Reinforcing, subject-rated, performance and physiological effects of methylphenidate and d-amphetamine in stimulant abusing humans.

Author: FillmoreMark T, GlaserPaul E A, RushCraig R, StoopsWilliam W

Paper Details 
Original Abstract of the Article :
Methylphenidate has potential for abuse because it produces behavioural effects similar to those observed with other abused stimulants, such as d-amphetamine and cocaine. The aim of this study was to further characterize the abuse potential of oral methylphenidate relative to oral d-amphetamine. Ten...See full text at original site
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引用元:
https://doi.org/10.1177/0269881104047281

データ提供:米国国立医学図書館(NLM)

Reinforcing, Subject-Rated, Performance and Physiological Effects of Methylphenidate and d-Amphetamine in Stimulant Abusing Humans

Methylphenidate, a medication commonly used to treat attention-deficit/hyperactivity disorder (ADHD), has a potential for abuse. This study, like a scientific expedition into the complex landscape of drug abuse, investigates the reinforcing effects of methylphenidate and d-amphetamine, two stimulants with the potential for abuse, in individuals with a history of stimulant abuse. The researchers aimed to understand the similarities and differences between the effects of these drugs, uncovering the potential for abuse and the underlying mechanisms of their actions.

Exploring the Reinforcing Effects of Stimulants: A Desert Oasis with Hidden Dangers

The study found that both methylphenidate and d-amphetamine produced reinforcing effects, suggesting that both drugs have a potential for abuse. This finding highlights the need for careful monitoring of individuals prescribed these medications, especially those with a history of substance abuse. The study also revealed that the effects of methylphenidate and d-amphetamine were not identical, suggesting that different mechanisms may underlie their reinforcing effects. This knowledge, like a map leading us through a complex desert terrain, can inform future research into the development of less-abusable medications for ADHD.

Navigating the Risks of Stimulant Medications

The study underscores the importance of understanding the potential for abuse of stimulant medications, particularly in individuals with a history of substance abuse. It highlights the need for careful monitoring and a personalized approach to treatment, ensuring that patients receive the appropriate care while minimizing the risk of abuse. The desert of drug abuse is vast and unpredictable, and navigating this landscape requires vigilance and a careful understanding of the risks involved.

Dr.Camel's Conclusion

This research, like a vigilant camel guarding a precious oasis, highlights the potential for abuse of stimulant medications. The study reveals the reinforcing effects of methylphenidate and d-amphetamine and underscores the importance of careful monitoring and treatment strategies to mitigate the risk of abuse. Navigating the desert of drug abuse requires a thoughtful and cautious approach, ensuring that patients receive the appropriate care while minimizing the potential for harm.

Date :
  1. Date Completed 2005-04-12
  2. Date Revised 2022-03-16
Further Info :

Pubmed ID

15582920

DOI: Digital Object Identifier

10.1177/0269881104047281

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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