Effects of tazarotene topical: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Major Research Findings

Tegaserod, a medication that was previously used to treat irritable bowel syndrome, has been the subject of several studies investigating its effects on the gastrointestinal system. 3 examined the impact of tegaserod on gastric motor, sensory, and myoelectric function in healthy volunteers, while 4 focused on its effects on esophageal function and bolus transport. These studies revealed that tegaserod has prokinetic effects on the digestive tract. However, 2 highlights that tegaserod can cause gastrointestinal side effects, particularly diarrhea, in some individuals. 5 investigates the potential effects of tegaserod on platelet activation and aggregation, raising concerns about potential cardiovascular side effects. Lastly, 1 aimed to assess the cardiac safety profile of tegaserod and found no significant electrocardiographic effects.

Benefits and Risks

Benefit Summary

Tegaserod has been shown to improve digestive function and may be beneficial for individuals with gastrointestinal motility disorders.

Risk Summary

Tegaserod can cause gastrointestinal side effects, primarily diarrhea, and there are concerns about potential cardiovascular side effects.

Comparison between Studies

Similarities in Studies

These studies consistently demonstrate that tegaserod exerts prokinetic effects on the gastrointestinal system.

Differences in Studies

The studies focused on different aspects of the gastrointestinal system. 3 and 4 examined the effects of tegaserod on gastric and esophageal function, respectively. 2 focused on the safety profile, while 5 investigated its effects on platelet function, and 1 assessed its cardiac safety.

Consistency and Inconsistencies in Findings

While the studies consistently indicate prokinetic effects, there are inconsistencies regarding the safety of tegaserod. While 2 highlighted the gastrointestinal side effects, 1 did not detect significant electrocardiographic effects, but 5 raised concerns about potential cardiovascular side effects. This suggests that further research is needed to fully understand the safety profile of tegaserod.

Application in Real Life with Precautions

Tegaserod is no longer available for general use. This is due to concerns about its cardiovascular safety profile. However, this information may be valuable for healthcare professionals who are involved in clinical research or treating patients with specific gastrointestinal conditions.

Limitations of Current Research

The research on tegaserod has limitations, such as the small sample sizes of some studies, the focus on healthy volunteers in some cases, and the lack of long-term follow-up for potential side effects.

Directions for Future Research

Future research should focus on addressing the gaps in our understanding of tegaserod’s safety and efficacy, particularly its long-term effects and its role in specific gastrointestinal conditions.

Conclusion

Tegaserod is a medication that has been investigated for its potential benefits and risks in treating gastrointestinal motility disorders. While research has shown some prokinetic effects, concerns about cardiovascular safety have led to its withdrawal from general use. Further research is needed to better understand its safety profile and its potential benefits in specific populations.

Literature analysis of 8 papers
Positive Content
6
Neutral Content
0
Negative Content
2
Article Type
4
1
1
3
8
1.

Tegaserod, a 5-hydroxytryptamine type 4 receptor partial agonist, is devoid of electrocardiographic effects.

Author: MorganrothJoel, RüeggPeter C, Dunger-BaldaufCornelia, Appel-DingemanseSilke, BliesathHarald, LefkowitzMartin

IBS treatment
Cardiac arrhythmias

This study investigated the cardiac safety profile of tegaserod, a promotility agent for irritable bowel syndrome (IBS), by analyzing electrocardiographic data from clinical trials. The aim was to assess whether tegaserod affects cardiac repolarization, which could lead to potentially life-threatening arrhythmias.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Review article: the safety profile of tegaserod.

Author: SchoenfeldP

Diarrhea
Headache

Tegaserod is generally safe and well-tolerated for the treatment of irritable bowel syndrome with constipation. The most common side effect is diarrhea, which is usually mild and transient.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

3.

Double-blind, randomized, placebo-controlled study to evaluate the effects of tegaserod on gastric motor, sensory and myoelectric function in healthy volunteers.

Author: TalleyN J, CamilleriM, BurtonD, ThomfordeG, KochK, RuckerM J, PetersonJ, ZinsmeisterA R, EarnestD L

Reduced gastric volume change
No significant effect on gastric function

Tegaserod, a selective serotonin 5-HT4 receptor agonist, decreased proximal gastric volume change after a meal but had no significant effects on gastric motor and sensory function in healthy individuals. Further studies are required in patients with disturbances of gastric motor and sensory function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

The effects of tegaserod on oesophageal function and bolus transport in healthy volunteers: studies using concurrent high-resolution manometry and videofluoroscopy.

Author: FoxM, MenneD, StutzB, FriedM, SchwizerW

Improved peristalsis
Improved solid bolus transport

Tegaserod did not alter lower oesophageal sphincter pressure, but had significant effects on peristaltic function. This effect was associated with a non-significant trend to improved solid bolus transit.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

An Ex Vivo Study to Evaluate the Effect of Tegaserod on Platelet Activation and Aggregation.

Author: GurbelPaul A, BlidenKevin, BarnettScott D, WittCasey, ZouHeng, TantryUdaya

Irritable bowel syndrome treatment
Cardiovascular side effects
Platelet aggregation

This study aimed to assess the ex vivo effects of tegaserod, a 5-hydroxytryptamine-4 serotonin receptor agonist, on platelet aggregation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Receptor-selective retinoids for psoriasis: focus on tazarotene.

Author: WeindlGünther, RoederAlexander, Schäfer-KortingMonika, SchallerMartin, KortingHans Christian

Psoriasis treatment
Burning
Cheilitis
Dry skin
Erythema
Pruritus
Skin irritation
Teratogenicity

Topical and oral retinoids are used to treat psoriasis. Tazarotene, a topical receptor-selective retinoid, is effective for treating plaque psoriasis. Oral tazarotene is also effective for moderate to severe plaque psoriasis. The most serious side effect of oral tazarotene is teratogenicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Psoriasis (chronic plaque).

Author: NaldiLuigi, RzanyBerthold

Improved skin condition
Psoriasis treatment
Various treatment options
Side effects

This systematic review provides information on the effectiveness and safety of various treatments for chronic plaque psoriasis, including systemic drug treatments, topical drug treatments, non-drug treatments, ultraviolet light treatments, and combined treatments.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

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