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A double-blind dose-response study of amlodipine in patients with stable angina pectoris.

Author: AlfieroR, CoccoG

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Amlodipine, a calcium channel blocker, demonstrated significant anti-anginal efficacy in 60 patients. In a 4-week double-blind study, amlodipine resulted in a significant increase in exercise time, a decrease in angina attack frequency, and a decrease in nitroglycerin consumption compared to placebo.
Paper Details　
Original Abstract of the Article :
Sixty patients (31 male, 29 female) were studied in a 4-week double-blind parallel dose-response study. Patients received amlodipine 1.25 mg (n = 12), 2.5 mg (n = 12), 5 mg (n = 12), 10 mg (n = 12) or placebo (n = 12) once a day. Anti-anginal efficacy was assessed by sequential treadmill testing 24 ...See full text at original site
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引用元：
https://doi.org/10.1093/oxfordjournals.eurheartj.a059864

データ提供：米国国立医学図書館（NLM）

A Journey Through the Desert of Angina: Exploring the Efficacy of Amlodipine

My friend, we're venturing into the challenging landscape of angina pectoris, a condition characterized by chest pain caused by reduced blood flow to the heart. This research, like a skilled camel caravan seeking relief in the desert, explores the efficacy of amlodipine, a calcium channel blocker, in treating stable angina. The authors, through a double-blind, dose-response study, discovered that amlodipine significantly improved exercise tolerance and reduced angina attack frequency in patients with stable angina. This suggests that amlodipine may be a valuable treatment option for managing this condition.

Finding a Path Through the Sands: Understanding the Benefits of Amlodipine

The authors' findings highlight the potential benefits of amlodipine for patients with stable angina. The drug's ability to improve exercise tolerance and reduce angina attack frequency indicates its effectiveness in reducing chest pain and improving overall quality of life. The study's findings underscore the importance of consulting with a healthcare professional to determine the appropriate dosage and safety of amlodipine for individual patients.

The Path to a Healthier Heart: Understanding the Implications for Cardiac Health

This research offers valuable insights for individuals with stable angina. The findings suggest that amlodipine may be an effective treatment option for managing this condition, improving exercise tolerance and reducing chest pain. However, it's crucial to remember that amlodipine is a medication and should only be used under the guidance of a healthcare professional.

Dr. Camel's Conclusion

This research, like a camel caravan seeking a safe passage through a challenging desert, provides valuable insights into the potential benefits of amlodipine for treating stable angina. By understanding the efficacy and safety of this medication, we can help individuals with angina navigate their condition with greater ease and improved quality of life.

Date :
  1. Date Completed 1991-07-16
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

1828420

DOI: Digital Object Identifier

10.1093/oxfordjournals.eurheartj.a059864

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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