Additive beneficial effects of atorvastatin combined with amlodipine in patients with mild-to-moderate hypertension.

Author: HanSeung Hwan, KimSoo Jin, KohKwang Kon, KohYesl, LeeYonghee, ParkJeong Beom, QuonMichael J, ShinEak Kyun

Paper Details 
Original Abstract of the Article :
BACKGROUND: We hypothesized that atorvastatin combined with amlodipine has additive beneficial vascular and metabolic effects that are superior to monotherapy in patients with hypertension. METHODS: Forty-two patients were given atorvastatin 20mg/day and placebo, atorvastatin 20mg/day and amlodipin...See full text at original site
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引用元:
https://doi.org/10.1016/j.ijcard.2009.07.002

データ提供:米国国立医学図書館(NLM)

The Power of Combination Therapy: Atorvastatin and Amlodipine for Hypertension

Hypertension, a common condition affecting millions worldwide, often requires a combination of medications to effectively manage blood pressure. This research delves into the potential benefits of combining atorvastatin, a cholesterol-lowering drug, with amlodipine, a calcium channel blocker, for the treatment of mild-to-moderate hypertension.

Beyond Blood Pressure Control: A Multifaceted Approach

The authors, like meticulous gardeners tending to a flourishing garden, meticulously examine the combined effects of atorvastatin and amlodipine on blood pressure, vascular function, and metabolic parameters. The study reveals that this combination therapy, much like a well-balanced ecosystem, offers a multifaceted approach to managing hypertension, going beyond simple blood pressure reduction. This research highlights the potential for synergistic benefits when combining medications to optimize treatment outcomes.

Optimizing Cardiovascular Health

The study's findings suggest that combining atorvastatin and amlodipine, much like a symphony blending different instruments, may lead to improved cardiovascular health in hypertensive patients. The authors' meticulous analysis highlights the potential for this combination therapy to not only control blood pressure but also enhance endothelial function, increase adiponectin levels, and improve insulin sensitivity. This research, like a cool oasis in a hot desert, offers a promising avenue for improving cardiovascular health in patients with hypertension.

Dr.Camel's Conclusion

This research provides compelling evidence for the benefits of combining atorvastatin and amlodipine in managing mild-to-moderate hypertension. The authors' meticulous analysis highlights the potential for this combination therapy to not only control blood pressure but also improve vascular function and metabolic parameters. This study, like a caravan navigating a challenging desert, emphasizes the importance of considering multi-faceted approaches to optimize cardiovascular health in hypertensive patients.

Date :
  1. Date Completed 2011-05-09
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

19651449

DOI: Digital Object Identifier

10.1016/j.ijcard.2009.07.002

SNS
PICO Info
in preparation
Languages

English

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