Effective treatment of polymyalgia rheumatica: A Synthesis of Findings from 20 Studies

  1. Home
  2. Effective treatment of polymyalgia rheumatica
This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Effective treatment of polymyalgia rheumatica: A Synthesis of Findings from 20 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

This analysis is based on research papers included in PubMed, but medical research is constantly evolving and may not fully reflect the latest findings. There may also be biases towards certain research areas.

This information is not medical advice and is not a substitute for diagnosis or treatment by a physician. If you have concerns about "Effective treatment of polymyalgia rheumatica: A Synthesis of Findings from 20 Studies", please consult your doctor.

For NLM copyright information, please see Link to NLM Copyright Page
PubMed data is obtained via Hugging Face Datasets: Link to DatasetPlease check the disclaimer.
This page's analysis is based on PubMed data provided by the U.S. National Library of Medicine (NLM).
Original Abstract of the Article

Key Research Findings

Polymyalgia rheumatica (PMR) is a common inflammatory condition that primarily affects older adults. While the exact cause of PMR is unknown, it's characterized by muscle pain and stiffness, especially in the shoulders, neck, and hips. The standard treatment for PMR is corticosteroids, which effectively reduce inflammation and improve symptoms. However, long-term corticosteroid use can lead to side effects like weight gain, bone thinning, and increased risk of infections.

Several studies have investigated alternative treatment approaches for PMR, exploring ways to reduce corticosteroid dependence and minimize side effects. 6 compared the effectiveness and safety of intramuscular methylprednisolone (i.m. MP) with oral prednisolone (OP) in a 96-week trial. The results showed that both treatments led to similar remission rates and long-term disease control. Importantly, i.m. MP was associated with significantly fewer fractures and less weight gain compared to OP, likely due to the lower cumulative dose.

10 delved into the disease mechanisms of PMR, focusing on the muscles. The study found elevated levels of inflammatory cytokines within the muscles of PMR patients, suggesting that muscle inflammation may play a role in the condition's development.

13 , a comprehensive review of evidence, indicated that while the initial dose and tapering regimen of corticosteroids remain a subject of ongoing research, intramuscular methylprednisolone and methotrexate show potential as corticosteroid-sparing agents. This review also highlighted female sex, high erythrocyte sedimentation rate (ESR), and peripheral arthritis as potential risk factors for a more challenging PMR course.

7 investigated the combined use of prednisone and methotrexate, but found no significant benefit over prednisone alone.

4 explored the possibility of using methotrexate to reduce corticosteroid dependence in PMR and giant cell arteritis, but the results were inconclusive.

12 compared prednisone and methylprednisolone, showing that methylprednisolone led to a faster response and quicker remission.

Other studies have explored the effectiveness of different medications: 18 investigated tocilizumab, an interleukin-6 inhibitor, finding potential benefits in reducing disease activity in patients already receiving corticosteroids. 17 further explored the role of tocilizumab in newly diagnosed PMR patients, suggesting its potential as an effective treatment option. 20 focused on sarilumab, another interleukin-6 inhibitor, finding potential for managing PMR relapses during corticosteroid tapering. 1 investigated tenidap, a nonsteroidal anti-inflammatory drug, showing potential for reducing corticosteroid dependence. 19 examined the safety and efficacy of tofacitinib, a JAK inhibitor, indicating its potential as a treatment option.

While 8 looked into the use of infliximab, a tumor necrosis factor (TNF) inhibitor, in initial PMR treatment, it found no significant benefit. 16 , a systematic review, highlighted the ongoing challenge of long-term corticosteroid use and high relapse rates in PMR management.

Treatment Summary

Research on PMR treatment continues to evolve, and while corticosteroids remain the cornerstone of therapy, ongoing efforts focus on finding safer and more effective alternatives. 6 demonstrated the potential benefits of intramuscular methylprednisolone, which may lead to lower cumulative doses and fewer side effects compared to oral prednisolone. Other promising therapies include interleukin-6 inhibitors like tocilizumab and sarilumab, as well as JAK inhibitors like tofacitinib. However, more research is needed to determine the optimal use of these medications and their long-term effects.

Benefits and Risks

Benefits Summary

The primary benefit of PMR treatment is the reduction of inflammation and pain, allowing for improved mobility and quality of life. Studies have shown that corticosteroids effectively achieve this goal. Some studies suggest that intramuscular methylprednisolone may offer additional advantages over oral prednisolone, potentially leading to fewer side effects and lower cumulative doses.

Risks Summary

The main risk associated with PMR treatment is the potential for side effects from corticosteroids. These side effects can include weight gain, bone thinning (osteoporosis), high blood pressure, increased risk of diabetes, cataracts, glaucoma, and increased susceptibility to infections. Long-term corticosteroid use can increase the risk of these side effects. Other medications, like methotrexate, may also carry risks, such as liver damage or blood cell abnormalities.

