Effects of amlodipine: A Synthesis of Findings from 37 Studies

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Original Abstract of the Article

Main Research Findings

Amlodipine is a calcium channel blocker used to treat high blood pressure and stable angina. A meta-analysis in 36 found that amlodipine has three times higher risk of peripheral edema compared to placebo. However, it is estimated that up to one-third of edema cases in amlodipine-treated patients are not induced by the drug itself. Amlodipine was also found to reduce the occurrence of headaches compared to placebo, especially at low to medium doses (2.5-5 mg). 16 demonstrated that amlodipine does not increase the risk of arrhythmias in patients with severe, chronic coronary artery disease who are already receiving conventional anti-ischemic therapy. 26 reported that amlodipine in combination with perindopril had a lower incidence of cardiovascular events and diabetes compared to atenolol and bendroflumethiazide. 17 showed that amlodipine significantly reduces the number of ischemic events in patients with stable angina pectoris during daily life. 35 suggests that amlodipine may alter hemorheological parameters. 19 found that amlodipine may slow down the progression of atherosclerosis. 14 reported that amlodipine had a significantly greater reduction in blood pressure than long-acting diltiazem. 8 showed that amlodipine is safe and effective for the treatment of chronic stable angina pectoris. A meta-analysis in 33 found that amlodipine significantly reduced the risk of myocardial infarction and stroke compared to other non-CCB antihypertensive therapies. 6 showed that amlodipine was comparable to hydrochlorothiazide in reducing blood pressure. 23 found that amlodipine combined with benazepril had a significantly higher blood pressure reduction compared to amlodipine monotherapy. 12 showed that amlodipine is effective and well-tolerated in patients with stable angina. 2 reported that amlodipine was more effective and tolerated compared to nifedipine in treating chronic ischemic heart disease. 28 reported that both amlodipine and telmisartan, and amlodipine and amiloride, are effective combinations for blood pressure control in hypertensive patients. 3 found that amlodipine was associated with a lower incidence of acute side effects compared to nitrendipine. 30 reported that bedtime dosing of amlodipine combined with valsartan showed the highest blood pressure control effect. 11 showed that amlodipine is comparable to hydrochlorothiazide in reducing blood pressure and is well-tolerated. 13 reported that amlodipine was associated with fewer early side effects compared to nifedipine. 4 showed that amlodipine is effective and well-tolerated in treating stable angina pectoris. 5 found that amlodipine was comparable to atenolol in reducing blood pressure, but without affecting heart rate. 7 showed that amlodipine is effective and well-tolerated in treating mild to moderate hypertension. 9 reported that amlodipine was comparable to enalapril in terms of efficacy and tolerability. 27 reported that amlodipine combined with atorvastatin was superior to monotherapy in improving vascular and metabolic effects in hypertensive patients. 21 found that amlodipine is effective in treating isolated systolic hypertension in elderly patients. 22 showed that amlodipine significantly reduces 24-hour ambulatory blood pressure in hypertensive patients. 15 showed that amlodipine was not significantly better than placebo in reducing ambulatory ischemia in patients with stable angina who are already receiving beta-blockers. 1 showed that amlodipine is effective in controlling blood pressure for the entire dosing interval with a once-daily dose. 20 found that amlodipine has a good tolerability profile in elderly hypertensives. 25 found that amlodipine combined with atorvastatin resulted in early improvements in arterial wall compliance in hypertensive patients with dyslipidemia. 37 showed that amlodipine is well tolerated and has a favorable safety profile in healthy Chinese volunteers. 32 reported that amlodipine combined with azilsartan medoxomil was well tolerated and led to meaningful additional blood pressure reductions compared with placebo plus amlodipine. 18 showed that amlodipine can improve exercise tolerance in patients with heart failure from left ventricular systolic dysfunction. 34 suggested that combining perindopril arginine and amlodipine besylate in a single pill may be a useful addition to the antihypertensive armamentarium. 29 showed that the triple combination of amlodipine, valsartan, and hydrochlorothiazide was more effective in lowering blood pressure than dual-component therapies. 24 found that amlodipine camsylate and amlodipine besylate are comparable in their effectiveness in treating hypertension in Korean adults. 10 showed that amlodipine is effective in reducing ischemia in patients with stable angina pectoris who are already receiving beta-blockers. 31 suggests that both amlodipine and S(-)-amlodipine are effective in improving vascular endothelial function in hypertensive patients.

