Excellent tolerability but relatively low initial clinical efficacy of telcagepant in migraine.

Author: Tfelt-HansenPeer

Paper Details 
Original Abstract of the Article :
In 3 randomized clinical trials (n = 1585) the calcitonin gene-related peptide antagonist telcagepant 300 mg orally had an incidence of adverse events similar to placebo when used in the acute treatment of migraine. Telcagepant, thus, has excellent tolerability in migraine. Only a quarter (26%) (334...See full text at original site
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引用元:
https://doi.org/10.1111/j.1526-4610.2010.01797.x

データ提供:米国国立医学図書館(NLM)

Telcagepant: A Promising but Incomplete Solution for Migraine

The world of headache medicine is always seeking new solutions to alleviate the debilitating pain and disability caused by migraine. This study, published in [Journal name], investigated the effectiveness of telcagepant, a calcitonin gene-related peptide antagonist, in the acute treatment of migraine. Three randomized clinical trials involving 1585 patients were analyzed.

Telcagepant: Well-Tolerated but Variable Efficacy

While telcagepant was found to be well-tolerated, with an adverse event profile similar to placebo, its efficacy in achieving pain freedom was relatively low. Only 26% of patients achieved pain freedom after 2 hours, compared to 56% who experienced pain relief. While this study suggests that telcagepant holds promise as a migraine treatment, further research is needed to improve its efficacy and identify patients who may benefit most.

Exploring the Desert of Migraine Treatment

Migraine treatment is a journey through a complex and often frustrating desert landscape. This study provides a valuable map, highlighting the potential of telcagepant but also revealing its limitations. Further research is needed to optimize the use of telcagepant and discover new treatments that can offer a more complete solution for those suffering from migraine.

Dr.Camel's Conclusion

The search for effective migraine treatment is like navigating a vast and arid desert, often leaving sufferers feeling lost and parched. This study offers a glimpse of a potential oasis, with telcagepant showing promise but needing further development. Like a camel seeking the most fertile patch of desert, researchers continue their journey in search of the ultimate solution for migraine pain.
Date :
  1. Date Completed 2011-04-25
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

21070229

DOI: Digital Object Identifier

10.1111/j.1526-4610.2010.01797.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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