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Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy.

Author: HolliwellD L, LeenenF H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Felodipine, a calcium antagonist, rapidly reduced blood pressure and total peripheral resistance but caused sympathetic hyperactivity, which may limit the regression of left ventricular hypertrophy.
Paper Details　
Original Abstract of the Article :
Twenty patients whose systemic hypertension was not controlled with chronic beta-blocker therapy were studied to evaluate the acute (first dose), short-term (4 weeks) and chronic (6 to 12 months) effects of the calcium antagonist felodipine on blood pressure (BP), left ventricular (LV) anatomy and f...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9149(92)90156-s

データ提供：米国国立医学図書館（NLM）

Felodipine: A Powerful Antihypertensive with Unforeseen Consequences

This study, like a caravan venturing through a desert of hypertension, explores the effects of felodipine, a calcium antagonist, on blood pressure, left ventricular structure, and function. The researchers studied 20 patients with uncontrolled hypertension, observing the effects of felodipine both acutely and chronically. Interestingly, the study revealed that while felodipine effectively reduced blood pressure, it was also associated with persistent sympathetic activation, suggesting a potential trade-off between its benefits and side effects. Furthermore, despite significant blood pressure reduction, the drug led to only modest regression of left ventricular hypertrophy, raising concerns about its long-term impact on cardiovascular health.

The Paradox of Felodipine: Effective but Complicated

The study highlights a complex picture with felodipine. It is effective in lowering blood pressure but also causes a persistent increase in sympathetic activity, potentially leading to long-term cardiovascular complications. This intricate interplay of benefits and risks necessitates careful patient monitoring and individualized treatment strategies.

Navigating the Desert of Hypertension

This study serves as a reminder of the intricate nature of hypertension and the need for careful consideration of the potential trade-offs associated with different treatment strategies. It highlights the importance of finding the right balance between controlling blood pressure and mitigating potential cardiovascular risks.

Dr.Camel's Conclusion

This study reveals the intricacies of felodipine as a treatment for hypertension. While it effectively lowers blood pressure, it also poses potential long-term risks due to persistent sympathetic activation. Understanding this complex interplay is essential for optimizing patient care and ensuring the most favorable outcomes.
Date :
  1. Date Completed 1992-03-26
  2. Date Revised 2019-06-22
Further Info :

Pubmed ID

1531566

DOI: Digital Object Identifier

10.1016/0002-9149(92)90156-s

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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