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Beans, roots and leaves: a brief history of the pharmacological therapy of parkinsonism.

Author: FoleyPaul

Historical ArticleA research paper that analyzes past events and developments using primary sources and examines them from a historical perspective.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This article examines the history of treatments for Parkinson's disease. Early treatments focused on plant alkaloids, then shifted to synthetic drugs. L-DOPA therapy was a major breakthrough in treating the disease. Current research is focusing on neuroprotective treatments to prevent or slow the progression of the disease.
Paper Details　
Original Abstract of the Article :
It is not clear whether parkinsonism as it is now defined - a progressive neurodegenerative disorder of the basal ganglia characterized by sharply reduced striatal dopamine levels - has always affected a significant minority of aged persons, but suggestive evidence to this effect is reviewed. THe ma...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/15641199

データ提供：米国国立医学図書館（NLM）

The History of Parkinsonism Treatment: From Plants to L-DOPA

Parkinsonism is a debilitating neurological disorder, and the search for effective treatments has been ongoing for centuries. This comprehensive historical review traces the evolution of parkinsonism therapy, highlighting the various approaches that have been employed over time. The author details the use of plant alkaloids, the development of synthetic antiparkinsonian agents, and the groundbreaking discovery of L-DOPA therapy, a landmark achievement in the field. This historical perspective provides valuable insights into the ongoing quest to improve the lives of those living with parkinsonism.

L-DOPA Therapy: A Turning Point in Parkinsonism Treatment

This historical review underscores the significance of L-DOPA therapy in the treatment of parkinsonism. The author highlights the discovery of the striatal dopamine deficit in parkinsonism and the subsequent introduction of L-DOPA therapy as a transformative moment in the field. The development of L-DOPA therapy marked a significant turning point, offering a targeted and effective approach to managing the symptoms of parkinsonism.

Parkinsonism Treatment: A Journey of Discovery and Innovation

This historical review provides a fascinating journey through the evolution of parkinsonism treatment. The author explores the various approaches that have been employed, from the use of plant alkaloids to the development of L-DOPA therapy. This historical perspective highlights the ongoing quest for improved treatments and the importance of continuous research and innovation in the field.

Dr.Camel's Conclusion

Like a desert wanderer tracing the footsteps of ancient travelers, this historical review charts the evolution of parkinsonism treatment. The author's insights into the various approaches employed over time offer a testament to the ongoing quest for improved treatments and the remarkable progress that has been made in managing this challenging condition. This review underscores the importance of continuous research and innovation in the pursuit of better therapies for those living with parkinsonism.
Date :
  1. Date Completed 2005-03-24
  2. Date Revised 2016-10-21
Further Info :

Pubmed ID

15641199

DOI: Digital Object Identifier

15641199

SNS
PICO Info
in preparation
Languages

English

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