Comparison of Studies

Commonalities

Many studies agree that corticosteroids are the most effective treatment for PMR. They also underscore the importance of reducing corticosteroid dependence due to potential long-term side effects, leading to ongoing research into alternative therapies and strategies for corticosteroid tapering.

Differences

Research on PMR treatments has shown variability in outcomes. For example, studies on methotrexate have yielded conflicting results, with some showing benefits while others finding no significant effects. This variability reflects the complexity of the disease and underscores the need for further research to refine treatment approaches and identify optimal medications.

Consistency and Contradictions in Results

The findings on PMR treatment are not entirely consistent, with some studies showing contradictory results, particularly regarding the effectiveness of methotrexate. This highlights the need for further research to clarify the role of different medications and treatment strategies in PMR management.

Implications for Daily Life

The best treatment for PMR varies depending on individual factors, including the severity of symptoms, age, and any coexisting health conditions. It's crucial to consult a physician to determine the most appropriate treatment plan. If you're taking corticosteroids, it's essential to discuss potential side effects and strategies for management with your doctor.

Limitations of Current Research

Research on PMR treatment is still ongoing, with several limitations. Further research is needed to fully understand the long-term effectiveness of various treatment options, their potential side effects, and optimal strategies for corticosteroid tapering.

Future Research Directions

Future research in PMR should focus on identifying safe and effective alternatives to corticosteroids, particularly those that can minimize the long-term risks of corticosteroid use. Investigating the effectiveness of different treatment combinations and personalized therapy approaches for PMR is also crucial.

Conclusion

Polymyalgia rheumatica is a common inflammatory condition primarily affecting older adults. While corticosteroids are the mainstay of treatment, ongoing research aims to identify safer and more effective alternatives. Working closely with a physician to create a personalized treatment plan and manage any potential side effects is crucial for effectively managing PMR and improving quality of life.

Treatment Keyword List

  • Corticosteroids
  • Intramuscular methylprednisolone (i.m. MP)
  • Oral prednisolone (OP)
  • Methotrexate
  • Tocilizumab
  • Sarilumab
  • Tenidap
  • Tofacitinib
  • Infliximab
Literature analysis of 20 papers
Positive Content
16
Neutral Content
2
Negative Content
2
Article Type
14
1
6
5
20
1.

Steroid sparing activity of tenidap in patients with polymyalgia rheumatica: a multicenter double blind randomized placebo controlled study.

Author: LittmanB H, BjarnasonD, BryantG, EngelbrechtJ, CohenM, MertzL, WeaverA, HunderG G

PMR treatment

Tenidap was more effective than placebo in controlling symptoms of PMR as prednisone was reduced. 45% of patients receiving tenidap were able to discontinue prednisone without a disease flare compared to 6% for placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

The clinical and laboratory course of polymyalgia rheumatica/giant cell arteritis after the first two months of treatment.

Author: KyleV, HazlemanB L

Relapse
Steroid dependence

This prospective study examined the clinical course of polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) after the initial two months. The study involved 74 patients with PMR/GCA. The study found that most patients experienced at least one relapse after two months, and relapses were most common in the first year.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Methotrexate in polymyalgia rheumatica: preliminary results of an open, randomized study.

Author: FerraccioliG, SalaffiF, De VitaS, CasattaL, BartoliE

Bone sparing
Reduced prednisone use

Adding methotrexate to prednisone therapy for polymyalgia rheumatica (PMR) allowed for significantly lower prednisone doses while maintaining efficacy and reducing bone loss.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Can methotrexate be used as a steroid sparing agent in the treatment of polymyalgia rheumatica and giant cell arteritis?

Author: van der VeenM J, DinantH J, van Booma-FrankfortC, van Albada-KuipersG A, BijlsmaJ W

Reduced prednisone use

Methotrexate did not show a steroid-sparing effect in the treatment of polymyalgia rheumatica and giant cell arteritis when combined with a rapid steroid tapering regimen. The study found that the mean daily prednisone dose could be reduced by 50% in 21 weeks and discontinued in 40% of patients within two years.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Effects of inflammation and treatment on bone turnover and bone mass in polymyalgia rheumatica.

Author: DolanA L, MonizC, DasguptaB, LiF, MackintoshC, ToddP, CorrigallV, PanayiG S

Bone loss

This study investigated the impact of both systemic inflammation and corticosteroid therapy on bone loss in patients with polymyalgia rheumatica (PMR), which requires corticosteroid treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

An initially double-blind controlled 96 week trial of depot methylprednisolone against oral prednisolone in the treatment of polymyalgia rheumatica.