Benefits and Risks

Benefits Summary

Amlodipine is a medication effective for treating high blood pressure and stable angina. Multiple studies have shown that amlodipine effectively lowers blood pressure and reduces the risk of myocardial infarction and stroke. 33 Amlodipine is also expected to improve exercise tolerance in patients with stable angina. 17 Additionally, amlodipine has been shown to improve endothelial function and may slow down the progression of atherosclerosis. 19 25 Furthermore, amlodipine can be used in combination with other antihypertensive medications to potentially achieve better blood pressure control. 32 28 23 Amlodipine is generally well-tolerated and considered safe for many patients. 8 9 37

Risks Summary

A possible side effect of amlodipine is peripheral edema. 36 There are also reports indicating that amlodipine may increase the risk of heart failure. 33 Amlodipine can interact with other medications, so it is crucial to consult with a doctor before taking it.

Comparison between Studies

Commonalities between Studies

Many studies have shown that amlodipine is effective in treating high blood pressure and stable angina. Additionally, most studies have reported that amlodipine is generally well-tolerated and safe.

Differences between Studies

The blood pressure reduction effect of amlodipine may be more pronounced when combined with other antihypertensive medications. 23 32 The time of day amlodipine is taken may also influence its blood pressure control effect. 30 The effectiveness of amlodipine can vary depending on individual patient characteristics and interactions with other medications.

Consistency and Discrepancies in Results

Although many studies have shown amlodipine to be effective in treating high blood pressure and stable angina, there are reports suggesting that it may increase the risk of heart failure. 33 Further research is needed to investigate this discrepancy.

Practical Implications and Precautions

It is crucial to take amlodipine as directed by your doctor. Do not stop or change the dosage without consulting your doctor. Be aware of possible side effects such as peripheral edema and heart failure. 36 33 Additionally, be mindful of potential interactions with other medications. Consult your doctor before taking amlodipine.

Limitations of Current Research

While there is a wealth of research on the effects of amlodipine, some aspects remain unclear. For example, the evidence suggesting that amlodipine increases the risk of heart failure is not yet conclusive. 33 The effectiveness of amlodipine can also vary depending on individual patient characteristics and interactions with other medications.

Future Directions for Research

Further research is needed to better understand the effects of amlodipine. Specifically, it is essential to investigate whether amlodipine indeed increases the risk of heart failure and to understand the mechanisms involved. Additionally, more detailed research is required to determine how the effects of amlodipine vary depending on individual patient characteristics and interactions with other medications.

Conclusion

Amlodipine is an effective medication for treating high blood pressure and stable angina and is considered safe for many patients. However, it is important to be aware of possible side effects such as peripheral edema and heart failure. 36 33 Consult with your doctor before taking amlodipine and adhere to their instructions for proper use.

