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Double-blind, randomized, placebo-controlled study to evaluate the effects of tegaserod on gastric motor, sensory and myoelectric function in healthy volunteers.

Author: BurtonD, CamilleriM, EarnestD L, KochK, PetersonJ, RuckerM J, TalleyN J, ThomfordeG, ZinsmeisterA R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tegaserod, a selective serotonin 5-HT4 receptor agonist, decreased proximal gastric volume change after a meal but had no significant effects on gastric motor and sensory function in healthy individuals. Further studies are required in patients with disturbances of gastric motor and sensory function.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The effects of tegaserod on gastric accommodation and postprandial satiety remain unclear. AIM: To compare the effects of tegaserod 6 mg twice daily vs. placebo on gastric volumes, postprandial symptoms, gastric emptying, small bowel transit and the surface electrogastrogram in female a...See full text at original site
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引用元：
https://doi.org/10.1111/j.1365-2036.2006.03049.x

データ提供：米国国立医学図書館（NLM）

Tegaserod: Exploring the Desert of Gastric Function

The stomach is a complex and important organ, responsible for digesting our food and sending signals to the brain about our feelings of fullness. It's like a desert oasis, processing the resources we need to survive.

Tegaserod: A Quest for Understanding

This study investigated the effects of tegaserod, a medication that affects the movement and sensation of the stomach, on gastric function. It's like exploring a desert oasis, trying to understand its ecosystem and how it works. The study found that tegaserod didn't significantly affect gastric emptying, volumes, or electrical activity in healthy volunteers. It's like finding an oasis that's already thriving, with no need for intervention.

Further Research Needed

This study is a valuable contribution to our understanding of tegaserod and its effects on the stomach. It's like uncovering a new layer of information about the desert oasis. However, more research is needed to determine the effects of tegaserod in people with specific gastric problems, like those who experience delayed gastric emptying or difficulty feeling full. It's like exploring the depths of the oasis, seeking to understand its unique characteristics and how they might benefit those in need.

Dr.Camel's Conclusion

This study reminds us that the human body is a complex and fascinating system, like a vast and ever-changing desert. It's important to continue exploring the mechanisms of this system, seeking new knowledge and understanding, to better address the challenges and ailments that we face.
Date :
  1. Date Completed 2007-03-29
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

16918891

DOI: Digital Object Identifier

10.1111/j.1365-2036.2006.03049.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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