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Comparison of adverse gastrointestinal effects of acarbose and miglitol in healthy men: a crossover study.

Author: AokiKazutaka, ItoYuzuru, MuraokaTomonori, TerauchiYasuo, TogashiYu

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the incidence of gastrointestinal adverse effects with acarbose and miglitol, two alpha-glucosidase inhibitors used for the treatment of type 2 diabetes. The study aimed to address the lack of direct investigation on the adverse effects of these drugs and contribute to understanding their safety profiles.
Paper Details　
Original Abstract of the Article :
The incidence of the gastrointestinal adverse effects is important to determine as these effects are the reason for lower compliance of alpha-glucosidase inhibitors (alphaGIs). There has been no direct investigation of the adverse effects with acarbose or miglitol, therefore we compared them in heal...See full text at original site
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引用元：
https://doi.org/10.2169/internalmedicine.49.3218

データ提供：米国国立医学図書館（NLM）

A Tale of Two Alpha-Glucosidase Inhibitors: Comparing Acarbose and Miglitol

In the world of diabetes management, alpha-glucosidase inhibitors (alphaGIs) play a crucial role by slowing down the breakdown of carbohydrates in the gut. This research compares two prominent alphaGIs: acarbose and miglitol. The researchers aimed to determine the incidence of gastrointestinal adverse effects associated with each drug, as these side effects can significantly impact patient compliance. This study, conducted on healthy subjects, provides valuable insights into the potential differences between these two widely used medications.

A Detailed Look at Gastrointestinal Side Effects

The researchers found that the incidence of gastrointestinal adverse effects varied between the two alphaGIs. This kind of information can help healthcare providers make more informed decisions when choosing the right medication for their patients. While both drugs were generally well-tolerated, the study provides valuable data for weighing the potential benefits and risks of each drug based on individual patient characteristics and preferences.

Understanding the Side Effects of AlphaGIs

This research highlights the importance of being aware of potential side effects, especially gastrointestinal issues, when taking alphaGIs. It's like navigating a desert with two different types of camels, each having its own unique strengths and weaknesses. Healthcare providers and patients need to be aware of these differences and work together to find the best approach for managing diabetes.

Dr.Camel's Conclusion

This study provides valuable insights into the gastrointestinal side effects associated with acarbose and miglitol. It's like discovering a hidden map in the desert of diabetes management! Understanding the potential differences between these two alphaGIs can help healthcare providers make more informed decisions about patient care, ultimately leading to better outcomes.

Date :
  1. Date Completed 2011-03-08
  2. Date Revised 2019-06-06
Further Info :

Pubmed ID

20558922

DOI: Digital Object Identifier

10.2169/internalmedicine.49.3218

Related Literature

Article Analysis
・Effects of miglitol・Effects of acarbose
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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