Keywords
Benefit Keywords
Long duration
Once-daily dosing
Reduce blood pressure
1
Improved tolerability
Reduced angina
Reduced ischemia
Single daily dose
2
Blood pressure control
Few side effects
Improved patient compliance
3
Angina treatment
4
No effect on heart rate
Reduces blood pressure
Well tolerated
5
Reduces blood pressure
Well tolerated
6
Effective antihypertensive
Lower blood pressure
Well tolerated
7
Effective antianginal
Increased exercise tolerance
Reduced ST-segment depression
Reduced anginal episodes
Reduced nitroglycerin usage
Safe for long-term use
8
Hypertension treatment
Quality of life maintenance
9
Angina treatment
Ischemia treatment
10
Blood pressure control
11
Treats angina
12
Hypertension treatment
13
Reduced blood pressure
14
Blood pressure reduction
15
Angina Relief
No Proarrhythmia
16
Anti-ischemic effects
17
Improved exercise tolerance
Improved left ventricular function
Improved quality of life
Safe in heart failure
18
Antianginal
Antiatherogenic
Antihypertensive
May prevent early atherosclerosis
Stabilize carotid intima media thickness
19
Hypertension control
20
Reduced blood pressure
21
Blood pressure reduction
22
Blood pressure reduction
23
Hypertension treatment
24
Reduce cardiovascular events
25
Lower blood pressure
26
Adiponectin increase
Endothelial function improvement
Insulin sensitivity increase
27
Blood pressure control
Reduced cardiovascular events
28
Blood pressure reduction
29
Blood pressure control
30
Vascular endothelial function
31
BP reduction
32
Reduced cardiovascular events
Reduced mortality
33
Blood pressure lowering
Cardiovascular endpoint reduction
34
Antihypertensive effect
35
CAD treatment
Hypertension treatment
36
Bioequivalent amlodipine
37
Risk Keywords
Flushing
Headache
Tachycardia
3
Side effects
4
Side effects
6
Ankle edema
7
Increased cholesterol
11
Flushing
Headache
13
Autonomic modulation
15
Angina
Cardiovascular events
Mortality may be increased by short-acting agents
19
Side effects
20
Antihypertensive side effects
21
Pedal edema
23
Adverse cardiovascular outcomes
Diabetes
26
None mentioned
27
Edema
32
Increased heart failure
33
Heart failure
34
Edema
35
Headache
Peripheral edema
36
Literature analysis of 37 papers
Positive Content
36
Neutral Content
0
Negative Content
1
Article Type
34
3
1
1
37
1.

Intra-arterial monitoring of the antihypertensive effects of once-daily amlodipine.

Author: BroadhurstP, HeberM E, BrigdenG, al-KhawajaI, RafteryE B

Long duration
Once-daily dosing
Reduce blood pressure

This study evaluated the antihypertensive effect of amlodipine, a calcium channel blocker, using ambulatory blood pressure monitoring. The drug effectively controlled blood pressure for the entire dosing interval with a once-daily dose, demonstrating its suitability for this regimen.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Amlodipine versus nifedipine retard in the treatment of chronic ischemic heart disease.

Author: CircoA, ScaccianoceG, PlataniaF, CastelliD, CardilloR, MangiameliS

Improved tolerability
Reduced angina
Reduced ischemia
Single daily dose

A study of 29 patients with chronic ischemic heart disease compared the effectiveness of amlodipine (a long-acting calcium channel blocker) and nifedipine (a short-acting calcium channel blocker). Both drugs significantly improved exercise tolerance, reduced angina episodes, and improved heart function. Amlodipine was more effective in delaying the onset of ST-segment deviation and achieving a longer duration of exercise compared to nifedipine. Amlodipine also had fewer side effects than nifedipine, possibly due to its longer duration of action and slower peak effect. The study concluded that amlodipine was as effective as nifedipine in reducing ischemia, but was better tolerated and easier to take due to its once-daily dosage.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

Amlodipine compared to nitrendipine in hypertensive patients: the effects on toleration in relationship to the onset of action.

Author: WaeberB, BorgesE T, ChristelerP, Guillaume-GentilM, HollensteinU, MannhartM

Blood pressure control
Few side effects
Improved patient compliance
Flushing
Headache
Tachycardia

Amlodipine and nitrendipine, both calcium antagonists, are effective in lowering blood pressure in patients with mild to moderate essential hypertension. While they are therapeutically equivalent, amlodipine has a slower onset of action, resulting in fewer acute side effects and potentially better patient compliance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

4.

A double-blind dose-response study of amlodipine in patients with stable angina pectoris.

Author: CoccoG, AlfieroR

Angina treatment
Side effects

Amlodipine, a calcium channel blocker, demonstrated significant anti-anginal efficacy in 60 patients. In a 4-week double-blind study, amlodipine resulted in a significant increase in exercise time, a decrease in angina attack frequency, and a decrease in nitroglycerin consumption compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Multicenter placebo-controlled comparison of amlodipine and atenolol in mild to moderate hypertension.

Author: de BruijnB, CoccoG, TylerH M

No effect on heart rate
Reduces blood pressure
Well tolerated

Amlodipine and atenolol were both effective in lowering blood pressure in patients with mild to moderate hypertension. Amlodipine did not affect heart rate, while atenolol did. Both drugs were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

6.

