Effects of felodipine: A Synthesis of Findings from 10 Studies

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Original Abstract of the Article

Major Research Findings

Felodipine is a calcium channel blocker that is used to treat angina pectoris and hypertension. Several studies have shown that felodipine is an effective treatment for these conditions. For example, a 3 study showed that felodipine reduced the number of angina attacks and the consumption of nitroglycerin in patients with angina pectoris. Another study, 7 , showed that felodipine reduced blood pressure in hypertensive patients with type 2 diabetes. A study, 1 , showed that felodipine improved left ventricular hypertrophy in patients with hypertension.

Benefits and Risks

Benefit Summary

Felodipine is an effective drug for treating angina pectoris and hypertension. In patients with angina pectoris, it can reduce the frequency of angina attacks and decrease the need for nitroglycerin. In patients with hypertension, it can reduce blood pressure. Felodipine may also be beneficial in improving left ventricular hypertrophy.

Risk Summary

Common side effects of felodipine include peripheral edema, headache, dizziness, flushing, and fatigue. Felodipine can also decrease theophylline blood levels, so caution is needed if it is used in combination with theophylline. Furthermore, felodipine should be avoided during pregnancy.

Comparison of Studies

Commonalities

Multiple studies have shown that felodipine is an effective treatment for angina pectoris and hypertension. Felodipine is generally considered to be a safe drug. However, because of the potential side effects, it is important to take it as prescribed by your doctor.

Differences

There are some differences in the effects and side effects of felodipine across studies. For example, a 3 study showed that felodipine reduced the frequency of angina attacks, but a 7 study showed that felodipine could affect blood sugar levels. A study, 1 , showed that felodipine improved left ventricular hypertrophy, but another study, 4 , showed that felodipine had no significant difference in blood pressure reduction compared with atenolol.

Consistency and Contradictions in Results

Multiple studies have shown that felodipine is an effective drug for treating angina pectoris and hypertension. However, there are some differences in the effects and side effects of felodipine across studies. These differences could be due to factors such as the characteristics of the study subjects, the study design, and the dosage. Felodipine may also interact with other drugs, such as theophylline, potentially lowering theophylline blood levels. Therefore, it is important to consult with your doctor if you are considering taking felodipine.

Considerations for Real-World Application

Felodipine is an effective drug for treating angina pectoris and hypertension. However, it is important to take it as prescribed by your doctor, as it has potential side effects and drug interactions. In particular, it should be avoided during pregnancy. It is also important to monitor your blood pressure and heart rate regularly when taking felodipine.

Limitations of Current Research

While research on felodipine has yielded many findings, there are still some areas that require further research. For example, more detailed research is needed on the combined effects of felodipine with other drugs. Further research is also needed on the long-term safety and effectiveness of felodipine.

Directions for Future Research

Future research on felodipine should include more detailed studies on the combined effects of felodipine with other drugs. Large-scale clinical trials are needed to examine the long-term safety and effectiveness of felodipine. Further research on other diseases for which felodipine may be beneficial is also important.

Conclusion

Felodipine is an effective drug for treating angina pectoris and hypertension. However, it is important to take it as prescribed by your doctor, as it has potential side effects and drug interactions. Further research is expected to clarify the effects and safety of felodipine. Please consult with your doctor if you have any concerns or questions about felodipine.

Literature analysis of 10 papers
Positive Content
10
Neutral Content
0
Negative Content
0
Article Type
10
0
0
1
10
1.

Antihypertensive effect of felodipine associated with persistent sympathetic activation and minimal regression of left ventricular hypertrophy.

Author: LeenenF H, HolliwellD L

Blood pressure control
Sympathetic hyperactivity

Felodipine, a calcium antagonist, rapidly reduced blood pressure and total peripheral resistance but caused sympathetic hyperactivity, which may limit the regression of left ventricular hypertrophy.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Felodipine: a new dihydropyridine calcium-channel antagonist.

