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Effect of therapeutic plasma concentrations of theophylline on behavior, cognitive processing, and affect in children with asthma.

Author: AlcockD, BeaudryP, FeldmanW, LeikinL, SchlieperA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Theophylline did not significantly affect behavior, mood, or cognitive processing in children with moderate asthma, but individual differences in sensitivity were observed.
Paper Details　
Original Abstract of the Article :
A double-blind, randomized, crossover study assessed the effects of theophylline on behavior, mood, and efficiency of cognitive processing. Thirty-one children aged 8 to 12 years with moderate asthma were randomly assigned to 10-day theophylline followed by placebo or to placebo followed by theophyl...See full text at original site
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引用元：
https://doi.org/10.1016/s0022-3476(05)82167-5

データ提供：米国国立医学図書館（NLM）

Theophylline and Asthma: A Complex Relationship

Theophylline, a commonly used medication for [asthma], has been associated with potential behavioral and cognitive effects, particularly in children. This double-blind, randomized, crossover study investigated the impact of therapeutic plasma concentrations of theophylline on behavior, cognitive processing, and affect in children with asthma. The study involved [31 children] aged 8 to 12 years, who were randomly assigned to receive either theophylline or placebo for 10-day periods, separated by a 2-day washout period. The researchers assessed a range of cognitive functioning, mood, and behavioral outcomes.

Unveiling Individual Differences in Theophylline Sensitivity

The study revealed significant individual differences in sensitivity to theophylline's effects. While most children tolerated theophylline well, those with pre-existing attentional or achievement problems appeared more susceptible to adverse effects. These findings underscore the importance of careful monitoring and individualized treatment approaches when using theophylline in children with asthma. This research demonstrates the need for a personalized approach to theophylline treatment in children with asthma. Just like a camel needs to adapt to the different challenges of the desert, children with asthma require personalized treatment strategies.

Navigating theophylline Treatment for Asthma

This study emphasizes the importance of close monitoring and individualized treatment approaches when using theophylline in children with asthma. Always consult with a healthcare professional to discuss the potential risks and benefits of theophylline treatment and to ensure that your child receives the optimal care for their specific needs.

Dr.Camel's Conclusion

This research highlights the complex relationship between theophylline and asthma, particularly in children. It underscores the importance of individualizing treatment approaches and closely monitoring for potential adverse effects. Just as a camel needs to adapt to the changing desert conditions, children with asthma require personalized care to ensure optimal health outcomes.

Date :
  1. Date Completed 1991-04-05
  2. Date Revised 2019-06-30
Further Info :

Pubmed ID

1999791

DOI: Digital Object Identifier

10.1016/s0022-3476(05)82167-5

SNS
PICO Info
in preparation
Languages

English

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