Long-term open evaluation of amlodipine versus hydrochlorothiazide in patients with essential hypertension.

Author: RofmanB A

Reduces blood pressure
Well tolerated
Side effects

Amlodipine was as effective as hydrochlorothiazide in lowering blood pressure in 139 patients with hypertension. Amlodipine was associated with a higher incidence of side effects, but both drugs were well-tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Once daily amlodipine in the treatment of mild to moderate hypertension.

Author: WebsterJ, RobbO J, JeffersT A, ScottA K, PetrieJ C, TowlerH M

Effective antihypertensive
Lower blood pressure
Well tolerated
Ankle edema

Amlodipine, a calcium channel blocker, demonstrated significant blood pressure reduction in patients with mild to moderate hypertension compared to placebo. The average reduction was 16/12 mmHg supine and 14/4 mmHg standing. The effect was reversible with the discontinuation of amlodipine, and the drug was generally well-tolerated, with only a few patients experiencing minor ankle edema.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

8.

Clinical safety and efficacy of once-a-day amlodipine for chronic stable angina pectoris.

Author: GlasserS P, WestT W

Effective antianginal
Increased exercise tolerance
Reduced ST-segment depression
Reduced anginal episodes
Reduced nitroglycerin usage
Safe for long-term use

Amlodipine, a calcium channel blocker, showed both antianginal and antiischemic effects in patients with chronic stable angina pectoris. It significantly reduced anginal episodes and nitroglycerin usage. Amlodipine also improved exercise tolerance and reduced ST-segment depression during exercise tests. The drug was well tolerated and no patient withdrawals resulted from amlodipine-related adverse events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

A double-blind, long-term, comparative study on quality of life, safety, and efficacy during treatment with amlodipine or enalapril in mild or moderate hypertensive patients: a multicenter study.

Author: OmvikP, ThaulowE, HerlandO B, EideI, MidhaR, TurnerR R

Hypertension treatment
Quality of life maintenance

Amlodipine and enalapril were both effective and well-tolerated in 461 patients with mild or moderate hypertension. Both drugs lowered blood pressure, maintained quality of life, and had few adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

10.

Pharmacokinetics and additional anti-ischaemic effectiveness of amlodipine, a once-daily calcium antagonist, during acute and long-term therapy of stable angina pectoris in patients pre-treated with a beta-blocker.

Author: LehmannG, ReinigerG, BeyerleA, RudolphW

Angina treatment
Ischemia treatment

Amlodipine, a calcium channel blocker, was evaluated for its anti-ischaemic and anti-anginal efficacy in 14 patients with stable angina pectoris. Amlodipine significantly reduced ST segment depression and increased ischaemia-free workload capacity compared to placebo, demonstrating its effectiveness in reducing angina symptoms and improving exercise tolerance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Double-blind comparison of amlodipine and hydrochlorothiazide in patients with mild to moderate hypertension.

Author: RamC V, AmesR P, ApplegateW B, BurrisJ F, DavidovM E, MroczekW J

Blood pressure control
Increased cholesterol

This study compared the effectiveness of amlodipine and hydrochlorothiazide (HCTZ) in controlling blood pressure in patients with hypertension. Amlodipine was found to be a more metabolically neutral option, while HCTZ led to increased cholesterol levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Amlodipine once a day in stable angina: double-blind crossover comparison with placebo.

Author: DeedwaniaP C, CheitlinM D, DasS K, PoolP E, SinghJ B, PasternakR C

Treats angina

Amlodipine, a dihydropyridine calcium antagonist, has a long half-life and high bioavailability, allowing for once-daily administration. It is effective in treating chronic stable angina and vasospastic angina, with efficacy comparable to beta blockers and other calcium antagonists. Amlodipine has minimal effects on heart rate and contractility and does not cause tolerance.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Early side-effects of antihypertensive therapy: comparison of amlodipine and nifedipine retard.

