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In vitro effects of nitazoxanide on Echinococcus granulosus protoscoleces and metacestodes.

Author: HemphillAndrew, RossignolJean François, TorgersonPaul, WalkerMirjam

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Nitazoxanide is a broad-spectrum drug used against intestinal parasites and bacteria. In vitro studies suggest that it may be an effective treatment option for cystic echinococcosis (CE), a parasitic disease caused by the larval stage of Echinococcus granulosus. This drug is a potential alternative to benzimidazole carbamate derivatives, such as mebendazole and albendazole, which have significant side effects when used in high doses for long periods of time.
Paper Details　
Original Abstract of the Article :
Infection of humans and domestic ruminants with the larval stage (metacestode) of Echinococcus granulosus results in cystic echinococcosis (CE). The metacestode causes a space-occupying lesion in visceral organs, most commonly in the liver. Benzimidazole carbamate derivatives, such as mebendazole an...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15282238

データ提供：米国国立医学図書館（NLM）

Exploring Nitazoxanide as a Potential Treatment for Cystic Echinococcosis

The medical community constantly seeks new and effective treatments for parasitic infections. This study investigates the potential of nitazoxanide, a broad-spectrum drug, as a treatment option for cystic echinococcosis (CE), a parasitic infection caused by the larval stage of Echinococcus granulosus. The researchers conducted in vitro studies to evaluate the drug's efficacy against the parasite, seeking alternative therapeutic approaches to the current standard treatment, benzimidazole carbamate derivatives. This study offers valuable insights into the potential of nitazoxanide as a promising treatment option for CE.

Nitazoxanide Shows Promise Against Cystic Echinococcosis

The in vitro results suggest that nitazoxanide demonstrates significant efficacy against Echinococcus granulosus, offering a potential alternative to current treatments. The findings suggest that nitazoxanide could be a viable therapeutic option for CE, potentially leading to improved treatment outcomes for patients.

A Hope for Improved Treatment Outcomes

As a doctor, I'm always looking for ways to improve patient care. The study's exploration of nitazoxanide as a potential treatment for CE is particularly exciting. It offers hope for patients suffering from this debilitating disease, as it may lead to more effective and potentially less toxic treatment options. It's a reminder that research is constantly pushing the boundaries of medicine, bringing us closer to better treatments for a wide range of conditions.

Dr.Camel's Conclusion

This study showcases the ongoing quest for better treatments in medicine. By exploring the potential of nitazoxanide as a therapeutic option for cystic echinococcosis, the researchers highlight the commitment to finding new and effective ways to combat parasitic infections.

Date :
  1. Date Completed 2004-10-26
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

15282238

DOI: Digital Object Identifier

dkh386

SNS
PICO Info
in preparation
Languages

English

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