Molecular response to aromatase inhibitor treatment in primary breast cancer.

Author: AshworthAlan, DexterTim, DixonJ Michael, DowsettMitch, DrurySuzanne, EvansDean B, FenwickKerry, LarionovAlexey, MackayAlan, MillerWilliam R, UrruticoecheaAnder, WhiteSharon, YoungOliver

Paper Details 
Original Abstract of the Article :
Aromatase inhibitors such as anastrozole and letrozole are highly effective suppressants of estrogen synthesis in postmenopausal women and are the most effective endocrine treatments for hormone receptor positive breast cancer in such women. Little is known of the molecular effects of these agents o...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1929101/

データ提供:米国国立医学図書館(NLM)

Aromatase Inhibitors: A Key to Combating Estrogen-Fueled Breast Cancer

In the vast desert of breast cancer research, we're constantly seeking oases of knowledge to guide us. This study digs into the molecular effects of aromatase inhibitors, like anastrozole and letrozole, on human breast carcinomas in vivo. These inhibitors are like camels, diligently carrying a payload of anti-estrogen power to combat the growth of hormone receptor-positive breast cancer in postmenopausal women. The study reveals that these inhibitors are highly effective suppressants of estrogen synthesis, making them a valuable tool in the fight against this disease. This research sheds light on the molecular mechanisms behind aromatase inhibitors, helping us to better understand their effectiveness and refine their use in treating breast cancer.

Unlocking the Secrets of Aromatase Inhibitors

The researchers found that aromatase inhibitors, like anastrozole and letrozole, effectively suppress estrogen synthesis in postmenopausal women. This is a significant finding, as estrogen plays a critical role in the growth of hormone receptor-positive breast cancer. These inhibitors, like hardy camels navigating the desert, effectively block the synthesis of estrogen, ultimately hindering the growth of this type of breast cancer. The study emphasizes the importance of understanding the molecular effects of these agents in order to optimize their use in treating breast cancer.

Aromatase Inhibitors: A Promising Weapon in the Fight Against Breast Cancer

These inhibitors are like a refreshing oasis in the dry desert of breast cancer treatment. They offer a targeted approach to fighting the disease, specifically targeting the synthesis of estrogen. This is particularly important for postmenopausal women, who are more susceptible to hormone receptor-positive breast cancer. By understanding the molecular mechanisms of these inhibitors, we can refine treatment strategies and ultimately improve the lives of patients.

Dr.Camel's Conclusion

This study reveals the potent effects of aromatase inhibitors on breast cancer cells, paving the way for more effective treatment strategies. Their ability to suppress estrogen synthesis makes them a valuable weapon in the fight against this disease. As we delve deeper into the desert of molecular mechanisms, we will uncover more secrets about the potential of these inhibitors in treating breast cancer.

Date :
  1. Date Completed 2007-09-14
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

17555561

DOI: Digital Object Identifier

PMC1929101

SNS
PICO Info
in preparation
Languages

English

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