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Effects of single and repeated doses of theophylline on aspects of performance, electrophysiology and subjective assessments in healthy human subjects.

Author: BartelP, BeckerP, DelportR, LotzB, UbbinkJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Theophylline, when taken in both single and repeated doses, was found to stimulate the central nervous system (CNS) in healthy adults. While single doses did not significantly affect mood, repeated doses led to unpleasant side effects. The study also found that tolerance to theophylline developed over four weeks of therapy.
Paper Details　
Original Abstract of the Article :
The effects of both single and repeated doses of theophylline were evaluated on a battery of nine performance tests, the EEG, the EMG and on subjective assessments of mood and side-effects. The subjects were 20 healthy adults who participated in both phases of this randomized, double-blind, placebo ...See full text at original site
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引用元：
https://doi.org/10.1007/BF02253594

データ提供：米国国立医学図書館（NLM）

Theophylline: A Desert Oasis or a Mirage?

The effects of theophylline on human performance, electrophysiology, and subjective assessments were investigated in this double-blind, placebo-controlled study. Researchers assessed the effects of both single and repeated doses of theophylline on a battery of performance tests, EEG, EMG, and subjective assessments of mood and side effects. The researchers found that single doses of theophylline resulted in improved performance on some cognitive tests, suggesting a potential stimulatory effect. However, with repeated doses, theophylline showed marked adverse effects, possibly related to unpleasant side effects. The study also highlighted the development of tolerance to theophylline's effects over time.

Unveiling the Desert of Theophylline's Effects: A Journey of Stimulation and Tolerance

The research reveals a complex interplay of stimulation and tolerance associated with theophylline. While single doses exhibited some positive effects on performance, repeated doses led to a significant increase in adverse effects, potentially related to unpleasant side effects. This suggests that theophylline's therapeutic effects may be accompanied by a trade-off, requiring careful monitoring to optimize benefits while minimizing potential downsides.

Navigating the Desert of Theophylline: A Balanced Approach

This research underscores the importance of balancing potential benefits with potential risks when considering theophylline as a therapeutic option. The study highlights the development of tolerance to theophylline's effects, suggesting the need for careful monitoring and personalized adjustments in dosage and treatment regimens. This research provides valuable insights for clinicians in navigating the desert of theophylline's effects, seeking to maximize its benefits while minimizing potential risks.

Dr. Camel's Conclusion

Theophylline's effects can be unpredictable, like a mirage in the desert. While it may offer a temporary boost, it can also lead to unwanted side effects. This research emphasizes the need for careful consideration and balanced approach when using this drug.

Date :
  1. Date Completed 1992-03-18
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

1738797

DOI: Digital Object Identifier

10.1007/BF02253594

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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