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The effects of lithium carbonate on healthy volunteers: mood stabilization?

Author: CalilH M, KlepaczS, ZwickerA P

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lithium treatment was associated with decreased mood scores but did not significantly change mood variability. The data suggest that lithium may induce dysphoric mood in some individuals.
Paper Details　
Original Abstract of the Article :
A 2-month lithium-placebo double-blind cross-over study was carried out with 17 healthy volunteers. Their mood was self-rated: twice daily (AM, PM) with the Visual Analogue Mood Scale (VAMS); weekly with the analogue scales for subjective states and body symptoms; and three times (basal and at the e...See full text at original site
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引用元：
https://doi.org/10.1016/0006-3223(90)90586-q

データ提供：米国国立医学図書館（NLM）

The Effects of Lithium Carbonate on Mood in Healthy Volunteers

This research delves into the fascinating world of mood stabilization and explores the effects of lithium carbonate on healthy individuals. The study employed a double-blind crossover design, where 17 volunteers were randomly assigned to receive either lithium or a placebo for a period of two months. Their moods were meticulously assessed using various scales, including the Visual Analogue Mood Scale (VAMS), analogue scales for subjective states and body symptoms, and the Profile of Mood States (POMS). The researchers sought to uncover the impact of lithium on mood stability and variability.

Lithium's Impact on Mood Variability

The researchers discovered that while lithium treatment led to a decrease in average VAMS scores, it did not significantly alter mood variability. However, a trend toward decreased mood variability was observed during the lithium treatment period, particularly in the final week when all volunteers had a lithium serum level ranging from 0.6 to 1.0 mEq/liter. The lower mean VAMS scores observed during lithium treatment could be attributed to lithium-induced dysphoric mood, as documented by the analogue scales and POMS.

Individual Responses to Lithium

A noteworthy observation was the substantial inter- and intraindividual differences in response to lithium. Interestingly, lithium even had an opposite effect on the mood of some volunteers. This highlights the need for a personalized approach to treatment, as individuals react differently to lithium's influence. The researchers emphasized the complexities associated with assessing mood and its fluctuations.

Dr. Camel's Conclusion

This study sheds light on the multifaceted effects of lithium carbonate on mood, emphasizing the importance of individual responses and the need for a personalized approach when considering lithium treatment. It's like a camel caravan traversing a vast desert – each camel navigates the journey in its own unique way. It reminds us that what works for one person may not work for another, especially in the realm of mood regulation.

Date :
  1. Date Completed 1990-05-31
  2. Date Revised 2019-08-15
Further Info :

Pubmed ID

2109639

DOI: Digital Object Identifier

10.1016/0006-3223(90)90586-q

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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