Author: DasguptaB, DolanA L, PanayiG S, FernandesL

Disease control
Reduced steroid side-effects
Fractures
Polymyalgia rheumatica
Steroid side-effects
Weight gain

This study compared the efficacy and safety of intramuscular methylprednisolone acetate (i.m. MP) with oral prednisolone (OP) in treating polymyalgia rheumatica (PMR). I.m. MP was associated with fewer fractures and less weight gain, likely due to lower cumulative steroid doses, while achieving similar long-term disease control.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

Prednisone plus methotrexate for polymyalgia rheumatica: a randomized, double-blind, placebo-controlled trial.

Author: CaporaliRoberto, CimminoMarco A, FerraccioliGianfranco, GerliRoberto, KlersyCatherine, SalvaraniCarlo, MontecuccoCarlomaurizio,

Shorter prednisone treatment
Steroid sparing

Prednisone plus methotrexate was associated with shorter prednisone treatment and steroid sparing in patients with polymyalgia rheumatica. It may be a useful alternative for patients at high risk for steroid-related toxicity.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Infliximab plus prednisone or placebo plus prednisone for the initial treatment of polymyalgia rheumatica: a randomized trial.

Author: SalvaraniCarlo, MacchioniPierLuigi, ManziniCarlo, PaolazziGiuseppe, TrottaAldo, ManganelliPaolo, CimminoMarco, GerliRoberto, CatanosoMaria Grazia, BoiardiLuigi, CantiniFabrizio, KlersyCatherine, HunderGene G

Harm

Adding infliximab to prednisone for treating newly diagnosed polymyalgia rheumatica did not improve the outcome compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Treatment of polymyalgia rheumatica: a systematic review.

Author: Hernández-RodríguezJosé, CidMaria C, López-SotoAlfons, Espigol-FrigoléGeorgina, BoschXavier

PMR treatment

This review examined the research on treating polymyalgia rheumatica (PMR), focusing on the best type of corticosteroids, starting doses, and how to reduce doses over time, as well as other medications used to reduce corticosteroid use. The primary treatment for PMR is low-dose corticosteroids.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Increased muscle interstitial levels of inflammatory cytokines in polymyalgia rheumatica.

Author: KreinerFrederik, LangbergHenning, GalboHenrik

This study investigates the cause of muscle pain in polymyalgia rheumatica (PMR), a condition that causes muscle aches and inflammation. While it's currently believed that the pain originates from inflammation in joint tissues, the study aims to examine inflammation within the muscles themselves by measuring levels of inflammatory substances (cytokines) before and after treatment with prednisolone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Polymyalgia Rheumatica (PMR) Special Interest Group at OMERACT 11: outcomes of importance for patients with PMR.

Author: MackieSarah L, AratSeher, da SilvaJose, DuarteCatia, HallidaySue, HughesRod, MorrisMarianne, PeaseColin T, ShermanJeffrey W, SimonLee S, WalshMaggie, WesthovensRené, ZakoutSamy, KirwanJohn R

Improved function
Pain relief
Reduced stiffness

This study aimed to develop a core outcome set for clinical research in polymyalgia rheumatica (PMR). Findings suggest that pain visual analog scores (VAS) are a suitable primary outcome measure for assessing response to initial therapy, with pain, stiffness, fatigue, and sleep disturbance being commonly reported symptoms. Further validation is needed to develop a comprehensive core outcome set, and consideration should be given to potential confounding factors like comorbidity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Prednisone compared to methylprednisolone in the polymyalgia rheumatica treatment.

Author: ViapianaOmbretta, GattiDavide, TropliniSonila, AdamiSilvano, FracassiElena, IdolazziLuca, RossiniMaurizio

Similar therapeutic effect
Delayed response to PN

Glucocorticoids (GLs) are the primary treatment for polymyalgia rheumatica (PMR), but some patients require high doses or respond better to specific types of GLs. This study compared the effectiveness of prednisone (PN) and methylprednisolone (MPONE) in PMR patients, finding that MPONE may offer faster symptom relief and a shorter time to achieve remission.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

13.

Current evidence for therapeutic interventions and prognostic factors in polymyalgia rheumatica: a systematic literature review informing the 2015 European League Against Rheumatism/American College of Rheumatology recommendations for the management of polymyalgia rheumatica.

Author: DejacoChristian, SinghYogesh P, PerelPablo, HutchingsAndrew, CamellinoDario, MackieSarah, MattesonEric L, DasguptaBhaskar

PMR treatment

This review examined the evidence for treatments and risk factors for polymyalgia rheumatica (PMR). While there's limited research on initial corticosteroid doses, a higher starting dose (20 mg) was associated with a lower risk of relapse but more side effects. Intramuscular methylprednisolone was as effective as oral corticosteroids with fewer side effects. Methotrexate may help reduce the need for corticosteroids and relapse rates. Women, patients with high inflammation levels, and those with joint pain outside the spine are at higher risk of relapse. More research is needed on effective treatments and risk factors for PMR.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

14.

