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Prednisone plus methotrexate for polymyalgia rheumatica: a randomized, double-blind, placebo-controlled trial.

Author: , CaporaliRoberto, CimminoMarco A, FerraccioliGianfranco, GerliRoberto, KlersyCatherine, MontecuccoCarlomaurizio, SalvaraniCarlo

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Prednisone plus methotrexate was associated with shorter prednisone treatment and steroid sparing in patients with polymyalgia rheumatica. It may be a useful alternative for patients at high risk for steroid-related toxicity.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Steroids are the standard treatment for polymyalgia rheumatica. The efficacy of the candidate drug methotrexate has not yet been demonstrated in controlled studies. OBJECTIVE: To compare the efficacy and safety of prednisone plus methotrexate and prednisone alone in patients with polymy...See full text at original site
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引用元：
https://doi.org/10.7326/0003-4819-141-7-200410050-00005

データ提供：米国国立医学図書館（NLM）

Methotrexate: A Potential Steroid-Sparing Agent for Polymyalgia Rheumatica

This study explores the efficacy of methotrexate, a disease-modifying antirheumatic drug, as a potential steroid-sparing agent for the treatment of polymyalgia rheumatica (PMR), a condition characterized by muscle pain and stiffness. The study involved 72 patients with newly diagnosed PMR, randomly assigned to receive prednisone alone or prednisone combined with methotrexate. The findings demonstrated that methotrexate significantly reduced the duration of prednisone treatment, suggesting its potential to reduce the long-term risks associated with steroid use.

Navigating the Desert of Polymyalgia Rheumatica: Finding Relief

This research offers a glimmer of hope for patients with PMR, suggesting a potential strategy to reduce reliance on steroids. The findings suggest that methotrexate may provide a valuable alternative for managing PMR, offering a way to minimize the potential side effects associated with prolonged steroid use. It's like finding a refreshing oasis in the midst of a harsh desert, providing relief from the discomfort and limitations of PMR.

Beyond the Sands: Exploring New Treatments for PMR

This study encourages further exploration of alternative treatments for PMR, highlighting the potential benefits of methotrexate in reducing steroid dependence. The findings suggest that continued research is crucial to develop effective and safe treatment options for this debilitating condition. It's like a camel trekking across a vast desert, seeking new and innovative routes to reach its destination.

Dr.Camel's Conclusion

This study provides evidence for the potential of methotrexate as a steroid-sparing agent for polymyalgia rheumatica. It underscores the importance of continued research to develop effective and safe treatment options for this condition. It's a reminder that the search for solutions is ongoing, just as a camel tirelessly traverses the desert in search of a hidden oasis.

Date :
  1. Date Completed 2004-10-22
  2. Date Revised 2019-06-19
Further Info :

Pubmed ID

15466766

DOI: Digital Object Identifier

10.7326/0003-4819-141-7-200410050-00005

SNS
PICO Info
in preparation
Languages

English

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