Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial.

Author: AkreF, BrattJ, ChatzidionysiouA, CösterL, DackhammarC, ErnestamS, ForslindK, GeborekP, HellströmH, LjungL, OdingR, PeterssonI F, TelemanA, TheanderJ, ThörnerA, WaltbrandE, WörnertM, ZickertA, van VollenhovenR F

Paper Details 
Original Abstract of the Article :
New treatment strategies for early rheumatoid arthritis are evolving rapidly. We aimed to compare addition of conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) with addition of a tumour necrosis factor antagonist (infliximab) to methotrexate in patients with e...See full text at original site
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引用元:
https://doi.org/10.1016/S0140-6736(09)60944-2

データ提供:米国国立医学図書館(NLM)

Early Rheumatoid Arthritis: Exploring Treatment Strategies

Rheumatoid arthritis (RA) is a chronic autoimmune disease that can cause significant joint pain and inflammation. This study investigates the effectiveness of two different treatment approaches for early RA: adding conventional disease-modifying antirheumatic drugs (sulfasalazine and hydroxychloroquine) to methotrexate, or adding the tumor necrosis factor antagonist infliximab to methotrexate. Researchers carefully enrolled patients with early RA and randomly assigned them to one of the two treatment groups. The researchers closely monitored disease activity and outcomes for one year. The results showed that infliximab, the tumor necrosis factor antagonist, was more effective than the conventional drugs in reducing disease activity and improving outcomes in early RA patients. This research provides valuable insights into the comparative efficacy of different treatment strategies for early RA.

Infliximab: A Potential Game-Changer for Early RA

The study's findings suggest that infliximab could be a more effective treatment option than conventional drugs for patients with early RA. This information can help clinicians choose the most appropriate therapy for individual patients.

Early Intervention: The Key to Managing RA

This research emphasizes the importance of early intervention in managing RA. By starting treatment early and using the most effective therapies, patients can potentially slow the progression of the disease and improve their long-term outcomes. Just as a camel can navigate a desert by anticipating challenges and choosing the best path, early diagnosis and treatment can help individuals manage RA and maintain a good quality of life.

Dr. Camel's Conclusion

Navigating the complexities of rheumatoid arthritis is like traversing a desert landscape. This research provides valuable insights into the effectiveness of different treatment approaches, helping us find the most effective path for patients. By understanding the unique challenges of early RA and embracing innovative treatment strategies, we can empower individuals to manage their condition and live fulfilling lives.

Date :
  1. Date Completed 2009-09-08
  2. Date Revised 2015-11-19
Further Info :

Pubmed ID

19665644

DOI: Digital Object Identifier

10.1016/S0140-6736(09)60944-2

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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