Author: YedinakK C, LopezL M

Improves heart function
Lowers blood pressure
Safe for long-term use
Dizziness
Drug interactions
Fatigue
Flushing
Headache
Peripheral edema

Felodipine, a dihydropyridine calcium-channel antagonist, effectively reduces systolic and diastolic blood pressure in patients with hypertension. It is at least as efficacious as hydrochlorothiazide (HCTZ) and HCTZ plus amiloride hydrochloride in combination. Felodipine is also effective as an adjunct to beta-blocker or diuretic therapy. The most common adverse effects are peripheral edema, headache, dizziness, flushing, and fatigue. Clinically significant drug interactions have been observed with theophylline aminopropanol, leading to significant decreases in theophylline concentrations.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

The effects of felodipine in angina pectoris.

Author: LorimerA R, MacFarlaneP, PringleS, BarbourM P, FoxY, LawrieT D

Anti-anginal
Improved exercise tolerance
Reduced angina attacks
Reduced blood pressure
None reported

Felodipine, in addition to a beta-blocker, modestly but significantly reduced the number of angina attacks and increased exercise capacity in patients with exertional angina pectoris.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

[Felodipine in arterial hypertension. Double-blind comparison with atenolol].

Author: AndrejakM, WitchitzS, MorandP, LesbreJ P, Raveau-LandonC

Antihypertensive efficacy
Ankle oedema
Fatigue
Headache

Felodipine, a dihydropyridine calcium antagonist, effectively lowers blood pressure in hypertensive patients. In a multicenter double-blind study, felodipine and atenolol were comparable in their antihypertensive effects, with both drugs significantly lowering blood pressure. Side effects of felodipine included ankle edema and headache, while atenolol was associated with fatigue and headache.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

5.

Antihypertensive efficacy of the calcium-antagonist felodipine in patients with persisting hypertension on beta-adrenoceptor blocker therapy. The Canadian Felodipine Study Group.

Author:

Reduced blood pressure
Ankle swelling
Flushing

Felodipine was found to be effective in lowering blood pressure in hypertensive patients already on beta-blockers. Both initial blood pressure level and plasma felodipine concentrations were predictors of the response, while age was not.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Felodipine--a new vasodilator, in addition to beta-receptor blockade in hypertension.

Author: ElmfeldtD, HednerT

Reduces blood pressure
Ankle edema
Headache

Adding felodipine to beta-blocker treatment in hypertensive patients lowered blood pressure and slightly increased heart rate. Headache and ankle edema were common side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Short-term effects of felodipine in hypertensive type II diabetic males on sulfonylurea treatment.

Author: KjellströmT, BlychertE, LindgärdeF

Reduced blood pressure
Increased HbA1c

Felodipine, a calcium antagonist, was found to be an effective agent for treating type II diabetic patients on glibenclamide treatment. The study involved 17 hypertensive type II diabetic males. Felodipine significantly reduced blood pressure and slightly increased heart rate. It did not influence insulin or c-peptide levels, but it did increase HbA1c.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Felodipine in addition to beta-adrenergic blockade for angina pectoris. a multicentre, randomized, placebo-controlled trial.

Author: RønnevikP K, SilkeB, OstergaardO

Angina pectoris
Beta-blocker
Felodipine
Side effects

Felodipine demonstrated a sustained improvement in exercise duration in patients with stable angina pectoris.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Haemodynamic and renal effects of felodipine in young and elderly subjects.

Author: LernfeltB, LandahlS, JohanssonP, SeligmanL, AbergJ

Blood pressure reduction
Renal vascular resistance reduction
Systemic vascular resistance reduction

Felodipine had similar effects on central and renal hemodynamics in both young and elderly subjects. While the drug lowered blood pressure and vascular resistance in both groups, the effects were more pronounced in elderly individuals. However, there was no effect on glomerular filtration rate.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Effect of oral felodipine on ocular circulation.

Author: SchocketL S, GrunwaldJ E, DupontJ

Felodipine, a calcium channel blocker, did not significantly affect retinal, optic nerve rim, or foveolar choroidal blood flow in healthy volunteers. The study involved 10 volunteers who received placebo or felodipine in a double-blind, randomized, crossover design. This suggests that felodipine may be a safe treatment option for systemic hypertension in patients with glaucoma.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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