Comorbidity in polymyalgia rheumatica.

Author: ChatzigeorgiouC, MackieS L

Improved PMR treatment

Polymyalgia rheumatica (PMR) is common in older people and is often accompanied by comorbidities, which may affect treatment decisions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

Comorbidities in polymyalgia rheumatica: a systematic review.

Author: PartingtonRichard, HelliwellToby, MullerSara, Abdul SultanAlyshah, MallenChristian

This study systematically reviews the literature on comorbidities associated with polymyalgia rheumatica (PMR), a common inflammatory rheumatological condition affecting older people.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

16.

Long-term glucocorticoid treatment and high relapse rate remain unresolved issues in the real-life management of polymyalgia rheumatica: a systematic literature review and meta-analysis.

Author: FlorisAlberto, PigaMatteo, ChessaElisabetta, CongiaMattia, ErreGian Luca, AngioniMaria Maddalena, MathieuAlessandro, CauliAlberto

GC treatment for PMR

This systematic review and meta-analysis examined the prevalence and predictors of long-term glucocorticoid (GC) treatment and disease relapses in the real-life management of polymyalgia rheumatica (PMR). The study found that a high proportion of patients continue to take GCs for extended periods, and relapses are common. However, further research is needed to identify factors that contribute to prolonged GC use and to develop more effective steroid-sparing strategies.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Tocilizumab in patients with new onset polymyalgia rheumatica (PMR-SPARE): a phase 2/3 randomised controlled trial.

Author: BonelliMichael, RadnerHelga, KerschbaumerAndreas, MrakDaniel, DurechovaMartina, StiegerJutta, HusicRusmir, MandlPeter, SmolenJosef S, DejacoChristian, AletahaDaniel

Glucocorticoid-free remission
Reduced relapse time
Serious adverse events

Tocilizumab was superior to placebo in achieving sustained glucocorticoid-free remission, delaying time to relapse, and reducing cumulative glucocorticoid dose in patients with new onset polymyalgia rheumatica undergoing rapid glucocorticoid tapering.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effect of Tocilizumab on Disease Activity in Patients With Active Polymyalgia Rheumatica Receiving Glucocorticoid Therapy: A Randomized Clinical Trial.

Author: Devauchelle-PensecValérie, Carvajal-AlegriaGuillermo, DernisEmmanuelle, RichezChristophe, TruchetetMarie-Elise, WendlingDaniel, ToussirotEric, PerdrigerAleth, GottenbergJacques-Eric, FeltenRenaud, FautrelBruno Jean, ChicheLaurent, HilliquinPascal, Le HenaffCatherine, DervieuxBenjamin, DirezGuillaume, Chary-ValckenaereIsabelle, CornecDivi, GuellecDewi, MarhadourThierry, NowakEmmanuel, SarauxAlain

Reduced disease activity
Infections

This double-blind, placebo-controlled randomized clinical trial of 101 patients with active polymyalgia rheumatica despite prednisone therapy found that tocilizumab, compared with placebo, resulted in a significantly greater percentage of patients with reduced prednisone requirements.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

19.

Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial.

Author: MaXinlei, YangFan, WuJinzhi, XuBei, JiangMengdi, SunYiduo, SunChuanying, YuYe, XuDanyi, XiaoLanlan, RenChunyun, ChenChunyan, YeZi, LiangJunyu, LinJin, ChenWeiqian

PMR treatment

Polymyalgia rheumatica (PMR) is a common inflammatory condition that affects older adults. While steroids are the main treatment, they can have side effects. We need to understand what causes PMR and find other treatments that can reduce the need for steroids. This study will examine the characteristics of PMR and investigate the effectiveness and safety of a medication called tofacitinib, which blocks a specific enzyme, in people with PMR.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

Sarilumab for Relapse of Polymyalgia Rheumatica during Glucocorticoid Taper.

Author: SpieraRobert F, UnizonySebastian, WarringtonKenneth J, SloaneJennifer, GiannelouAngeliki, NivensMichael C, AkinladeBolanle, WongWanling, BhoreRafia, LinYong, ButtgereitFrank, Devauchelle-PensecValerie, Rubbert-RothAndrea, YancopoulosGeorge D, MarracheFrederic, PatelNaimish, DasguptaBhaskar,

Polymyalgia rheumatica treatment

This study examines the potential role of sarilumab, a human monoclonal antibody that blocks the interleukin-6 pathway, in treating polymyalgia rheumatica (PMR). A significant proportion of patients with PMR experience relapses during glucocorticoid tapering.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.