptors (alpha1ARs) are critical mediators of lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH). Drugs that block these receptors are effective treatments for BPH. Tamsulosin and alfuzosin are two effective drugs that have fewer side effects than nonselective alpha1AR antagonists.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

24.

[Pharmacologic treatment of benign prostatic hyperplasia].

Author: RomicsImre

Improved dysuria
Reduced prostate volume
Hypotension

Herbal extracts are recommended as an initial treatment for benign prostatic hyperplasia (BPH) due to their effectiveness, lack of side effects, and affordability. Finasteride, a 5-alpha reductase inhibitor, is indicated when the prostate volume is over 40 g. Receptor blockers that act on the bladder neck are recommended for all BPH patients, regardless of prostate volume.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Hungarian

25.

Terazosin therapy for chronic prostatitis/chronic pelvic pain syndrome: a randomized, placebo controlled trial.

Author: CheahPhaik Yeong, LiongMen Long, YuenKah Hay, TehChu Leong, KhorTimothy, YangJin Rong, YapHin Wai, KriegerJohn N

Chronic prostatitis relief
Side effects

Terazosin proved superior to placebo for patients with chronic prostatitis/chronic pelvic pain syndrome who had not received alpha-blockers previously.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Terazosin for benign prostatic hyperplasia.

Author: WiltT J, HoweR W, RutksI R, MacDonaldR

Improved flow measures
Improved urinary symptoms
Asthenia
Dizziness
Headache
Postural hypotension

Terazosin effectively improved urinary symptoms and flow measures associated with benign prostatic obstruction (BPO). Efficacy was superior to placebo or finasteride, similar to other alpha-blockers but less than transurethral microwave thermotherapy. Adverse effects were generally mild but more frequent than other alpha-blockers and associated with between a two-four fold increase in treatment discontinuation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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