The effect of perindopril and hydrochlorothiazide alone and in combination on blood pressure and on the renin-angiotensin system in hypertensive subjects.

Author: BackhouseC I, BrownC L, GrippatJ C, SantoniJ P

Paper Details 
Original Abstract of the Article :
The pharmacodynamic effects and acceptability of perindopril (4 mg daily) and hydrochlorothiazide (25 mg daily) given alone or in combination for 1 month were investigated in a double-blind, placebo controlled, parallel group study. The pharmacokinetics of perindopril and its active metabolite perin...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1007/BF00315404

データ提供:米国国立医学図書館(NLM)

Evaluating the Effects of Perindopril and Hydrochlorothiazide on Blood Pressure

This study investigates the effects of two different medications, perindopril and hydrochlorothiazide, on blood pressure in patients with hypertension. It explores the individual and combined effects of these medications on blood pressure levels and the renin-angiotensin system. This research is essential for optimizing blood pressure control in patients with hypertension.

Finding the Right Path to Lower Blood Pressure

The study found that both perindopril and hydrochlorothiazide effectively lowered blood pressure, either alone or in combination. The combined effect was additive for diastolic blood pressure and synergistic for systolic blood pressure. This research provides valuable insights into the different approaches to managing blood pressure in hypertensive patients. It's like finding a variety of paths through the desert, each offering a unique way to reach the oasis of lower blood pressure.

Managing Blood Pressure: A Desert Journey

This research reminds us that there are many ways to navigate the desert of high blood pressure. It's important to work with your doctor to find the best treatment plan for your individual needs. Remember, healthy lifestyle choices, such as exercise and diet, can also contribute to lower blood pressure levels.

Dr.Camel's Conclusion

This study provides a comprehensive evaluation of the effects of perindopril and hydrochlorothiazide on blood pressure, highlighting the importance of individualized treatment approaches for managing hypertension. It's a reminder that even in the vast desert of cardiovascular health, there are always new discoveries and tools to improve our well-being.
Date :
  1. Date Completed 1991-04-23
  2. Date Revised 2019-08-13
Further Info :

Pubmed ID

2076713

DOI: Digital Object Identifier

10.1007/BF00315404

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.