Author: BremnerA D, FellP J, HosieJ, JamesI G, SaulP A, TaylorS H

Hypertension treatment
Flushing
Headache

Amlodipine and nifedipine retard were equally effective in treating mild hypertension in 97 patients. However, amlodipine was associated with significantly fewer side effects, such as headache and flushing, during the first 14 days of treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Comparison of amlodipine and long-acting diltiazem in the treatment of mild or moderate hypertension.

Author: HorwitzL D, WeinbergerH D, CleggL

Reduced blood pressure

Amlodipine was found to be more effective than diltiazem in reducing systolic and diastolic blood pressure in 123 patients with diastolic blood pressures ranging from 95 to 114 mm Hg before treatment. Both drugs were well-tolerated and reduced blood pressures consistently over the 10-week test period.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

15.

Amlodipine in patients with stable angina pectoris treated with beta-blockers. Double-blind comparison with placebo.

Author: RossinenJ, PartanenJ, NieminenM S

Blood pressure reduction
Autonomic modulation

Amlodipine (AML) did not significantly improve anti-ischemic effects on coronary artery disease (CAD) patients already treated with beta-blockers. Blood pressure was reduced by AML and the total variability and very low frequency component of heart rate were reduced.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

16.

Analysis of arrhythmias in the Circadian Antiischemia Program in Europe (CAPE) study.

Author: LichtlenP R, FisherL D

Angina Relief
No Proarrhythmia

Adding the calcium channel blocker amlodipine to conventional treatment in patients with long-standing coronary artery disease did not show any proarrhythmic effects, even in patients receiving beta-blockers and nitrates.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Anti-ischemic effects of amlodipine in patients with stable angina pectoris and myocardial ischemia during daily life. Amlodipine Study Group.

Author: DeedwaniaP C

Anti-ischemic effects

Amlodipine therapy resulted in a marked decrease in the overall mean number of ischemic events and the average number of transient ischemic episodes.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

Effects of amlodipine on exercise tolerance, quality of life, and left ventricular function in patients with heart failure from left ventricular systolic dysfunction.

Author: UdelsonJ E, DeAbateC A, BerkM, NeubergG, PackerM, VijayN K, GorwittJ, SmithW B, KukinM L, LeJemtelT, LevineT B, KonstamM A

Improved exercise tolerance
Improved left ventricular function
Improved quality of life
Safe in heart failure

Amlodipine, a long-acting calcium channel blocker, is effective and safe for treating heart failure. It improved exercise capacity and quality of life in patients with heart failure and left ventricular systolic dysfunction.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

[Effects of calcium antagonists on atherosclerosis progression and intima media thickness].

Author: ZannadF

Antianginal
Antiatherogenic
Antihypertensive
May prevent early atherosclerosis
Stabilize carotid intima media thickness
Angina
Cardiovascular events
Mortality may be increased by short-acting agents

Calcium antagonists are a first-choice treatment for hypertension and angina. While some short-acting calcium antagonists may increase mortality, long-acting calcium antagonists, such as amlodipine, may have protective effects against atherosclerosis. Amlodipine was found to stabilize carotid intima media thickness, suggesting that it may be beneficial in preventing ischaemic events.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

20.

Tolerability of long-term treatment with lercanidipine versus amlodipine and lacidipine in elderly hypertensives.

Author: LeonettiGastone, MagnaniBruno, PessinaAchille Cesare, RappelliAlessandro, TrimarcoBruno, ZanchettiAlberto,

Hypertension control
Side effects

This trial compared the tolerability of lercanidipine, a calcium antagonist, to two other calcium antagonists (amlodipine and lacidipine) in elderly hypertensive patients. The study aimed to evaluate the side effects associated with these antihypertensive drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

21.

A randomized, double-blind, active-controlled, parallel-group comparison of valsartan and amlodipine in the treatment of isolated systolic hypertension in elderly patients: the Val-Syst study.

Author: MalaccoEttore, VarìNatale, CapuanoVincenzo, SpagnuoloVitaliano, BorgninoCarlo, PalatiniPaolo,

Reduced blood pressure
Antihypertensive side effects

This study compares the antihypertensive efficacy and safety of valsartan, an angiotensin II receptor blocker, and amlodipine besylate, a calcium channel blocker. While both drugs exhibit dose-related antihypertensive efficacy, amlodipine besylate is associated with possible dose-limiting adverse effects, particularly peripheral edema, whereas valsartan exhibits minimal dose-limiting adverse effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Effect of amlodipine on 24-hour ambulatory blood pressure in hypertensive patients.

