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Meta-analysis of the comparative efficacy and safety of adjuvant treatment to levodopa in later Parkinson's disease.

Author: ClarkeCarl E, DeaneKatherine, FurmstonAlexandra, GrayRichard, HandleyKelly, IvesNatalie, StoweRebecca, WheatleyKeith, van HiltenJ J

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

Levodopa effectively manages Parkinson's disease symptoms initially, but long-term use often leads to movement problems. Other medications, such as dopamine agonists, catechol-O-methyl transferase inhibitors, and monoamine oxidase type B inhibitors, are added to levodopa treatment. This meta-analysis compares the effectiveness and risks of these additional medications in people with Parkinson's disease who have developed movement problems.
Paper Details　
Original Abstract of the Article :
Levodopa initially provides good symptomatic control of the symptoms of Parkinson's disease, but motor complications often develop after long-term use. Other classes of antiparkinsonian drugs including dopamine agonists, catechol-O-methyl transferase inhibitors, or monoamine oxidase type B inhibitor...See full text at original site
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引用元：
https://doi.org/10.1002/mds.23517

データ提供：米国国立医学図書館（NLM）

Navigating Parkinson's Disease: A Meta-analysis of Adjuvant Treatment Strategies

Parkinson's disease, a debilitating neurological disorder, poses a significant challenge for individuals and healthcare providers alike. This research focuses on the effectiveness of adjuvant treatment strategies, exploring the use of various drugs in addition to levodopa, a mainstay treatment for Parkinson's disease. The authors conducted a comprehensive meta-analysis, meticulously evaluating the efficacy and safety of different drug classes used as adjuvant therapy for Parkinson's disease patients experiencing motor complications. Their findings provide valuable insights into the comparative benefits and risks of these adjuvant treatments, offering guidance for healthcare professionals in making informed treatment decisions.

The Quest for Effective Adjuvant Therapy: A Meta-Analysis of Parkinson's Disease Treatments

This meta-analysis provides a comprehensive overview of the evidence surrounding adjuvant treatments for Parkinson's disease. The results highlight the potential benefits and risks associated with different drug classes, offering valuable insights for healthcare professionals. While levodopa remains a cornerstone treatment, this meta-analysis underscores the importance of carefully considering adjuvant therapy options based on individual patient needs and potential risks. This research provides a valuable resource for healthcare professionals, guiding them in making evidence-based decisions about adjuvant therapy for Parkinson's disease.

Living with Parkinson's Disease: Understanding Treatment Options

This research emphasizes the importance of understanding the various treatment options available for Parkinson's disease. The meta-analysis provides a comprehensive overview of the evidence surrounding adjuvant treatments, highlighting both potential benefits and risks. It's crucial to work closely with a healthcare professional to develop a personalized treatment plan that addresses your specific needs and concerns. This research underscores the importance of open communication and collaboration between patients and healthcare providers in managing Parkinson's disease.

Dr.Camel's Conclusion

This research provides a valuable roadmap for healthcare professionals in navigating the complexities of Parkinson's disease. The comprehensive meta-analysis meticulously evaluated the evidence surrounding adjuvant treatment strategies, offering a detailed understanding of the potential benefits and risks associated with various drug classes. This study emphasizes the importance of individualized treatment plans, taking into account patient-specific needs and concerns, to optimize outcomes for individuals living with Parkinson's disease.

Date :
  1. Date Completed 2011-08-15
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

21370258

DOI: Digital Object Identifier

10.1002/mds.23517

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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