Author: MroczekW J, BurrisJ F, AllenbyK S

Blood pressure reduction

This study found that amlodipine significantly reduced ambulatory blood pressure in hypertensive patients without causing reflex tachycardia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

23.

The effects of high-dose amlodipine/benazepril combination therapies on blood pressure reduction in patients not adequately controlled with amlodipine monotherapy.

Author: ChrysantSteven G, SugimotoDaniel H, LefkowitzMarty, SalkoThomas, KhanMahmudul, AroraVipin, ShiVictor

Blood pressure reduction
Pedal edema

Amlodipine/benazepril combinations were well tolerated and significantly reduced blood pressure compared to amlodipine monotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

Results of a phase III, 8-week, multicenter, prospective, randomized, double-blind, parallel-group clinical trial to assess the effects of amlodipine camsylate versus amlodipine besylate in Korean adults with mild to moderate hypertension.

Author: KimSang-Hyun, KimYoung-Dae, LimDo-Sun, YoonMyeong-Ho, AhnYoung-Keun, OnYoung-Keun, LeeJe-Won, KimIn-Jae, ParkJung-Bae, KimJae-Joong, ChungWook-Sung, YangJu-Young, SeoHong-Seok, ShinEak-Kyun, KimHyo-Soo,

Hypertension treatment

Amlodipine camsylate, a newer formulation, showed similar effectiveness to amlodipine besylate in lowering blood pressure in patients with hypertension.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

25.

Coadministered amlodipine and atorvastatin produces early improvements in arterial wall compliance in hypertensive patients with dyslipidemia.

Author: CohnJay N, WilsonDaniel J, NeutelJoel, HoustonMark, WeinbergerMyron H, GrimmRichard, SmithDavid H G, SunWilliam

Reduce cardiovascular events

Co-administered amlodipine and atorvastatin improved arterial compliance compared to either therapy alone or placebo, highlighting the vascular benefits of combination therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Distinct vascular and metabolic effects of different classes of anti-hypertensive drugs.

Author: KohKwang Kon, QuonMichael J, HanSeung Hwan, LeeYonghee, KimSoo Jin, KohYesl, ShinEak Kyun

Lower blood pressure
Adverse cardiovascular outcomes
Diabetes

The ASCOT-BPLA study found that amlodipine+perindopril was associated with a lower incidence of adverse cardiovascular outcomes and diabetes compared to atenolol+bendroflumethiazide. This difference is not explained by blood pressure changes alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

27.

Additive beneficial effects of atorvastatin combined with amlodipine in patients with mild-to-moderate hypertension.

Author: KohKwang Kon, QuonMichael J, HanSeung Hwan, LeeYonghee, ParkJeong Beom, KimSoo Jin, KohYesl, ShinEak Kyun

Adiponectin increase
Endothelial function improvement
Insulin sensitivity increase
None mentioned

Atorvastatin combined with amlodipine improved endothelial function, increased adiponectin levels, and improved insulin sensitivity to a greater extent than monotherapy with either drug in hypertensive patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., IntramuralFunding provided by the NIH for research projects within the NIH.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

[Effects of amlodipine plus telmisartan or amlodipine plus amiloride regimen on blood pressure control in hypertensive patients: preliminary report of Chinese Hypertension Intervention Efficacy (CHIEF) trial].

Author: WangWen, MaLi-yuan, LiuMing-bo, DengQing, ZhangYu-qing, LiWei, ZhuDing-liang, LinShu-guang, HuangJun, LiuLi-sheng,

Blood pressure control
Reduced cardiovascular events

Amlodipine-based antihypertensive combination regimens achieved satisfactory blood pressure control rates in patients with essential hypertension. In a multi-center, randomized, controlled trial, both amlodipine plus diuretics and amlodipine plus telmisartan resulted in similar blood pressure control rates (72.1% and 72.6%, respectively).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : Chinese

29.

Amlodipine/valsartan/hydrochlorothiazide triple combination therapy in moderate/severe hypertension: Secondary analyses evaluating efficacy and safety.

Author: CalhounDavid A, CrikelairNora A, YenJoseph, GlazerRobert D

Blood pressure reduction

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

30.

Chronotherapy with valsartan/amlodipine fixed combination: improved blood pressure control of essential hypertension with bedtime dosing.

Author: HermidaRamón C, AyalaDiana E, FontaoMaría J, MojónArtemio, FernándezJosé R

Blood pressure control

Combining valsartan and amlodipine, with both medications administered at bedtime, provides the most effective blood pressure control for the entire 24 hours compared to other dosing schedules.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

31.

The effects of amlodipine and S(-)-amlodipine on vascular endothelial function in patients with hypertension.

Author: HeYuquan, SiDaoyuan, YangChunyan, NiLujia, LiBing, DingMei, YangPing

Vascular endothelial function

S(-)-amlodipine, an enantiomer of amlodipine, showed similar effects on vascular endothelial function in hypertensive patients compared to amlodipine. This study further investigated the underlying mechanisms of action in cell culture.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Effects of combining azilsartan medoxomil with amlodipine in patients with stage 2 hypertension.

Author: WeberMichael A, WhiteWilliam B, SicaDomenic, BakrisGeorge L, CaoCharlie, RobertsAndrew, KupferStuart

BP reduction
Edema

The study found that coadministration of azilsartan medoxomil with amlodipine was well tolerated and led to meaningful additional blood pressure (BP) reductions compared with placebo plus amlodipine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

33.

Amlodipine and cardiovascular outcomes in hypertensive patients: meta-analysis comparing amlodipine-based versus other antihypertensive therapy.

Author: LeeSeung-Ah, ChoiHong-Mi, ParkHye-Jin, KoSu-Kyoung, LeeHae-Young

Reduced cardiovascular events
Reduced mortality
Increased heart failure

Amlodipine reduced the risk of total cardiovascular events as well as all-cause mortality compared with non-CCB-based regimens.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

34.

Rationale for a single-pill combination of perindopril arginine and amlodipine besylate.

Author: ElliottWilliam J

Blood pressure lowering
Cardiovascular endpoint reduction
Heart failure

A systematic review of 86 clinical trials involving perindopril, amlodipine, or other antihypertensive drugs showed that amlodipine was associated with a significant 24% increase in heart failure, but a significant decrease in cardiovascular events. Perindopril was associated with a significant reduction in all six cardiovascular endpoints.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Amlodipine alters hemorheological parameters: Increased efficacy at the cost of edema?

Author: RavindraR P, ArunkumarS, PuniyaniR R, PadgaonkarK, VadiveluRamalingam, SharmaRajeev, PanickerGopi, LokhandwalaYash

Antihypertensive effect
Edema

This study reviewed the literature on the side effect of edema associated with calcium channel blockers, specifically focusing on amlodipine. While the hemodilutory property of amlodipine may contribute to its antihypertensive action, further research is needed to understand the mechanisms behind the persistent edema side effect.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

36.

Peripheral edema and headache associated with amlodipine treatment: a meta-analysis of randomized, placebo-controlled trials.

Author: VukadinovićDavor, ScholzSean S, MesserliFranz H, WeberMichael A, WilliamsBryan, BöhmMichael, MahfoudFelix

CAD treatment
Hypertension treatment
Headache
Peripheral edema

Amlodipine treatment was associated with a three-fold higher risk of peripheral edema compared to placebo.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

37.

Evaluation of pharmacokinetics and safety with bioequivalence of Amlodipine in healthy Chinese volunteers: Bioequivalence Study Findings.

Author: WangTongtong, WangYannan, LinSisi, FangLu, LouSai, ZhaoDi, ZhuJingjing, YangQigang, WangYing

Bioequivalent amlodipine

Amlodipine is well tolerated and has a favorable safety profile. The bioequivalence is achieved under fasting and fed conditions, supporting the demonstration of biosimilarity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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